Increased Plasma Thrombin-Antithrombin III Complex Levels in Non-Insulin Dependent Diabetic Patients with Albuminuria Are Reduced by Ethyl Icosapentatenoate

SummaryHypercoagulability may increase the risk of cardiovascular disease (CVD) in diabetic patients with albuminuria. Plasma thrombin-antithrombin III complex (TAT) levels, representing a functional state of clotting system, were studied in one hundred and fifteen non-insulin- dependent diabetic (NIDDM) patients. The patients were divided into three groups according to the urine albumin index (UAI: mg/g Cr): Group A; UAI<30, Group B; 30<UAI<300, Group C; UAI>300. The effect of albuminuria on plasma TAT levels was significant (p<0.02). Ethyl icosapentatenoate (EPA: 1800 mg/day) for 4 weeks significantly (p<0.0005) decreased plasma TAT levels. These data indicate that the degree of diabetic albuminuria is related to plasma TAT levels in NIDDM patients and that treatment with EPA may reduce TAT levels and possibly therefore the rate of development of CVD in patients with NIDDM.

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UNDERSTANDING THE ‘SPECIAL NEEDS’ GROUPS FOR SHELTER AND EMERGENCY EVACUATION DURING FLOOD DISASTER

Jurnal Teknologi ◽

10.11113/jt.v78.9484 ◽

2016 ◽

Vol 78 (7-2) ◽

Author(s):

Nur Sabahiah Abdul Sukor ◽

Mohd Ashraf Mohamad Ismail

Keyword(s):

Special Needs ◽

The Elderly ◽

Emergency Evacuation ◽

Flood Disaster ◽

Diabetic Patients ◽

Group A ◽

Insulin Dependent ◽

Evacuation Plan ◽

Group B ◽

Insulin Dependent Diabetic

This paper emphasizes the importance of understanding the diversify of inviduals with special needs for emergency response, relief and aids strategic plan for disaster event. The respondents for this study were the victims of East Coast flood disaster in 2014. The respondents with special needs were divided into two groups; the special needs groups and move to shelter (Group A, N= 340) and the special needs group and not move to shelter (Group B, N=411).The result shows that for Group A the elderly was the highest percentage of the special needs groups. Meanwhile, the insulin dependent diabetic patients dominated the percentages of special needs for Group B. This paper also suggests several methods to establish the data sharing platform between related agencies that focused on the special needs groups to enhance the evacuation plan and process during disaster.

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To study levels of serum fibrinogen in type 2 diabetes mellitus and its association with diabetic microvascular complications

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20170072 ◽

2017 ◽

Vol 4 (1) ◽

pp. 10

Author(s):

Gurinder Mohan ◽

Ranjeet Kaur ◽

Aakash Aggarwal ◽

Parminder Singh

Keyword(s):

Diabetes Mellitus ◽

Microvascular Complications ◽

Vascular Complications ◽

High Serum ◽

Diabetic Patients ◽

Coagulation Disorder ◽

Urine Albumin ◽

Group A ◽

Diabetic Microvascular Complications ◽

Group B

Background: Diabetes mellitus is a hypercoagulable state associated with atherosclerosis leading to development of vascular complications, including microvascular complications.Methods: In our study a total of 60 diabetic patients with duration of diabetes more than 5 years, attending the OPD/ indoor of SGRDIMSR, Amritsar, Punjaqqb, India were included. They were divided in two groups, group A of 30 patients including diabetics with any of the three microvascular complications (diabetic nephropathy, diabetic retinopathy and diabetic neuropathy) and group B of 30 patients including diabetics without any microvascular complication. Group C comprised of 30 age and sex matched non-diabetic subjects who served as controls. Subjects with liver cirrhosis, malignancy or coagulation disorder were excluded. After taking the consent, detailed history taking and detailed physical examination and relevant investigations were done. The serum fibrinogen (hemostasis marker), HBA1C and UACR (urine albumin creatinine ratio) along with routine investigations were measured.Results: It was observed that serum fibrinogen levels were significantly higher in diabetic patients (266.16±54.73 mg/dl) as compared to non-diabetic controls (174.66±18.32 mg/dl); p <0.001.Further, serum fibrinogen levels were found to be significantly higher in diabetic patients with microvascular complications (293.43±51.09 mg/dl) as compared to those without microvascular complications (238.90±44.12); p<0.001.Conclusions: Significantly high serum fibrinogen level was found in diabetic patients as compared to controls and was in positive correlation with development of microvascular complications.

