scholarly journals High precision radiotherapy for vulvar cancer in post renal transplantation: Dosimetric challenges

2016 ◽  
Author(s):  
Subhashini John
Keyword(s):  
High Precision ◽  
Planning Target Volume ◽  
Organs At Risk ◽  
Phase 1 ◽  
Target Volume ◽  
Phase 2 ◽  
Plan Evaluation ◽  
Transplanted Kidney ◽  
Precision Radiotherapy ◽  
High Precision Radiotherapy

Background: Patients with renal transplant have a higher incidence of various malignancies. Delivery of adequate radiation dose to the pelvic target in such patients sparing the transplanted kidney is a dosimetric ordeal. Due to lack of sufficient data in the literature regarding the dose constraint of the transplanted pelvic kidney, plan evaluation becomes extremely challenging in this situation. Here we present comparative dosimetric plan evaluation data of treating a patient with carcinoma of the vulva with transplanted kidney. Methods: We compared 3D conformal radiotherapy (3DCRT) and Intensity Modulated Radiotherapy (IMRT) plans for a patient diagnosed to have carcinoma of the vulva with a transplanted kidney. Total dose of radiotherapy (63 Gy) was delivered in two phases (45 Gy in 25 fractions and 18 Gy in 10 fractions respectively). We compared dose to planning target volume (PTV), and dose to organs at risk including the transplanted kidney in these two techniques. The volumes encompassed by different isodoses (50%, 20%, 10%, 5%) were also compared. Weekly renal function test was monitored. Results: The dose received by 95% of the planning target volume in 3DCRT was 43.3 Gy (phase 1), 17.7 Gy (phase 2) and in IMRT was 43.74 Gy (phase 1), 17.3 Gy (phase 2). The mean doses received by kidney in Phase 1 3DCRT, Phase 1 IMRT, phase 2 3DCRT and phase 2 IMRT were 0.98 Gy, 3.05 Gy, 0.74 Gy, 0.13 Gy respectively. The volumes covered by 50%, 20%, 10%, 5% were higher with IMRT plan when compared with 3DCRT plans. The creatinine values remained stable through the treatment. Conclusion: Radiotherapy in renal transplanted patients can be done with high precision radiotherapy techniques with strict dosimetric and image guided set up verification.

scholarly journals High-precision radiotherapy of motor deficits due to metastatic spinal cord compression (PRE-MODE): a multicenter phase 2 study

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Dirk Rades ◽  
Jon Cacicedo ◽  
Antonio J. Conde-Moreno ◽  
Claudia Doemer ◽  
Jürgen Dunst ◽  
...  
Keyword(s):  
Spinal Cord ◽  
High Precision ◽  
Cord Compression ◽  
Motor Deficits ◽  
Phase 2 ◽  
Multicenter Phase ◽  
Phase 2 Study ◽  
Precision Radiotherapy ◽  
High Precision Radiotherapy ◽  
Mode A

scholarly journals Use of a Head-Tilting Baseplate During Tomotherapy to Shorten the Irradiation Time and Protect the Hippocampus and Lens in Hippocampal Sparing-Whole Brain Radiotherapy

2021 ◽  
Vol 20 ◽  
pp. 153303382098682
Author(s):  
Kosei Miura ◽  
Hiromasa Kurosaki ◽  
Nobuko Utsumi ◽  
Hideyuki Sakurai
Keyword(s):  
At Risk ◽  
Planning Target Volume ◽  
Irradiation Time ◽  
Organs At Risk ◽  
Absorbed Dose ◽  
Whole Brain Radiotherapy ◽  
Target Volume ◽  
Whole Brain ◽  
Brain Radiotherapy ◽  
Hippocampal Sparing

Purpose: The aim of this study is to comparatively examine the possibility of reducing the exposure dose to organs at risk, such as the hippocampus and lens, and improving the dose distribution of the planned target volume with and without the use of a head-tilting base plate in hippocampal-sparing whole-brain radiotherapy using tomotherapy. Methods: Five paired images of planned head computed tomography without and with tilt were analyzed. The hippocampus and planning target volume were contoured according to the RTOG 0933 contouring atlas protocol. The hippocampal zone to be avoided was delineated using a 5-mm margin. The prescribed radiation dose was 30 Gy in 10 fractions. The absorbed dose to planning target volume dose, absorbed dose to the organ at risk, and irradiation time were evaluated. The paired t-test was used to analyze the differences between hippocampal-sparing whole-brain radiotherapy with head tilts and without head tilts. Results: Hippocampal-sparing whole-brain radiotherapy with tilt was not superior in planning target volume doses using the homogeneity index than that without tilt; however, it showed better values, and for Dmean and D2%, the values were closer to 30 Gy. Regarding the hippocampus, dose reduction with tilt was significantly greater at Dmax, Dmean, and Dmin, whereas regarding the lens, it was significantly greater at Dmax and Dmin. The irradiation time was also predominantly shorter. Conclusion: In our study, a tilted hippocampal-sparing whole-brain radiotherapy reduced the irradiation time by >10%. Therefore, our study indicated that hippocampal-sparing whole-brain radiotherapy with tomotherapy should be performed with a tilt. The head-tilting technique might be useful during hippocampal-sparing whole-brain radiotherapy. This method could decrease the radiation exposure time, while sparing healthy organs, including the hippocampus and lens.

