Changes in the Levels of Soluble Adhesion Molecules and Coagulation Factors in Patients with Deep Vein Thrombosis

1999 ◽  
Vol 82 (12) ◽  
pp. 1593-1599 ◽  
Author(s):  
J. W. Quarmby ◽  
M. Collins ◽  
S. M. Lockhart ◽  
K. G. Burnand ◽  
A. Smith
Keyword(s):  
Hip Replacement ◽  
Coagulation Factors ◽  
Activity Assay ◽  
Soluble Adhesion Molecules ◽  
Replacement Surgery ◽  
Vein Thrombosis ◽  
Hip Replacement Surgery ◽  
Adhesive Interactions ◽  
Deep Vein ◽  
Circulating Levels

SummaryCurrent biochemical markers of thrombosis, such as d-dimer, are of little value in demonstrating the presence of thrombus postoperatively, as their levels are elevated by surgery. Thrombosis involves adhesive interactions between the endothelium, platelets and leukocytes. The aim of the study was to determine which of a panel of haemostatic and adhesion factors are altered by the presence of thrombus, but not by surgery. These factors were measured in 20 patients with established spontaneous DVTs, 13 patients having hip replacement surgery and 28 control patients. Circulating levels of P-selectin, VCAM-1 and tissue factor were found to be increased when thrombus was present (p <0.018, p <0.0001, p <0.0028 respectively), but were not altered by surgery. The significance of these circulating factors in venous thrombosis remains to be established, but it is conceivable that they are the product of increased leukocyte trafficking and activity. Assay of VCAM-1, in particular, may be of use in the early detection of venous thrombi in postoperative patients.

Subcutaneous ancrod in prevention of deep vein thrombosis after hip replacement surgery

1982 ◽  
Vol 25 (1-2) ◽  
pp. 23-31 ◽  
Author(s):  
J.J.F. Belch ◽  
D.R. Meek ◽  
G.D.O. Lowe ◽  
A.F. Campbell ◽  
A.B. Young ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Hip Replacement ◽  
Replacement Surgery ◽  
Vein Thrombosis ◽  
Hip Replacement Surgery ◽  
Deep Vein

Perioperative Antithrombinaktivität und Venenthromben nach Hüftersatz

VASA ◽  
2003 ◽  
Vol 32 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Urbach ◽  
Matzen ◽  
Heitmann ◽  
Neumann
Keyword(s):  
Molecular Weight ◽  
Blood Loss ◽  
Hip Replacement ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Activity Levels ◽  
Replacement Surgery ◽  
Vein Thrombosis ◽  
Hip Replacement Surgery ◽  
Deep Vein

Background: The purpose of the study was to evaluate whether the postoperative depletion or the preoperative antithrombin (AT) activity is related to the occurrence of deep vein thrombosis (DVT) in patients receiving low-molecular-weight heparin for DVT prevention after elective hip replacement surgery. Patients and methods: In 93 patients AT-activity and standard laboratory parameter were determined on the preoperative day and daily for one week after operation. Furthermore, a color-coded compression sonography was performed before and 8–10 days after surgery. The amount of blood loss and blood transfusions was evaluated. Patients were divided into two groups in respect to the occurrence of a postoperative DVT. Results: The overall incidence of DVT was 8.6% (n = 8). Patients with DVT had a significantly lower preoperative AT-activity (80.6 ± 3.31%) compared to those without DVT (98.1 ± 1.12%, p < 0.001), how-ever, without being predictive for DVT (positive predictive value 0.71). There was no association between postoperative fall of AT, the lowest postoperative AT activity, blood loss or blood substitution and DVT. Conclusions: It has to be expected that a small fraction of patients for elective hip surgery present with AT-activity levels possibly being insufficient for a therapeutic effect of low-molecular-weight heparin even preoperatively. Those patients are subject to a significant higher risk of DVT postoperatively.

Mechanisms of Hypercoagulability

1999 ◽  
Vol 82 (08) ◽  
pp. 902-906 ◽  
Author(s):  
Ola Dahl
Keyword(s):  
Bone Marrow ◽  
Hip Replacement ◽  
Low Molecular Weight ◽  
Joint Replacement Surgery ◽  
Replacement Surgery ◽  
Vein Thrombosis ◽  
Hip Replacement Surgery ◽  
Heparin Resistance ◽  
Deep Vein ◽  
The Brain

IntroductionPatients undergoing major traumas, major joint replacement surgery, and neurosurgery are at high risk for postoperative deep vein thrombosis (DVT). Even if modern low molecular weight heparin is given as prophylaxis, the frequency of DVT remains high in these patients.1-7 This may indicate that some patients possess a certain “heparin resistance,” due probably due to an overwhelming procoagulant activity and/or because the hypercoagulable state lasts for a longer time than presently assumed. Tissue factor (TF) is the primary cellular initiator of blood coagulation and the most potent trigger of blood clotting known today.8 Adventitia surrounding the major blood vessels, the brain, and the bone marrow are structures with high levels of TF.9 Elective hip replacement surgery, which is a fairly well-standardized procedure that involves a great deal of damage to the bone marrow, is therefore, well-suited as a model to study the mechanisms of hypercoagulability.

scholarly journals Economic Burden of Long-Term Complications of Deep Vein Thrombosis after Total Hip Replacement Surgery in the United States

2003 ◽  
Vol 6 (1) ◽  
pp. 59-74 ◽  
Author(s):  
Joseph A. Caprini ◽  
Marc F. Botteman ◽  
Jennifer M. Stephens ◽  
Vijay Nadipelli ◽  
Mary M. Ewing ◽  
...  
Keyword(s):  
United States ◽  
Deep Vein Thrombosis ◽  
Economic Burden ◽  
Hip Replacement ◽  
The United States ◽  
Replacement Surgery ◽  
Vein Thrombosis ◽  
Hip Replacement Surgery ◽  
Deep Vein
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