Exacerbation outcomes with LAMA/LABA and ICS/LABA in high risk COPD patients in the IMPACT trial

2019 ◽  
Author(s):  
DA Lipson ◽  
F Barnhart ◽  
I Boucot ◽  
C Crim ◽  
N Brealey ◽  
...  
Keyword(s):  
Author(s):  
Madonna Ferrone ◽  
◽  
Marcello G. Masciantonio ◽  
Natalie Malus ◽  
Larry Stitt ◽  
...  

Author(s):  
David A Lipson ◽  
Frank Barnhart ◽  
Isabelle Boucot ◽  
Courtney Crim ◽  
Noushin Brealey ◽  
...  
Keyword(s):  

Author(s):  
David A Lipson ◽  
Frank Barnhart ◽  
Isabelle Boucot ◽  
Courtney Crim ◽  
Noushin Brealey ◽  
...  

BJGP Open ◽  
2020 ◽  
pp. bjgpopen20X101139
Author(s):  
Lonneke Maria Elisabeth Nies ◽  
Looijmans I ◽  
Rozendaal Rozendaal ◽  
Brenda Baar ◽  
Rimke C Vos ◽  
...  

Background: Patients with COPD have an independent increased risk of cardiovascular (CV) disease. CV-risk (CVR) assessment should be offered to all COPD-patients according to the new Dutch ‘CVR management’ (CVRM) guideline (May-2019). Aim: To evaluate the impact of this new guideline for the care of COPD-patients in primary care. Design and Setting: A retrospective study within five primary healthcare centres located in the Netherlands. Methods: In accordance with the guideline we estimated and categorized the CVR of all COPD-patients. Data from 2014–2019 were used for the qualitative risk assessment based on comorbidities, and the quantitative Systematic Coronary Risk Assessment (SCORE). In addition, we investigated the guideline-based follow-up. Results: Of the 391 COPD-patients, 84.1% (n=329) had complete data on CVR assessment: 90.3% (n=297) had a (very)-high risk and 9.7% (n=32) a low-to-moderate risk. Of the patients with (very)-high risk, 73.4% (n=218) received guideline-based follow-up (primary care: 95.4%, secondary care: 4.6%). In 15.9% (n=62) of all COPD-patients, the CVR profile was not measured and of the (very)-high-risk patients, 26.6% (n=79) was not enrolled in a CV-care program. Conclusion: Whereas in the majority of patients the CVR is already known, for one out of six COPD-patients this CVR still has to be assessed according to the recently updated guideline. Moreover, once a (very)-high risk has been assessed, as a consequence CV treatment of risk factors should be intensified in one out of four COPD-patients. Adherence to the new CVRM guideline could provide improvement in CVRM in more than a third of all COPD-patients.


Background: Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and maintain a healthier lifestyle. Eventhough there is mixed evidence of the impact of eHealth on quality of life (QoL) in different settings. Aim: The primary aim of the e-Vita-COPD-study was to investigate the effect of use of eHealth patient platforms on disease specific QoL of COPD patients. Methods: We evaluated the impact of an eHealth platform on disease specific QoL measured with the clinical COPD questionnaire (CCQ), including subscales of symptoms, functional state and mental state. Interrupted time series (ITS) design was used to collect CCQ data at multiple time points. Multilevel linear regression modelling was used to compare trends in CCQ before and after the eHealth intervention. Results: Of 742 invited COPD patients, 244 signed informed consent. For the analyses, we only included patients who actually used the eHealth platform (n = 123). The decrease of CCQ-symptoms was 0,20% before the intervention and 0,27% after the intervention; this difference was statistically significant (P=0.027). The decrease of CCQ-mental was 0,97% before the intervention and after the intervention there was an increase of 0,017%; this difference was statistically significant (P=0,01). No significant difference was found in the slopes of CCQ (P=0,12) and CCQ-function (P=0,11) before and after the intervention. Conclusion: The e-Vita eHealth platform had a potential beneficial impact on the CCQ-symptoms of COPD patients, but not on functional state. The CCQ-mental state remained stable after the intervention, but this was a deterioration compared to the improving situation before the start of the eHealth platform. In conclusion, this study shows that after the introduction of the COPD platform, patients experienced fewer symptoms, but their mental state deteriorated slightly at the same time. Therefore, health care providers should be aware that, although symptoms improve, there might be a slight increase in anxiety and depression after introducing an eHealth intervention to support self-management.


2007 ◽  
Vol 5 (2) ◽  
pp. 77-97 ◽  
Author(s):  
Julian Chow ◽  
Grace Yoo ◽  
Catherine Vu

The passage of the Personal Responsibility and Work Opportunity Act (PRWORA) of 1996 has major implications for low-income Asian American and Pacific Islander (AAPI) populations. The purpose of this paper is to provide an overview of the research currently examining the impact of welfare reform on AAPI recipients and the welfare-to-work services available to this population. This article highlights AAPI participation and their timing-out rates in California’s CalWORKs program and their barriers to transitioning to work. Four welfare-to-work program models and recommendations are presented to illustrate strategies that can be used to address the unique needs of AAPI in order to alleviate their high risk for timing-out: one-stop-shops, transitional jobs programs, providing comprehensive and family focused services, and additional research and evaluation of programs specific to assisting the AAPI population on CalWORKs.


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