Analgesic and antisympathetic effects of clonidine in burn patients, a randomized, double-blind, placebo-controlled clinical trial

ABSTRACT Objectives:Unlike most other Analgesic drugs, α2 adrenoceptor agonists are capable of producing analgesia. The aim of this study was to evaluate the Analgesic and antisympathetic effects of clonidine, an α2 adrenoceptor agonist in burn patients.Materials and Methods:This randomized, double-blind, placebo-controlled clinical trial performed on one hundred burn patients in Zarea Hospital, Mazandaran, Iran from august 2004 to July 2005. All patients divided in two groups. Case group (n=50) received oral clonidine, 3.3μg/kg TDS and controls (n=50) received placebo. Heart rate and systolic blood pressure and pain severity Visual analogue score (VAS), were recorded after clonidine administration. Statistical analysis was done by means of Mann Witney U test. Results:50 patients (mean age 28.96±10 years) in case group, and 50 patients (mean age 27.60±11.4 years) in control group were studied. VAS pain scores and heart rate in the clonidine group were significantly lower than the control group (P< 0.0001, P< 0.02).there were no significant difference in systolic blood pressure between the two groups on the first and second day but on third day the systolic blood pressure in clonidine group, was lower than controls significantly (P=0.002). Conclusion: This study demonstrates that the use of oral clonidine affects the hemodynamic response to pain in burn patients. Our study demonstrated that clonidine can produce good analgesia and decreased in sympathetic over activity in burn patients, and also reduce opioid dose requirements.

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Blueberries Improve Endothelial Function, but Not Blood Pressure, in Adults with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Nutrients ◽

10.3390/nu7064107 ◽

2015 ◽

Vol 7 (6) ◽

pp. 4107-4123 ◽

Cited By ~ 68

Author(s):

April Stull ◽

Katherine Cash ◽

Catherine Champagne ◽

Alok Gupta ◽

Raymond Boston ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Clinical Trial ◽

Endothelial Function ◽

Controlled Clinical Trial ◽

Double Blind ◽

Double Blind Placebo

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H34 A felodipine-metoprolol combination maintains quality of life and provides better blood pressure control than enalapril: Results from a randomized, double-blind, placebo-controlled clinical trial

American Journal of Hypertension ◽

10.1016/s0895-7061(97)88955-8 ◽

1997 ◽

Vol 10 (4) ◽

pp. 85A

Author(s):

J DETRY

Keyword(s):

Quality Of Life ◽

Blood Pressure ◽

Clinical Trial ◽

Blood Pressure Control ◽

Pressure Control ◽

Controlled Clinical Trial ◽

Double Blind ◽

Double Blind Placebo

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Sumac as a novel adjunctive treatment in hypertension: a randomized, double-blind, placebo-controlled clinical trial

RSC Advances ◽

10.1039/c5ra22840a ◽

2016 ◽

Vol 6 (14) ◽

pp. 11507-11512 ◽

Cited By ~ 12

Author(s):

Hamidreza Ardalani ◽

Maryam Hassanpour Moghadam ◽

Roja Rahimi ◽

Jalal Soltani ◽

Azadeh Mozayanimonfared ◽

...

Keyword(s):

Blood Pressure ◽

Clinical Trial ◽

Adjunctive Treatment ◽

Controlled Clinical Trial ◽

Double Blind ◽

Double Blind Placebo

Sumac; a novel adjunctive treatment in Blood Pressure.

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A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Assessing the Effects of Angelica Gigas Nakai Extract on Blood Triglycerides

Nutrients ◽

10.3390/nu12020377 ◽

2020 ◽

Vol 12 (2) ◽

pp. 377

Author(s):

Su-Jin Jung ◽

Woo-Rim Kim ◽

Mi-Ra Oh ◽

Youn-Soo Cha ◽

Byung-Hyun Park ◽

...