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Thrombin-antithrombin III Complex Level as a Marker of Hypercoagulable State in Insulin-dependent Diabetic Children

Clinical Pediatric Endocrinology ◽

10.1297/cpe.4.1 ◽

1995 ◽

Vol 4 (1) ◽

pp. 1-6

Author(s):

Osamu Nukada ◽

Megumi Kobayashi ◽

Toshikazu Takahashi ◽

Hajime Himei ◽

Tadao Yoda ◽

...

Keyword(s):

Antithrombin Iii ◽

Hypercoagulable State ◽

Diabetic Children ◽

Insulin Dependent ◽

Insulin Dependent Diabetic ◽

Thrombin Antithrombin Iii Complex

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Interactive education and support group: A new approach to permanent education in Type 1 (insulin-dependent) diabetic patients

Patient Education and Counseling ◽

10.1016/0738-3991(94)90155-4 ◽

1994 ◽

Vol 23 ◽

pp. S29

Author(s):

E. Mannucci ◽

G. Colzi ◽

B. Cresci ◽

A. Conti ◽

C.M. Rotella

Keyword(s):

Support Group ◽

Diabetic Patients ◽

New Approach ◽

Interactive Education ◽

Group A ◽

Insulin Dependent ◽

Insulin Dependent Diabetic

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Urinary excretion of transferrin by non-insulin-dependent diabetics: a marker for early complications?

Clinical Chemistry ◽

10.1093/clinchem/35.8.1672 ◽

1989 ◽

Vol 35 (8) ◽

pp. 1672-1674 ◽

Cited By ~ 34

Author(s):

C K Cheung ◽

C S Cockram ◽

V T Yeung ◽

R Swaminathan

Keyword(s):

Arterial Pressure ◽

Urinary Excretion ◽

Healthy Subjects ◽

Healthy Controls ◽

Early Complications ◽

Group A ◽

Insulin Dependent ◽

Group B ◽

Insulin Dependent Diabetic ◽

Sensitive Marker

Abstract We measured concentrations of transferrin (TRF, in micrograms), and creatinine (Cr, in millimoles) in samples of untimed urine from 53 healthy subjects and 157 non-insulin-dependent diabetic (NIDD) subjects. The urinary TRF/Cr ratio was significantly higher in the NIDD group (P less than 0.001). If NIDD subjects are grouped according to their Alb/Cr ratio into normal albuminuria (Group A, Alb/Cr less than 2.5 mg/mmol), microalbuminuria (Group B, Alb/Cr 2.5-26.8 mg/mmol), and macroalbuminuria (Group C, Alb/Cr greater than 26.8 mg/mmol), the TRF/Cr ratios in all three groups exceeded those for healthy controls. Moreover, this ratio was higher in Group B than in Group A and higher in Group C than in Group B. The value for TRF/Cr was clearly abnormal (i.e., exceeded the 95th percentile value found in healthy subjects) in 61%, 95%, and 100% of Group A, B, and C subjects, respectively. The TRF/Cr ratio was significantly higher in those NIDD subjects with clinical retinopathy, and it correlated with arterial pressure. Evidently, TRF/Cr may be increased early in NIDD subjects, and it may be a sensitive marker for detecting development of complications of diabetes.

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Factor II Related Antigen and Antithrombin III Levels as Indicators of Liver Failure in Consumption Coagulopathy

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657171 ◽

1982 ◽

Vol 47 (03) ◽

pp. 218-220 ◽

Cited By ~ 13

Author(s):

P Sié ◽

E Letrenne ◽

C Caranobe ◽

M Genestal ◽

B Cathala ◽

...

Keyword(s):

Liver Failure ◽

Antithrombin Iii ◽

Coagulation Factors ◽

Consumption Coagulopathy ◽

Blood Coagulation Factors ◽

Factor Ii ◽

At Iii ◽

Group A ◽

Group B

SummaryIn order to detect impaired synthesis of blood coagulation factors associated to consumption coagulopathy, a simultaneous evaluation of factor II-related antigen (II rAg) and of antithrombin III (AT III) was carried out in 16 patients affected with severe defibrination. An in vitro preliminary study on plasma and serum demonstrated that the levels of II rAg and of AT III, assessed by the Laurell technique with Behring antisera, were not reduced by the coagulation process. The patients were, a posteriori, classified into two groups according to the absence (group A) or the presence (group B) of factors predisposing to liver failure such as metastasis, cirrhosis, and prolonged shock. II rAg and AT III levels are significantly correlated; they are in the normal range in group A but reduced in group B. Thus II rAg or AT III level determinations are useful markers in the detection of liver failure associated to the consumption phenomenon. These results also suggest that part of the decreased AT III levels reported in severe cases of disseminated intravascular coagulation may be the consequence of an associated liver failure.

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