Expression of adhesion molecules on leukocytes of patients with chronic venous insufficiency

SummaryAim: We studied if the expression and release of adhesion molecules is changed in peripheral lymphocytes obtained from patients with chronic venous insufficiency (CVI) of the lower limbs. Methods: 26 patients with CVI (19 primary varicose veins, 7 ulcus cruris) and 39 clinically healthy persons were included in our study. The expression of adhesion molecules on granulocytes, monocytes, and lymphocytes was analysed by flow cytometry. In serum soluble sCD31 and sCD54 was assayed by ELISA, the CD profile was estimated on lymphocytes. Results: In patients suffering from CVI the increased expression of CD11b, CD18, CD54, and CD49d on granulocytes and lymphocytes, of CD62L and CD49d on granulocytes and monocytes, and of CD15 on monocytes and lymphocytes was demonstrated. The highest difference in the expression of adhesion molecules between patients and controls were found on lymphocytes. In patients with CVI lower mean counts of cytotoxic (CD8+) lymphocytes and higher counts of NK cells (CD16+ + CD56+) were seen. The concentration of activated T lymphocytes (CD3 HLA-DR+) and of sCD54 was much higher in the circulation of patients with ulcus cruris than in those with varicose veins or in the controls. Conclusion: Lymphocytes and leukocytes of patients with CVI express elevated concentrations of various adhesion molecules, especially in patients with ulcus cruris. Additionally, significant changes in their CD profile were observed.

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Klippel–Trénaunay Syndrome – A Very Rare and Interesting Syndrome

Clinical Medicine Insights Circulatory Respiratory and Pulmonary Medicine ◽

10.4137/ccrpm.s21645 ◽

2015 ◽

Vol 9 ◽

pp. CCRPM.S21645 ◽

Cited By ~ 11

Author(s):

Deepak Sharma ◽

Sachin Lamba ◽

Aakash Pandita ◽

Sweta Shastri

Keyword(s):

Soft Tissue ◽

Vascular Malformation ◽

Chronic Venous Insufficiency ◽

Venous Insufficiency ◽

Varicose Veins ◽

Lower Limbs ◽

Port Wine ◽

Bone Deformity ◽

Klippel Trenaunay Syndrome

Klippel–Trénaunay syndrome (KTS or KT) is an infrequently seen dermatological syndrome, which is often viewed as a triad of vascular malformation (capillary malformations or port-wine brands), venous varicosity, and soft tissue and/or bony hypertrophy. We report a case of a 12-year-old male who presented to us with the symptoms of varicose plaques over both lower limbs and was diagnosed as a case of KTS. Management is normally conservative and includes stockings for compression of the branches to reduce edema because of chronic venous insufficiency; modern devices that cause on and off pneumatic compression; and rarely, surgical correction of varicose veins with lifelong follow-up. The orthopedic abnormalities are treated with epiphysiodesis in order to prevent (stop) overgrowing of limb and correction of bone deformity.

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LivRelief varicose veins cream in the treatment of chronic venous insufficiency of the lower limbs: A 6-week single arm pilot study

PLoS ONE ◽

10.1371/journal.pone.0208954 ◽

2018 ◽

Vol 13 (12) ◽

pp. e0208954

Author(s):

Heather C. Dwyer ◽

David C. Baranowski ◽

Perry V. Mayer ◽

Simona Gabriele

Keyword(s):

Pilot Study ◽

Chronic Venous Insufficiency ◽

Venous Insufficiency ◽

Varicose Veins ◽

Lower Limbs

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Venous Volumetry In The Assessment Of The Post-Thrombotic Limb

10.1055/s-0038-1652475 ◽

1981 ◽

Author(s):

C V Ruckley ◽

H M Crawshaw ◽

J Seaton

Keyword(s):

Chronic Venous Insufficiency ◽

Venous Insufficiency ◽

Varicose Veins ◽

Response To Treatment ◽

Venous Disease ◽

Clinical Relapse ◽

Non Invasive ◽

Coefficients Of Variation ◽

Primary Varicose Veins

The reproducibility of venous volumetry has been evaluated in 20 normal legs (N), 20 legs with primary varicose veins (W) and 30 with stable post-thrombotic chronic venous insufficiency (CVI).The test has shown significant differences between the groups in mean relative expelled volume (EV rel, ccs): N 1.65 ± SD 0.66; W 1.01 ± 0.40; CVI 0.64 ± 0.39 and in half refilling time (T3 secs): N 23.9 ± 11.5; W 11.8 ± 7.4; CVI 3.6 ± 1.8. The percent coefficients of variation in tests repeated at intervals of up to a month were as follows.The reproducibility of the test confirms its value as a non-invasive means of measuring the severity of postthrombotic venous disease and thus as a means of assessing response to treatment. Serial volumetric tests on 25 patients before and for up to 12 months after Linton operations for chronic venous insufficiency show significant early improvements in expelled volume. But in many of these patients the refilling time tends to remain short indicating residual valvular incompetence and the possibility of clinical relapse in the long term.

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Clinical Profile of Chronic Venous Insufficiency and Varicose Veins of Lower Limbs and Management in North Costal Andhra Region

New Indian Journal of Surgery ◽

10.21088/nijs.0976.4747.10219.16 ◽

2019 ◽

Vol 10 (2) ◽

pp. 225-233

Author(s):

Sarangam Venkata Satya Narayana Rao ◽

◽

Palaka Srinivasa Rao ◽

K. Phani Jotsna ◽

U. Grace Lalitha Priya ◽

...

