Pharmacokinetics and Pharmacodynamics of Lanoteplase (n-PA)
1999 ◽
Vol 82
(S 01)
◽
pp. 121-123
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Keyword(s):
SummaryIn acute myocardial infarction rapid, complete, and sustained reperfusion of the infarct-related coronary artery is the most important therapeutic principle. Lanoteplase or n-PA, a third-generation plasminogen activator consisting of a deletion and point mutant of tissue-type plasminogen activator (t-PA), is a promising agent to appraoch this therapeutic goal. The molecule exhibits an increased plasma half-life allowing single-bolus administration. In this article, after characterizing the n-PA molecule, the currently available pharmacokinetic and pharmacodynamic data including the results of the InTIME study are reviewed.
1998 ◽
Vol 12
(1)
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pp. 45-52
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1990 ◽
Vol 65
(16)
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pp. 1051-1056
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1998 ◽
Vol 19
(1)
◽
pp. 31-38
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1993 ◽
Vol 70
(02)
◽
pp. 294-300
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1996 ◽
Vol 27
(1)
◽
pp. 105-112
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1998 ◽
Vol 32
(3)
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pp. 397-405
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1988 ◽
Vol 60
(02)
◽
pp. 255-261
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1992 ◽
Vol 68
(06)
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pp. 672-677
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