Tandem Schiff-Base Formation/Heterocyclization: An Approach to the Synthesis of Fused Pyrazolo–Pyrimidine/Isoxazolo-Pyrimidine Hybrids
Keyword(s):
A new synthesis of pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines is described. Key steps in the synthesis involve Stille coupling of 4,6-dichloro-2-phenyl-pyrimidine with tributyl(1-ethoxyvinyl)stannane and tandem Schiff-base formation/heterocyclization of 2,6-di-aryl-5-fluoro-4-acetylpyrimidine with hydrazines or hydroxylamine to give pyrazolo[4,3-d]pyrimidines and isoxazolo[4,5-d]pyrimidines, respectively. The position of the fluoro group in the pyrimidine ring is important for the success of heterocylization reaction.
2011 ◽
Vol 963
(2-3)
◽
pp. 479-489
◽
2004 ◽
Vol 630
(13-14)
◽
pp. 2558-2561
◽
2004 ◽
Vol 17
(9)
◽
pp. 1206-1216
◽
Keyword(s):
1984 ◽
Vol 20
(4)
◽
pp. 931-934
◽
2015 ◽
Vol 186
◽
pp. 45-50
◽
Keyword(s):
1974 ◽
Vol 12
(10)
◽
pp. 2449-2452
2011 ◽
Vol 19
(15)
◽
pp. 4536-4543
◽