Lead structure optimization of compounds identified to induce differentiation in solid tumors

2018 ◽  
Author(s):  
K Esser ◽  
A Kulik ◽  
A Klinger ◽  
E Fleischer ◽  
H Neubauer ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Structure Optimization ◽  
Lead Structure

scholarly journals Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery

Marine Drugs ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 232 ◽  
Author(s):  
Alexander A. Braddock ◽  
Emmanuel A. Theodorakis
Keyword(s):  
Drug Discovery ◽  
Solid Tumors ◽  
Antimicrobial Properties ◽  
Structure Optimization ◽  
Class Ii ◽  
Clinical Applications ◽  
Complex Structures ◽  
Antibiotic Resistant ◽  
Synthetic Routes

Spirotetronates are actinomyces-derived polyketides that possess complex structures and exhibit potent and unexplored bioactivities. Due to their anticancer and antimicrobial properties, they have potential as drug hits and deserve further study. In particular, abyssomicin C and tetrocarcin A have shown significant promise against antibiotic-resistant S. aureus and tuberculosis, as well as for the treatment of various lymphomas and solid tumors. Improved synthetic routes to these compounds, particularly the class II spirotetronates, are needed to access sufficient quantities for structure optimization and clinical applications.

Recent Studies on a Murine Leukemia Virus Grown in Tissue Culture

1967 ◽  
Vol 25 ◽  
pp. 106-107
Author(s):  
L. Z. de Tkaczevski ◽  
E. de Harven ◽  
C. Friend
Keyword(s):  
Tissue Culture ◽  
Solid Tumors ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Supernatant Fluid ◽  
Virus Particles ◽  
Friend Leukemia ◽  
Type C ◽  
Leukemia Viruses ◽  
Murine Leukemia

Despite extensive studies, the correlation between the morphology and pathogenicity of murine leukemia viruses (MLV) has not yet been clarified. The virus particles found in the plasma of leukemic mice belong to 2 distinct groups, 1 or 2% of them being enveloped A particles and the vast majority being of type C. It is generally believed that these 2 types of particles represent different phases in the development of the same virus. Particles of type A have been thought to be an earlier form of type C particles. One of the tissue culture lines established from Friend leukemia solid tumors has provided the material for the present study. The supernatant fluid of the line designated C-1A contains an almost pure population of A particles as illustrated in Figure 1. The ratio is, therefore, the reverse of what is unvariably observed in the plasma of leukemic mice where C particles predominate.

Infusion of floxuridine in the treatment of solid tumors

JAMA ◽  
1966 ◽  
Vol 197 (4) ◽  
pp. 237-241 ◽  
Author(s):  
R. J. Papac
Keyword(s):  
Solid Tumors
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