scholarly journals High-Precision Radiotherapy for Benign Brain Tumors

2014 ◽  
Vol 23 (1) ◽  
pp. 37-42
Author(s):  
Yuta Shibamoto ◽  
Hiroyuki Ogino ◽  
Yoshihiko Manabe ◽  
Gakuo Iwabuchi ◽  
Hiromitsu Iwata ◽  
...  
Keyword(s):  
Brain Tumors ◽  
High Precision ◽  
Precision Radiotherapy ◽  
High Precision Radiotherapy

scholarly journals Patient-Reported Outcome (PRO) as an Addition to Long-Term Results after High-Precision Stereotactic Radiotherapy in Patients with Secreting and Non-Secreting Pituitary Adenomas: A Retrospective Cohort Study up to 17-Years Follow-Up

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1884
Author(s):  
Kerstin A. Kessel ◽  
Christian D. Diehl ◽  
Markus Oechsner ◽  
Bernhard Meyer ◽  
Jens Gempt ◽  
...  
Keyword(s):  
High Precision ◽  
Stereotactic Radiotherapy ◽  
Pituitary Adenomas ◽  
Patient Reported Outcome ◽  
Long Term Results ◽  
Effective Treatment Option ◽  
Patient Reported ◽  
Precision Radiotherapy ◽  
High Precision Radiotherapy

High-precision radiotherapy has been established as a valid and effective treatment option in patients with pituitary adenomas. We report on outcome after fractionated stereotactic radiotherapy (FSRT) in correlation with patient-reported outcomes (PROs). We analyzed 69 patients treated between 2000 and 2019. FSRT was delivered with a median total dose of 54 Gy (single fraction: 1.8 Gy). PRO questionnaires were sent to 28 patients. Median overall survival was 17.2 years; mean local control was 15.6 years (median not reached). Median follow-up was 5.8 years. Twenty (71%) patients participated in the PRO assessment. Physicians reported symptoms grade ≥3 in 6 cases (9%). Of all, 35 (51%) patients suffered from hypopituitarism at baseline, and during follow-up, new or progressive hypopituitarism was observed in 11 cases (16%). Patients reported 10 cases of severe side effects. Most of these symptoms were already graded as CTCAE (Common Terminology Criteria for Adverse Events) grade 2 by a physician in a previous follow-up exam. PROs are an essential measure and only correlate to a certain extent with the physician-reported outcomes. For high-precision radiotherapy of pituitary adenomas, they confirm excellent overall outcomes and low toxicity. In the future, the integration of PROs paired with high-end treatment will further improve outcomes.

Fine-needle Marker for IGRT, a New Fiducial Gold Anchor for High-precision Radiotherapy

2009 ◽  
Vol 75 (3) ◽  
pp. S608-S609 ◽  
Author(s):  
I. Naslund ◽  
P. Wersall ◽  
E. Castellanos ◽  
C. Beskow ◽  
S. Nyrén
Keyword(s):  
High Precision ◽  
Fine Needle ◽  
Precision Radiotherapy ◽  
High Precision Radiotherapy

scholarly journals Risk-adapted single or fractionated stereotactic high-precision radiotherapy in a pooled series of nonfunctioning pituitary adenomas

2014 ◽  
Vol 190 (12) ◽  
pp. 1095-1103 ◽  
Author(s):  
Jan Patrick Boström ◽  
Almuth Meyer ◽  
Bogdan Pintea ◽  
Rüdiger Gerlach ◽  
Gunnar Surber ◽  
...  
Keyword(s):  
High Precision ◽  
Pituitary Adenomas ◽  
Nonfunctioning Pituitary Adenomas ◽  
Precision Radiotherapy ◽  
High Precision Radiotherapy

First experience with a new implantable gold marker for extracranial high precision radiotherapy

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5144-5144
Author(s):  
V. Vinh-Hung ◽  
J. De Mey ◽  
P. De Sutter ◽  
B. Neyns ◽  
Y. Van Nieuwenhove ◽  
...  
Keyword(s):  
High Precision ◽  
Precision Radiotherapy ◽  
Gold Marker ◽  
High Precision Radiotherapy
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