Effect of Mini-Dose of Chlorpromazine on the Bleeding time and Platelet Aggregation
The impairment, of hemostasis by ehlorpromazine (c) at concentrations below those which inhibit platelet release reaction, has been evaluated in 24 normal subjects. In each individual, modidied Ivy bleeding time and platelet aggregations (PAg) induced by adenosine diphosphate (ADP) 0,6 MM and 4 MM collagen 0,003% and 1-epinephrine 3MM well as platelet serotonin concentration, were performed prior to and 20 min. after intramuscular administration of (C) or saline. Normal saline was injected to 6 subjects and 5, 12,5 and 20 mg. of (c) to another 8, 5 and 5 subjects respectively. There was a slight but significant prolongation of the bleeding time and a decrease in the initial wave of aggregation to ADP 0,6 MM in the subjects on (C) compared to those on-saline. Platelet serotonin, however, and (PAg) to collagen, 1-epinephrine and ADP 4 MM, were the same in both groups. The impaired hemostasis by mini-dose of (C) might be attributed to the prevention of leakage of ADP from intact erythrocytes in-vivo and, if so, may signify an important new application of this drug in the treatment of thrombotic disorders.