White Blood Cell Count and Haematocrit as Predictors of Coronary Recurrence after Myocardial Infarction

1985 ◽  
Vol 54 (03) ◽  
pp. 700-703 ◽  
Author(s):  
G D O Lowe ◽  
S G Machado ◽  
W F Krol ◽  
B A Barton ◽  
C D Forbes
Keyword(s):  
Myocardial Infarction ◽  
Relative Risk ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
White Blood Cells ◽  
Total Mortality ◽  
Blood Cell Count ◽  
Coronary Events

SummaryBaseline white blood cell count (WCC) and haematocrit were examined in relation to recurrent coronary events and to all-cause mortality in 2026 persons enrolled in the first Persantin-Aspirin Reinfarction Study (PARIS-1) 2-60 months after myocardial infarction. WCC was strongly related to coronary recurrence (relative risk 3.5 for men with WCC ≥ 9 × 109/1 vs men with WCC < 5 × 109/1) and total mortality (relative risk 2.6). No such relationships were found for haematocrit. WCC correlated also with cigarette-smoking, diuretic use, serum cholesterol and uric acid; however, the associations with coronary recurrence and total mortality persisted on multiple linear and logistic regression analysis including these variables and treatment group (p <0.001). WCC is therefore an easily-measured prognostic variable in survivors of myocardial infarction. Furthermore, we suggest that white blood cells may promote myocardial ischaemia by capillary plugging and/or release of toxic oxygen metabolites.

scholarly journals White Blood Cells and Severe COVID-19: A Mendelian Randomization Study

2021 ◽  
Vol 11 (3) ◽  
pp. 195
Author(s):  
Yitang Sun ◽  
Jingqi Zhou ◽  
Kaixiong Ye
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Blood Cells ◽  
Mendelian Randomization ◽  
Association Studies ◽  
White Blood Cells ◽  
Genome Wide Association Studies ◽  
Blood Cell Count

Increasing evidence shows that white blood cells are associated with the risk of coronavirus disease 2019 (COVID-19), but the direction and causality of this association are not clear. To evaluate the causal associations between various white blood cell traits and the COVID-19 susceptibility and severity, we conducted two-sample bidirectional Mendelian Randomization (MR) analyses with summary statistics from the largest and most recent genome-wide association studies. Our MR results indicated causal protective effects of higher basophil count, basophil percentage of white blood cells, and myeloid white blood cell count on severe COVID-19, with odds ratios (OR) per standard deviation increment of 0.75 (95% CI: 0.60–0.95), 0.70 (95% CI: 0.54–0.92), and 0.85 (95% CI: 0.73–0.98), respectively. Neither COVID-19 severity nor susceptibility was associated with white blood cell traits in our reverse MR results. Genetically predicted high basophil count, basophil percentage of white blood cells, and myeloid white blood cell count are associated with a lower risk of developing severe COVID-19. Individuals with a lower genetic capacity for basophils are likely at risk, while enhancing the production of basophils may be an effective therapeutic strategy.

Impact of prodromal angina pectoris and white blood cell count on outcome of patients with acute myocardial infarction

2005 ◽  
Vol 103 (2) ◽  
pp. 150-155 ◽  
Author(s):  
Masaharu Ishihara ◽  
Ichiro Inoue ◽  
Takuji Kawagoe ◽  
Yuji Shimatani ◽  
Satoshi Kurisu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Angina Pectoris ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Blood Cell Count

scholarly journals White blood cells and severe COVID-19: a Mendelian randomization study

2020 ◽  
Author(s):  
Yitang Sun ◽  
Jingqi Zhou ◽  
Kaixiong Ye
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Blood Cells ◽  
Mendelian Randomization ◽  
White Blood Cells ◽  
Causal Effects ◽  
Blood Cell Count ◽  
Granulocyte Count

AbstractBackgroundThe pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly emerged to seriously threaten public health. We aimed to investigate whether white blood cell traits have potential causal effects on severe COVID-19 using Mendelian randomization (MR).MethodsTo evaluate the causal associations between various white blood cell traits and severe COVID-19, we conducted a two-sample MR analysis with summary statistics from recent large genome-wide association studies.ResultsOur MR results indicated potential causal associations of white blood cell count, myeloid white blood cell count, and granulocyte count with severe COVID-19, with odds ratios (OR) of 0.84 (95% CI: 0.72-0.98), 0.81 (95% CI: 0.70-0.94), and 0.84 (95% CI: 0.71-0.99), respectively. Increasing eosinophil percentage of white blood cells was associated with a higher risk of severe COVID-19 (OR: 1.22, 95% CI: 1.03-1.45).ConclusionsOur results suggest the potential causal effects of lower white blood cell count, lower myeloid white blood cell count, lower granulocyte count, and higher eosinophil percentage of white blood cells on an increased risk of severe COVID-19.

Effect of repeated whole-body x-irradiation on peripheral white blood cell count of rabbits

1959 ◽  
Vol 197 (3) ◽  
pp. 568-570
Author(s):  
Herbert B. Gerstner ◽  
Harry A. Gorman
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
White Blood Cells ◽  
Whole Body ◽  
Blood Cell Count ◽  
Significant Difference ◽  
X Irradiation ◽  
Radiation Induced

Six groups of rabbits received whole-body x-irradiation of 0, 100, 200, 300, 400 and 500 r, respectively. Counts of total white blood cells were performed regularly until 11 weeks post exposure when radiation-induced leucopenia had disappeared in all groups. At that time, the animals were re-exposed to the same doses and white cells were once more counted throughout 11 weeks. Then followed a third application of the same doses with subsequent observation of white counts. Statistical analysis of data yielded the following results: in the three exposures, radiation-induced leucopenia showed no significant difference with respect to rate of development, maximal degree and rate of disappearance. Therefore, as judged by the white blood cell count, susceptibility to ionizing radiation appeared unaltered by previous exposure to appreciable doses when the interval between exposures was sufficiently long to permit complete hematopoietic recovery.

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