The Distribution of Radioiodine-Labeled N-Isopropyl-plodoamphetamine in Permanently Ischemic Brain of the Mongolian Gerbil

1988 ◽  
Vol 27 (01) ◽  
pp. 5-7 ◽  
Author(s):  
H. Hoshi ◽  
K. Watanabe ◽  
T. Ueda ◽  
T. Yamaguchi ◽  
S. Jinnouchi

In a study of the distribution of N-isopropyl-p-131l-iodoamphetamine (IMP) in the permanently ischemic brain of 35 mongolian gerbils, the right common carotid artery was ligated under ether anesthesia. After given time intervals, MBq (50μCi) of IMP was injected into 17 gerbils which had severe neurological symptoms, and into 3 normal gerbils for controls. One minute there after each gerbil was sacrified and brain autoradiography was performed. The activity of IMP in various parts of the brain was calculated from each autoradiogram. Low perfusion areas were observed in the right cerebral hemisphere and the brain stem (5-25% of normal value) from the first minute up to 24 h after ligation. In addition, low perfusion areas were also observed in the left cerebral hemisphere (40-60% of normal value) which represented a remote effect. These results suggest the usefulness of IMP for demonstrating cerebral ischemia and diaschisis.

1990 ◽  
Vol 3 (3) ◽  
pp. 143-151 ◽  
Author(s):  
Atsushi Yamadori ◽  
Yukio Osumi ◽  
Masayasu Tabuchi ◽  
Etsuro Mori ◽  
Takashi Yoshida ◽  
...  

We describe a new right hemispheric behavioural syndrome for which we propose the name “hyperlalia”. In a typical case an apparently unconcerned and expressionless patient is easily prompted to remarkable volubility with a content which is loose and incoherent. The voice is low and monotonous. All the lesions confirmed by computed tomography of the brain overlapped in the perisylvian area in the territory of the right middle cerebral artery. Loss of a subtle balance between the left hemispheric speech area and the corresponding area in the right hemisphere caused by acute damage of the right perisylvian area may have resulted in disinhibition of the speech function. Similarities and dissimilarities with the known pathology of talkativeness are also discussed.


1970 ◽  
Vol 30 (3) ◽  
pp. 763-766 ◽  
Author(s):  
Walter F. McKeever ◽  
Maurice D. Huling

Under conditions of monocular unihemispheric projection of word stimuli to the brain, 10 normal Ss uniformly showed superior word recognition ability of the left, as opposed to the right, cerebral hemisphere. Left-hemisphere recognitions were significantly more frequent than right-hemisphere recognitions for both eyes, but the extent of left-hemisphere superiority was significantly greater for the left eye. The results support the hypothesis that words projected to the right hemisphere traverse a less efficient route to the language centers of the left hemisphere.


2000 ◽  
Vol 90 (2) ◽  
pp. 444-450 ◽  
Author(s):  
Jean-Louis Millot ◽  
Gerard Brand

The smelling behavior of 52 right-handed subjects was videotaped during tasks involving identification and recognition of different odors. Analysis showed that men more often used the right nostril than the left whatever the odor. There was no significant difference for the women. These results support a more marked cerebral asymmetry in men than in women and a main involvement of the right cerebral hemisphere in the olfactory processes at least by right-handed men.


2013 ◽  
Vol 7 (2) ◽  
pp. 155-163
Author(s):  
Juliana de Lima Müller ◽  
Jerusa Fumagalli de Salles

ABSTRACT The role of the right cerebral hemisphere (RH) associated with semantic priming effects (SPEs) must be better understood, since the consequences of RH damage on SPE are not yet well established. Objective: The aim of this article was to investigate studies analyzing SPEs in patients affected by stroke in the RH through a systematic review, verifying whether there are deficits in SPEs, and whether performance varies depending on the type of semantic processing evaluated or stimulus in the task. Methods: A search was conducted on the LILACS, PUBMED and PSYCINFO databases. Results: Out of the initial 27 studies identified, 11 remained in the review. Difficulties in SPEs were shown in five studies. Performance does not seem to vary depending on the type of processing, but on the type of stimulus used. Conclusion: This ability should be evaluated in individuals that have suffered a stroke in the RH in order to provide treatments that will contribute to their recovery.