Keyword(s):

Clinical Trial ◽

Placebo Group ◽

Density Lipoprotein ◽

Atherogenic Index ◽

Control Group ◽

Controlled Clinical Trial ◽

Double Blind ◽

Angelica Gigas ◽

Double Blind Placebo ◽

Angelica Gigas Nakai

Angelica gigas Nakai, Korean dang-gui, has long been widely used in traditional treatment methods. There have been a number of studies of the health effects of A. gigas and related compounds, but studies addressing effects on blood triglycerides (TG) are lacking. To investigate the effects of A. gigas Nakai extract (AGNE) on TG in Korean subjects, we carried out a 12-week, randomized, double-blind, placebo-controlled clinical trial. Subjects who met the inclusion criterion (130 mg/dL ≤ fasting blood TG ≤ 200 mg/dL) were recruited for this study. One hundred subjects were assigned to the AGNE group (n = 50) or the placebo group (n = 50), who were given 1 g/day of AGNE (as a gigas Nakai extract 200 mg/d) in capsules and the control group for 12 weeks. Outcomes were efficacy TG, lipid profiles, atherogenic index, and safety parameters were assessed initially for a baseline measurement and after 12 weeks. After 12 weeks of supplementation, TG and very low-density lipoprotein cholesterol (VLDL-C) concentration and TG/HDL-C ratio in the AGNE group were significantly reduced compared to the placebo group (p < 05). No significant changes in any safety parameter were observed. These results suggest that the ingestion of AGNE may improve TG and be useful to manage or prevent hypertriglyceridemia.

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Effects of calcium and vitamin D supplementation on blood pressure and serum lipids and carotenoids: a randomized, double-blind, placebo-controlled, clinical trial

Annals of Epidemiology ◽

10.1016/j.annepidem.2013.07.003 ◽

2013 ◽

Vol 23 (9) ◽

pp. 564-570 ◽

Cited By ~ 28

Author(s):

Weiwen Chai ◽

Robert V. Cooney ◽

Adrian A. Franke ◽

Roberd M. Bostick

Keyword(s):

Blood Pressure ◽

Clinical Trial ◽

Vitamin D ◽

Serum Lipids ◽

Vitamin D Supplementation ◽

Controlled Clinical Trial ◽

Double Blind ◽

Double Blind Placebo

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The Effectiveness of a 5% Retinoic Acid Peel Combined with Microdermabrasion for Facial Photoaging: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Dermatology Research and Practice ◽

10.1155/2017/8516527 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Gita Faghihi ◽

Saghi Fatemi-Tabaei ◽

Bahareh Abtahi-Naeini ◽

Amir Hossein Siadat ◽

Giti Sadeghian ◽

...

Keyword(s):

Clinical Trial ◽

Retinoic Acid ◽

Adverse Effects ◽

Treatment Initiation ◽

Control Group ◽

Controlled Clinical Trial ◽

Double Blind ◽

Double Blind Placebo ◽

Photoaged Skin ◽

The Mean

Background. Tretinoin has been shown to improve photoaged skin. This study was designed to evaluate the efficacy and tolerability of a 5% retinoic acid peel combined with microdermabrasion for facial photoaging. Materials and Methods. Forty-five patients, aged 35–70, affected by moderate-to-severe photodamage were enrolled in this trial. All patients received 3 sessions of full facial microdermabrasion and 3 sessions of either 5% retinoic acid peel or placebo after the microdermabrasion. Efficacy was measured using the Glogau scale. Patients were assessed at 2 weeks and 1, 2, and 6 months after treatment initiation. Results. The mean ± SD age of participants was 49.55±11.61 years, and the majorities (73.3%) were female. Between 1 month and 2 months, participants reported slight but statistically significant improvements for all parameters (P<0.001). In terms of adverse effects, there were statistically significant differences reported between the 5% retinoic acid peel groups and the control group (P<0.001). The majority of adverse effects reported in the study were described as mild and transient. Conclusion. This study demonstrated that 5% retinoic acid peel cream combined with microdermabrasion was safe and effective in the treatment of photoaging in the Iranian population. This trial is registered with IRCT2015121112782N8.

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