Biomarkers of bone metabolism in horses: Ante-mortem versus post-mortem correlation in serum and aqueous humour

2002 ◽  
Vol 15 (02) ◽  
pp. 67-71
Author(s):  
L. T. Glickman ◽  
N. W. Glickman ◽  
E. S. Rasmussen ◽  
S. J. Carlson ◽  
G. J. Breur ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Metabolism ◽  
Aqueous Humour ◽  
Bone Alkaline Phosphatase ◽  
Serum Marker ◽  
Post Mortem ◽  
Potential Marker ◽  
Serum Ictp

SummaryThe objective of this study was to determine the correlation between ante-mortem and 24-hour postmortem concentrations of four markers of bone metabolism in equine serum and aqueous humour. The markers evaluated were osteocalcin, bone alkaline phosphatase, carboxyterminal propeptide of type-1 procollagen and carboxyterminal cross-linked telopeptide of type-1 collagen (ICTP). The concentrations of these markers were poorly correlated (P > 0.05) between aqueous humour and serum. ICTP was the only serum marker significantly correlated (r = 0.93) between ante- and post-mortem samples. ICTP is, therefore, a potential marker for evaluating antemortem markers of bone metabolism in dead horses.

Effects of seasonal vitamin D deficiency and respiratory acidosis on bone metabolism markers in submarine crewmembers during prolonged patrols

2012 ◽  
Vol 112 (4) ◽  
pp. 587-596 ◽  
Author(s):  
Xavier Holy ◽  
Jean-Marc Collombet ◽  
Frédéric Labarthe ◽  
Nicolas Granger-Veyron ◽  
Laurent Bégot
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Bone Metabolism ◽  
Bone Remodeling ◽  
Type I Collagen ◽  
Respiratory Acidosis ◽  
Bone Alkaline Phosphatase ◽  
Type I ◽  
Vitamin D Status ◽  
Seasonal Influence

The aim of the study was to determine the seasonal influence of vitamin D status on bone metabolism in French submariners over a 2-mo patrol. Blood samples were collected as follows: prepatrol and patrol days 20, 41, and 58 on crewmembers from both a winter (WP; n = 20) and a summer patrol (SP; n = 20), respectively. Vitamin D status was evaluated for WP and SP. Moreover, extended parameters for acid-base balance (Pco2, pH, and bicarbonate), bone metabolism (bone alkaline phosphatase and COOH-terminal telopeptide of type I collagen), and mineral homeostasis (parathyroid hormone, ionized calcium and phosphorus) were scrutinized. As expected, SP vitamin D status was higher than WP vitamin D status, regardless of the considered experimental time. A mild chronic respiratory acidosis (CRA) was identified in both SP and WP submariners, up to patrol day 41. Such an occurrence paired up with an altered bone remodeling coupling (decreased bone alkaline phosphatase-to-COOH-terminal telopeptide of type I collagen ratio). At the end of the patrol ( day 58), a partial compensation of CRA episode, combined with a recovered normal bone remodeling coupling, was observed in SP, not, however, in WP submariners. The mild CRA episode displayed over the initial 41-day submersion period was mainly induced by a hypercapnia resulting from the submarine-enriched CO2 level. The correlated impaired bone remodeling may imply a physiological attempt to compensate this acidosis via bone buffering. On patrol day 58, the discrepancy observed in terms of CRA compensation between SP and WP may result from the seasonal influence on vitamin D status.

scholarly journals The Effect of a Moderate Exercise Program on Serum Markers of Bone Metabolism in Dogs

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1481
Author(s):  
Zoran Vrbanac ◽  
Nika Brkljaca Bottegaro ◽  
Branimir Skrlin ◽  
Krunoslav Bojanic ◽  
Vesna Kusec ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Exercise Program ◽  
Bone Alkaline Phosphatase ◽  
Serum Markers ◽  
Treadmill Running ◽  
Moderate Intensity ◽  
Moderate Exercise

The beneficial effect of physical activity on the musculoskeletal health in dogs is well recognized, but the level of intensity, duration, and frequency of exercise is not fully described. Measurement of serum markers of bone metabolism (bone alkaline phosphatase and osteocalcin as bone formation markers and C-terminal telopeptide as bone resorption marker) during four months of organized moderate-intensity physical training in Labrador retriever and Golden retriever dogs aged between 11.7–24.4 months, showed variations of bone metabolism. Dogs were included in treadmill running sessions for 25 min, three times per week. Blood samples were taken at the beginning of the program (baseline), after two months (mid-term) and at the end of the study after four months. The values of bone alkaline phosphatase and osteocalcin significantly decreased following two months of exercise program. Bone alkaline phosphatase increased by the end of four-month training cycle, but did not reach baseline value. Osteocalcin levels continued to decrease towards the end of the study. C-terminal telopeptide concentrations did not significantly change throughout the study duration. The results of this study show that aerobic exercise of moderate-intensity caused an initial decrease in bone formation followed by an increase of bone alkaline phosphatase and a further decrease of osteocalcin concentration. The response of two formation markers can be explained by the different stage of osteoblast activity that they express. In summary, moderate exercise resulted in no change in bone resorption, and a mild bone formation in young developing dogs.

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