Beurteilung der Adriamycin-Kardiotoxizität mittels der Äquilibrium-Radionuklid-Ventrikulographie

1987 ◽  
Vol 26 (05) ◽  
pp. 206-211 ◽  
Author(s):  
P. Knesewitsch ◽  
N. H. Göldel ◽  
S. Fritsch ◽  
E. Moser
Keyword(s):  
Left Ventricular ◽  
Peak Filling Rate ◽  
Base System ◽  
Filling Rate ◽  
Time To Peak ◽  
Ejection Rate ◽  
Follow Up Studies ◽  
Pathologic Findings ◽  
Peak Ejection Rate

Results of 606 equilibrium radionuclide ventriculographies (ERNV) performed in 348 non-selected patients receiving Adriamycin (ADM) therapy were stored in a data base system. The aim of the study was to assess the influence of a potential cardiotoxic therapy on left ventricular pump function. Increasing ADM doses yielded a significant (p <0.05) decrease of the resting ejection fraction (R-gEF), the peak ejection rate and the peak filling rate. Enddiastolic and endsystolic volumes increased significantly. Stroke volume, heart rate and time to peak filling rate did not change significantly. 368 follow-up studies were performed in 128 patients: 65/128 patients presented a decrease of R-gEF, but only in 45 of these patients R-gEF values fell into the pathologic range. In 44 of these follow-ups, R-gEF remained unchanged. In 19 patients, a R-gEF increase was observed. At the beginning of ADM therapy 14% of the patients had subnormal R-gEF values. With increasing ADM doses pathologic findings increased to 86% in patients with ADM doses higher than 500 mg/m2.

Beurteilung der Adriamycin- Kardiotoxizität mittels der Äquilibrium-Radionuklid- Ventrikulographie

1987 ◽  
Vol 26 (05) ◽  
pp. 212-219
Author(s):  
N. H. Göldel ◽  
S. Fritsch ◽  
E. Moser ◽  
P. Knesewitsch
Keyword(s):  
Early Detection ◽  
Malignant Tumors ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Filling Rate ◽  
Global Ejection Fraction ◽  
Time To Peak ◽  
Ejection Rate ◽  
Peak Ejection Rate ◽  
Higher Sensitivity

The aim of the study was to evaluate the influence of a cardiotoxic therapy with Adriamycin (ADM) on left ventricular pump function. In 348 patients with malignant tumors, 606 equilibrium radionuclide ventriculographies (ERNV) were performed. In 90 patients, resting studies (R-ERNV) were followed by studies during exercise (E-ERNV). Results were evaluated statistically to determine whether E-ERNV provides more reliable parameters in the early detection of Adriamycin cardiomyopathy (ADM-CMP) than R-ERNV. The following left ventricular parameters were evaluated: global ejection fraction (gEF); enddiastolic, endsystolic, stroke volume (EDV, ESV, SV); peak filling rate, peak ejection rate (pFR, pER); time to peak filling rate (TpFR) and heart rate. Increasing ADM doses yielded a significant decrease (p <0.05) of resting values of gEF, pER, pFR. In contrast, stress-induced increases of gEF, pER, pFR were found independent of accumulative ADM doses and independent of the resting values of these parameters. An increase of gEF resulted from a significant decrease of ESV. In most cases, pathologic results at rest were detected earlier than subnormal changes of exercise values. Therefore, E-ERNV does not have a significantly higher sensitivity in the early detection of ADM-CMP than R-ERNV and is not required for the surveillance of patients under ADM therapy.

Echocardiographic assessment of left ventricular function at rest and during exercise in postoperative patients with tetralogy of Fallot

1994 ◽  
Vol 4 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Gunnar Norgård ◽  
Kai Andersen ◽  
Harald Vik-Mo
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Exercise Test ◽  
Healthy Subjects ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Filling Rate ◽  
Ejection Rate ◽  
Peak Ejection Rate ◽  
Fractional Shortening

AbstractDigitized M-mode echocardiograms of left ventricular function were obtained in 34 patients subsequent to surgical repair of tetralogy of Fallot and in 34 healthy subjects at rest. In 16 patients and 16 controls, studies were also made during submaximal semisupine bicycle exercise. At rest, the peak ejection rate and fractional shortening were slightly reduced in the patients, whereas peak filling rate was comparable in patients and controls. Pulmonary regurgitation did not seem to influence left ventricular function. During exercise, however, peak filling rate was reduced in the patients compared to the healthy subjects. At peak exercise, the peak filling rates were 27.8±6.3 cm•s−1 and 34.1±3.4 cm•s−1 in patients and controls, respectively (p<0.01). No differences were found in heart rate, fractional shortening, peak ejection rate or blood pressures between patients and controls throughout the exercise test. When the subjects were subdivided by median age, the oldest patients had reduced normalized peak filling rates throughout the exercise test, whereas no differences were found between younger and older healthy subjects. Thus, it is suggested that the reduced left ventricular peak filling rate found during exercise is caused by subclinical myocardial dysfunction which seems to be related to myocardial protection at surgery and the period of follow-up.

