Immunoradiometric Assays for Human Coagulation Factor VII Using Polyclonal Antibodies Against the Ca(II)-Dependent and Ca(II)-Independent Conformation

1986 ◽  
Vol 56 (03) ◽  
pp. 343-348 ◽  
Author(s):  
V J J Bom ◽  
N H van Tilburg ◽  
C Krommenhoek-van Es ◽  
R M Bertina
Keyword(s):  
Comparative Study ◽  
Vitamin K ◽  
Polyclonal Antibodies ◽  
Oral Anticoagulants ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Antigen Level ◽  
Healthy Individuals ◽  
Coagulation Factor Vii ◽  
Human Coagulation Factor Vii

SummaryHuman coagulation factor VII is a trace plasma protein belonging to the vitamin K-dependent factors. Two specific and sensitive immunoradiometric assays for factor VII were developed using immunopurified rabbit antibodies against the Ca(II)-independent and Ca(II)-dependent conformation of factor VII. Both assays were insensitive to the activation state of factor VII. The distribution of factor VII antigen was studied in 40 healthy individuals and the antigen level in normal plasma was calculated to be 0.52-0.62 μg/ml. The two assays were used in a comparative study of factor VII procoagulant activity and factor VII antigen in patients treated with oral anticoagulants.

A Polymorphic Cluster in the 5′ Region of the Human Coagulation Factor VII Gene: Detection, Frequency, and Linkage Disequilibrium

1997 ◽  
Vol 88 (5) ◽  
pp. 445-448 ◽  
Author(s):  
Giorgio Dell'Acqua ◽  
Licia Iacoviello ◽  
Andria D'Orazio ◽  
Rosa Di Bitondo ◽  
Augusto Di Castelnuovo ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Gene Detection ◽  
Coagulation Factor Vii ◽  
Detection Frequency ◽  
Human Coagulation Factor Vii

scholarly journals A frequent human coagulation Factor VII mutation (A294V, c152) in loop 140s affects the interaction with activators, tissue factor and substrates

2002 ◽  
Vol 363 (2) ◽  
pp. 411 ◽  
Author(s):  
Raffaella TOSO ◽  
Mirko PINOTTI ◽  
Katherine A. HIGH ◽  
Eleanor S. POLLAK ◽  
Francesco BERNARDI
Keyword(s):  
Tissue Factor ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Coagulation Factor Vii ◽  
Human Coagulation Factor Vii

A missense mutation (178Cys↑Tyr) and two neutral dimorphisms (115His and 333Ser) in the human coagulation factor VII gene

1993 ◽  
Vol 2 (7) ◽  
pp. 1055-1056 ◽  
Author(s):  
G. Marchetti ◽  
M. Ferrati ◽  
P. Patracchini ◽  
R. Redaelli ◽  
F. Bernardi
Keyword(s):  
Missense Mutation ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Coagulation Factor Vii ◽  
Human Coagulation Factor Vii

scholarly journals The first epidermal growth factor domain of human coagulation factor VII is essential for binding with tissue factor

FEBS Letters ◽  
1992 ◽  
Vol 298 (2-3) ◽  
pp. 206-210 ◽  
Author(s):  
Bryan J. Clarke ◽  
Frederick A. Ofosu ◽  
Sampath Sridhara ◽  
Robert D. Bona ◽  
Frederick R. Rickles ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tissue Factor ◽  
Coagulation Factor ◽  
Factor Vii ◽  
Epidermal Growth Factor Domain ◽  
Coagulation Factor Vii ◽  
Epidermal Growth ◽  
Human Coagulation Factor Vii
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