1995 ◽  
Vol 8 (2) ◽  
pp. 121-124
Author(s):  
K. Abe ◽  
R. Yokoyama ◽  
T. Yanagihara

We report a right-handed man who developed selective Kana (phonogram) agraphia following an infarct in the non-dominant right cerebral hemisphere. His ability for comprehension, reading and writing of Kanji (ideogram) was unaffected. Kana errors consisted of substitution with another letter and the number of target words was well preserved. The lesion responsible for his Kana agraphia included the right Wernicke's area (the posterior one-third or one-half of the superior temporal gyrus) on MRI, but he did not have aphasia. Based on these findings, we conclude that the language function in some dextral people may be partially lateralized to the right cerebral hemisphere.


2012 ◽  
Vol 10 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Sumit Thakar ◽  
Yasha T. Chickabasaviah ◽  
Alangar S. Hegde

Invasive craniocerebral aspergillosis, often encountered in an immunocompromised setting, is almost uniformly fatal despite radical surgical and medical management, and is frequently a necropsy finding. The authors report a unique, self-resolving clinical course of this aggressive infection in a 10-month-old infant. The infant was brought to the emergency services in altered sensorium with a 1-week history of left-sided hemiparesis, excessive irritability, and vomiting. An MRI study of the brain revealed multiple, heterogeneously enhancing lesions in the right cerebral hemisphere with mass effect. The largest lesion in the frontotemporal cortical and subcortical regions was decompressed on an emergent basis. Histopathological findings were suggestive of invasive aspergillosis, although there was no evidence of the infection in the lungs or paranasal sinuses. Computed tomography–guided aspiration of the remaining lesions and follow-up antifungal therapy were recommended. The parents, however, requested discharge without further treatment. The child was seen at a follow-up visit 3 years later without having received any antifungal treatment. Imaging showed resolution of the infection and features of Dyke-Davidoff-Masson syndrome (cerebral hemiatrophy). This report of invasive cerebral aspergillosis resolving without medical therapy is the first of its kind. Its clinicoradiological aspects are discussed in light of previously reported cases.


2019 ◽  
Vol 5 (7) ◽  
pp. eaau8301 ◽  
Author(s):  
Jia Hou ◽  
Xu Yang ◽  
Shiyi Li ◽  
Zhekang Cheng ◽  
Yuhua Wang ◽  
...  

Cerebral ischemia (CI) results from inadequate blood flow to the brain. The difficulty of delivering therapeutic molecules to lesions resulting from CI hinders the effective treatment of this disease. The inflammatory response following CI offers a unique opportunity for drug delivery to the ischemic brain and targeted cells because of the recruitment of leukocytes to the stroke core and penumbra. In the present study, neutrophils and monocytes were explored as cell carriers after selectively carrying cRGD liposomes, which effectively transmigrated the blood-brain barrier, infiltrated the cerebral parenchyma, and delivered therapeutic molecules to the injured sites and target cells. Our results showed the successful comigration of liposomes with neutrophils/monocytes and that both monocytes and neutrophils were important for successful delivery. Enhanced protection against ischemic injury was achieved in the CI/reperfusion model. The strategy presented here shows potential in the treatment of CI and other diseases related to inflammation.


2016 ◽  
Vol 10 (2) ◽  
pp. 4-11
Author(s):  
Татьяна Комиссарова ◽  
Tatyana Komissarova ◽  
Елена Гаджиева ◽  
Elena Gadzhieva

The article theoretically and practically substantiates the necessity of teaching Mapping for Bachelors of Tourism. The cartographic competence of future professionals is closely connected with their professional skills. The specific feature of the cartographic method is that it allows one to visualize the geographic space or any simulated space for studying. Consequently it develops the student’s spatial thinking, and makes both cerebral hemispheres be active. It is known that the right cerebral hemisphere is responsible for the creative feature of the human nature, and the left cerebral hemisphere is responsible for the logic. The essence of the cartographic method is that in the process of researching the reality an intermediate element appears. And the intermediate element is a map the role of which is of two kinds: it is a research tool and the subject of research presented as a model, a prototype of the reality at the same time. The symbolic figurative language of a map develops the abstract thinking about the real prototype. It should be emphasized that maps help specialists to establish new patterns in location and interconnection of phenomena. Understanding of the graphic image of the structure of the geographical space, highlighting the peculiarities of the tourist and recreational component, administrating the tourist and recreational space, designing a regional project for the development of tourism, creating package tours – all these professional skills are immediately related to students’ intellectual-graphic activities, to their abilities to visualize the geospace, to be good at Mapping. In the final part of the article the cartographic competence is defined as an element of the culture of a competent specialist in tourism’s personality.


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