Acute hypothyroidism slows the rate of left ventricular diastolic relaxation

1989 ◽  
Vol 67 (9) ◽  
pp. 1007-1010 ◽  
Author(s):  
Siegfried Wieshammer ◽  
Fritz S. Keck ◽  
Josef Waitzinger ◽  
Eberhard Henze ◽  
Ulrich Loos ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Radionuclide Ventriculography ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Hormone Deficiency ◽  
Filling Rate ◽  
Thyroid State ◽  
Time To Peak ◽  
Volume Curve ◽  
Diastolic Relaxation

The effect of acute thyroid hormone deficiency on left ventricular diastolic filling was studied by radionuclide ventriculography with simultaneous right heart catheterization in nine athyreotic patients without cardiovascular disease. The patients were studied when they were hypothyroid and when they were euthyroid on replacement therapy. Peak filling rate and the time to peak filling were used to characterize diastolic function. The time to peak filling was defined as the interval from end-systole on the radionuclide time–volume curve to the time of occurrence of peak filling. The peak filling rate was determined in absolute terms from the normalized radionuclide peak filling rate and from the end-diastolic volume, which was derived from the radionuclide ejection fraction and from the thermodilution stroke volume. In all patients, the values for peak filling rate were lower in the hypothyroid than in the euthyroid state (287 ± 91 mL/s vs. 400 ± 118 mL/s, Δ = 41 ± 13%, p < 0.01). Peak filling always occurred during the first half of the diastolic interval. The time to peak filling was not significantly affected by the thyroid state (170 ± 10 ms vs. 159 ± 21 ms, Δ = 7 ± 10%). Left ventricular filling pressure as reflected by the pulmonary capillary wedge pressure and end-systolic volume were similar in both thyroid states (6 ± 2 mmHg vs. 8 ± 2 mmHg (1 mmHg = 133.32 Pa) and 32 ± 11 mL vs. 32 ± 7 mL, respectively). The data suggest that the rate of active diastolic relaxation is decreased in short-duration hypothyroidism. This may be due to a depressed activity of the sarcoplasmic reticular calcium pump which is under thyroid control.Key words: hypothyroidism, left ventricular diastolic function, radionuclide ventriculography.

scholarly journals Impact of type 2 diabetes mellitus on left ventricular diastolic function in patients with essential hypertension: evaluation by volume-time curve of cardiac magnetic resonance

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Wei-feng Yan ◽  
Yue Gao ◽  
Yi Zhang ◽  
Ying-kun Guo ◽  
Jin Wang ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Diastolic Function ◽  
Control Group ◽  
Peak Strain ◽  
Filling Rate ◽  
Time Curve ◽  
Time To Peak ◽  
Peak Ejection Rate ◽  
Lv Diastolic Dysfunction

Abstract Background Essential hypertension and type 2 diabetes mellitus (T2DM) are two common chronic diseases that often coexist, and both of these diseases can cause heart damage. However, the additive effects of essential hypertension complicated with T2DM on left ventricle (LV) diastolic function have not been fully illustrated. This study aims to investigate whether T2DM affects the diastolic function of the LV in patients with essential hypertension using the volume-time curve from cardiac magnetic resonance (CMR). Methods A total of 124 essential hypertension patients, including 48 with T2DM [HTN(T2DM +) group] and 76 without T2DM [HTN(T2DM-) group], and 52 normal controls who underwent CMR scans were included in this study. LV volume-time curve parameters, including the peak ejection rate (PER), time to peak ejection rate (PET), peak filling rate (PFR), time to peak filling rate from end-systole (PFT), PER normalized to end-diastolic volume (PER/EDV), and PFR normalized to EDV (PFR/EDV), were measured and compared among the three groups. Multivariate linear regression analyses were performed to determine the effects of T2DM on LV diastolic dysfunction in patients with hypertension. Pearson correlation was used to analyse the correlation between the volume-time curve and myocardial strain parameters. Results PFR and PFR/EDV decreased from the control group, through HTN(T2DM −), to HTN(T2DM +) group. PFT in the HTN(T2DM-) group and HTN(T2DM +) group was significantly longer than that in the control group. The LV remodelling index in the HTN(T2DM −) and HTN(T2DM +) groups was higher than that in the normal control group, but there was no significant difference between the HTN(T2DM −) and HTN(T2DM +) groups. Multiple regression analyses controlling for covariates of systolic blood pressure, age, sex, and heart rate demonstrated that T2DM was independently associated with PFR/EDV (β = 0.252, p < 0.05). The volume-time curve method has good repeatability, and there is a significant correlation between volume-time curve parameters (PER/EDV and PFR/EDV) and myocardial peak strain rate, especially circumferential peak strain rate, which exhibited the highest correlation (r = − 0.756 ~ 0.795). Conclusions T2DM exacerbates LV diastolic dysfunction in patients with essential hypertension. The LV filling model changes reflected by the CMR volume-time curve could provide more information for early clinical intervention.

