State-of-the-art of small animal imaging with high-resolution SPECT

SummaryDuring the recent years, in vivo imaging of small animals using SPECT has become of growing relevance. Along with the development of dedicated high-resolution small animal SPECT cameras, an increasing number of conventional clinical scanners has been equipped with single or multipinhole collimators. This paper reviews the small animal tomographs, which are operating at present and compares their performance characteristics. Furthermore, we describe the in vivo imaging studies, which have been performed so far with the individual scanners and survey current approaches to optimize molecular imaging with small animal SPECT.

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In vivo imaging neurotransmitter function

Nuklearmedizin ◽

10.3413/nukmed-0371-10-12 ◽

2011 ◽

Vol 50 (04) ◽

pp. 155-156 ◽

Cited By ~ 4

Author(s):

R. Larisch ◽

H. Vosberg ◽

M. Beu ◽

H. Hautzel ◽

A. Wirrwar ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

In Vivo Imaging ◽

Clinical Studies ◽

Small Animal Imaging ◽

Small Animal ◽

Imaging Studies ◽

Animal Imaging

SummaryThis article gives an overview of those small animal imaging studies which have been conducted on neurotransmitter function in the rat 6-hydoxydopamine (6-OHDA) model of Parkinson’s disease, and discusses findings with respect to the outcome of clinical studies on Parkinsonian patients.

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State of the art in vivo imaging techniques for laboratory animals

Laboratory Animals ◽

10.1177/0023677217695852 ◽

2017 ◽

Vol 51 (5) ◽

pp. 465-478 ◽

Cited By ~ 18

Author(s):

David Tibor Lauber ◽

András Fülöp ◽

Tibor Kovács ◽

Krisztián Szigeti ◽

Domokos Máthé ◽

...

Keyword(s):

Computed Tomography ◽

In Vivo Imaging ◽

State Of The Art ◽

Imaging Techniques ◽

Small Animal Imaging ◽

Small Animal ◽

Response To Therapy ◽

Imaging Modalities ◽

Animal Imaging

In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases. The number of animals in a scientific investigation can be substantially reduced using imaging techniques, which is in full compliance with the ethical endeavours for the 3R (reduction, refinement, replacement) policies formulated by Russell and Burch; furthermore, biological variability can be alleviated, as each animal serves as its own control. The most suitable and commonly used imaging modalities for in vivo small-animal imaging are optical imaging (OI), ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and finally the methods of nuclear medicine: positron emission tomography (PET) and single photon emission computed tomography (SPECT).

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