Keyword(s):

Chronic Venous Insufficiency ◽

Venous Insufficiency ◽

Varicose Veins ◽

Clinical Profile ◽

Lower Limbs

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Chronic Venous Insufficiency in Primary varicose Veins Evaluated by Plethysmographic Technique

Angiology ◽

10.1177/000331979104200606 ◽

1991 ◽

Vol 42 (6) ◽

pp. 468-472 ◽

Cited By ~ 6

Author(s):

Masafumi Hirai ◽

Kenichi Naiki ◽

Ryu Nakayama

Keyword(s):

Chronic Venous Insufficiency ◽

Venous Insufficiency ◽

Varicose Veins ◽

Primary Varicose Veins

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Physical Therapy in Patients with Chronic Venous Insufficiency

Phlebologie ◽

10.1055/s-0037-1617326 ◽

2000 ◽

Vol 29 (02) ◽

pp. 48-53 ◽

Cited By ~ 8

Author(s):

M. Jünger ◽

Anke Steins

Keyword(s):

Physical Therapy ◽

Chronic Venous Insufficiency ◽

Venous Insufficiency ◽

Ulcus Cruris ◽

Chronisch Venöse Insuffizienz ◽

Venöse Insuffizienz ◽

Venöse Stauung ◽

Venöse Drainage

ZusammenfassungWenn Maßnahmen der physikalischen Therapie wie rezeptpflichtige Kompressionsstrümpfe und ein angeleitetes ambulantes Gefäßtraining in einem frühen Stadium begonnen werden, können die Beschwerden des Patienten gelindert, die Gelenkbeweglichkeit und venöse Drainage verbessert und behindernde Stauungserkrankungen wie die Dermatolipofasziitis und das Ulcus cruris vermieden werden. Hat eine chronische venöse Stauung einmal zu einer Atrophie der Gelenkkapsel, Sprunggelenksversteifung und Muskelatrophie des Unterschenkels geführt, sind teure Therapiemaßnahmen einschließlich einer professionellen Krankengymnastik unumgänglich. Unseren eigenen Erfahrungen nach ist eine krankengymnastische Behandlung am wirksamsten, wenn sie in Kombination mit einer biomechanischen Stimulation erfolgt. Sobald der Steppergang des Patienten behoben wurde, können herkömmliche Gehübungen nach und nach das physiologische Gangbild wiederherstellen. Nach erfolgreicher Physiotherapie tragen ein ambulantes Gefäßtraining und eine optimierte Kompressionsbehandlung bei Patienten mit fortgeschrittener chronisch venöser Insuffizienz entscheidend zum langfristigen Therapieerfolg bei. Vergleichbar dem Koronarsport werden Gefäßtrainingsprogramme von den öffentlichen Kassen übernommen. Zusammen mit einer Kompressionsbehandlung stellen sie eine wirksame und kosteneffektive Basistherapie für die chronisch venöse Insuffizienz dar.

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Features of postoperative period in patients with chronic venous insufficiency: phlebectomy versus thermal ablation

Hirurg (Surgeon) ◽

10.33920/med-15-2001-05 ◽

2020 ◽

pp. 64-75

Author(s):

E. Burleva ◽

O. Smirnov ◽

S. Tyurin

Keyword(s):

Postoperative Period ◽

Chronic Venous Insufficiency ◽

Thermal Ablation ◽

Venous Insufficiency ◽

Clinical Symptoms ◽

Varicose Veins ◽

Statistical Processing ◽

Group 3 ◽

Group 2 ◽

Group 1

The purpose of the study was to conduct a comparative assessment of the course of the postoperative period after phlebectomy and thermal ablation in patients with varicose veins of the lower extremities in the system of the great saphenous vein (GSV) with class C2 of chronic venous insufficiency (CVI) — CEAP class C2. Materials and methods: 455 patients (455 limbs) with CEAP class C2. Group 1 (n = 154) received stripping + minimally invasive phlebectomy; Group 2 — endovenous laser ablation (EVLA) of GSV trunk + sclerotherapy of varicose veins; 3 group (n = 150) — radiofrequency ablation (RFA) of the GSV + sclerotherapy. All patients were united by a single tactical solution — the elimination of pathological vertical reflux in GSV. In each group, patients were with similar hemodynamic profile were selected (Group 1 = 63; Group 2 = 61; Group 3 = 61). The course of the postoperative period (from 2 days to 2 months) was compared for pain (visual analog scale — VAS), clinical symptoms of chronic venous insufficiency, degree of satisfaction (Darvall questionnaire), and duration of disability. Statistical processing was carried out using Excel programs for Windows XP, MedCalc® (version 11.4.2.0., Mariakerke, Belgium). Results: Postoperative pain is more pronounced (during day 1 for Group 1–4.0, Group 2–3.0, Group 3–2.0) and more prolonged (up to 4 days) after open surgeries (p < 0.05). The dynamics of the clinical symptoms of CVI (including varicose syndrome and use of compression therapy) could not be fully evaluated in connection with the ongoing sclerotherapy procedures for patients of Groups 2 and 3. Satisfaction of patients with aesthetic aspects was higher than expected in all groups. Reliable statistical differences proved decrease in days of disability (Group 1–14; Group 2–4; Group 3–3) and earlier return to physical activities and work in patients after thermal ablation in comparison with phlebectomy. Conclusion: The study shows that all three methods for eliminating vertical reflux in the GSV can be proposed for a large category of patients with CEAP of class C3 and C2. Medical and social rehabilitation of patients using endovascular thermal ablation technologies proceeds faster, which is beneficial both for the patients and for society.

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