Left ventricular peak filling rate, heart failure and 1-year survival in patients with acute myocardial infarction

1991 ◽  
Vol 12 (2) ◽  
pp. 194-202 ◽  
Author(s):  
N. GADSBØLL ◽  
P. F. HØILUND-CARLSEN ◽  
J. H. BADSBERG ◽  
H. LØNBORG-JENSEN ◽  
P. STAGE ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Filling Rate

Radionuclide analysis of peak filling rate, filling fraction, and time to peak filling rate

1983 ◽  
Vol 51 (1) ◽  
pp. 43-51 ◽  
Author(s):  
G.B. John Mancini ◽  
Robert A. Slutsky ◽  
Sharon L. Norris ◽  
Valmik Bhargava ◽  
William L. Ashburn ◽  
...  
Keyword(s):  
Peak Filling Rate ◽  
Filling Rate ◽  
Filling Fraction ◽  
Time To Peak ◽  
Radionuclide Analysis

Effects of Left Ventricular Peak Filling Rate on Exercise Capacity 3 to 6 Weeks After Acute Myocardial Infarction

CHEST Journal ◽  
1997 ◽  
Vol 111 (3) ◽  
pp. 590-594 ◽  
Author(s):  
Fumio Yuasa ◽  
Tsutomu Sumimoto ◽  
Toshihiko Hattori ◽  
Toshimitsu Jikuhara ◽  
Makoto Hikosaka ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Exercise Capacity ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Filling Rate

Serial echocardiographic Doppler evaluation of diastolic function in the normal human fetus

1996 ◽  
Vol 6 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Howard S. Weber
Keyword(s):  
Right Ventricular ◽  
Diastolic Function ◽  
Gestational Age ◽  
Fetal Development ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Diastolic Filling ◽  
Filling Rate ◽  
The Right ◽  
Time Velocity Integral

AbstractThe assessment of diastolic function in the developing fetus is difficult because of constantly changing conditions of loading. Previous reports suggesting improved ventricular compliance with fetal development are limited by the Doppler indices utilized. Using load-dependent and independent variables, we examined and compared serially right and left ventricular diastolic function in 11 normal fetuses (44 echocardiographic studies) at 22±1.0 weeks; 30±1.0 weeks; 36±1.0 weeks of gestation and 64±25 hours postnatally. Load-dependent indices included early to late time velocity integral ratios and percentage of early filling to total diastolic filling. The load-independent index was the peak filling rate normalized to the total time velocity integral. Both right and left ventricular time velocity integral ratios were similar initially, and shifted from late to early diastole with increasing gestational age (greater ratios). The shift in left ventricular ratios was greater, and increased earlier in fetal development. The right ventricular normalized peak filling rate decreased with increasing gestational age, while the left ventricular normalized peak filling rate remained constant, but was greater than the right ventricular rate postnatally. Both right and left ventricular filling shifts from late “active” to early “passive” diastole during fetal development. Left ventricular ratios are greater and increase earlier in fetal development, likely influenced by changes in preload. The right and left ventricular normalized peak filling rates were similar prenatally, indicating similar diastolic filling properties, but disparate postnatally, consistent with improved left ventricular relaxation immediately preceding or at the time of onset of transitional circulation.

Importance of adjusting left ventricular diastolic peak filling rate for heart rate

1988 ◽  
Vol 61 (6) ◽  
pp. 489-491 ◽  
Author(s):  
Ragnar Danielsen ◽  
Jan Erik Nordrehaug ◽  
Harald Vik-Mo
Keyword(s):  
Heart Rate ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Filling Rate
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