Protective effects of ethanol extract of a Mexican propolis on indomethacin-induced gastric mucosal damage in mice.

2019 ◽  
Author(s):  
DV Pilar ◽  
VVS Ibran ◽  
RC Mario ◽  
CA Octavio ◽  
MM Canales-Martinez ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Protective Effects

Nitric oxide and sensory afferent neurones modulate the protective effects of low-dose endotoxin on rat gastric mucosal damage

1995 ◽  
Vol 280 (3) ◽  
pp. 339-342 ◽  
Author(s):  
Ma.Dolores Barrachina ◽  
Sara Calatayud ◽  
Lucrecia Moreno ◽  
Ma.Angeles Martínez-Cuesta ◽  
Brendan J.R. Whittle ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Low Dose ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Protective Effects

Effect of diallyl disulfide on acute gastric mucosal damage induced by alcohol in rats

2014 ◽  
Vol 34 (3) ◽  
pp. 227-239 ◽  
Author(s):  
I-C Lee ◽  
H-S Baek ◽  
S-H Kim ◽  
C Moon ◽  
S-H Park ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
Organosulfur Compound ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Antioxidant Enzyme Activities ◽  
Diallyl Disulfide ◽  
Protective Effects ◽  
Tnf Α

This study investigated the gastroprotective effects of diallyl disulfide (DADS), a secondary organosulfur compound derived from garlic ( Allium sativum L.) on experimental model of ethanol (EtOH)-induced gastric ulcer in rats. The antiulcerogenic activity of DADS was evaluated by gross/histopathological inspection, pro-inflammatory cytokines, and lipid peroxidation with antioxidant enzyme activities in the stomach. DADS (100 mg/kg) was administered by oral gavage 2 h prior to EtOH treatment (5 ml/kg). The animals were killed 1 h after receiving EtOH treatment. Pretreatment with DADS attenuated EtOH-induced gastric mucosal injury, as evidenced by decreased severity of hemorrhagic lesions and gastric ulcer index upon visual inspection. DADS also prevented histopathological alterations and gastric apoptotic changes caused by EtOH. An increase in tumor necrosis factor-α (TNF-α) and inducible nitric oxide synthase was observed in the gastric tissues of EtOH-treated rats that coincided with increased serum TNF-α and interleukin 6 levels. In contrast, DADS effectively suppressed production of pro-inflammatory mediators induced by EtOH. Furthermore, DADS prevented the formation of gastric malondialdehyde and the depletion of reduced glutathione content and restored antioxidant enzyme activities, such as catalase, glutathione peroxidase, and glutathione reductase in the gastric tissues of EtOH-treated rats. These results indicate that DADS prevents gastric mucosal damage induced by acute EtOH administration in rats and that the protective effects of DADS may be due to its potent antioxidant and anti-inflammatory activities.

Protective Effects of Acetaminophen on Ibuprofen-Induced Gastric Mucosal Damage in Rats with Associated Suppression of Matrix Metalloproteinase

2014 ◽  
Vol 349 (1) ◽  
pp. 165-173 ◽  
Author(s):  
Eriko Fukushima ◽  
Noriyuki Monoi ◽  
Shigeo Mikoshiba ◽  
Yutaka Hirayama ◽  
Tetsushi Serizawa ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Protective Effects

Protective Effects of the Whisky Congeners on Ethanol-Induced Gastric Mucosal Damage

2007 ◽  
Vol 31 (3) ◽  
pp. 390-394 ◽  
Author(s):  
Yukinobu Goso ◽  
Masaki Ueno ◽  
Kyoko Hotta ◽  
Kazuhiko Ishihara
Keyword(s):  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Protective Effects

Gastric mucosal protection with chronic mild restraint: role of endogenous prostaglandins

1984 ◽  
Vol 247 (2) ◽  
pp. G127-G132 ◽  
Author(s):  
J. L. Wallace ◽  
M. M. Cohen
Keyword(s):  
Chronic Stress ◽  
Mucosal Injury ◽  
Mucosal Damage ◽  
Gastric Fundus ◽  
Gastric Mucosal Damage ◽  
Gastric Injury ◽  
Protective Effects ◽  
Endogenous Prostaglandins

The role of endogenous prostaglandins (PGs) in adaptation of the rat gastric mucosa to chronic stress was examined. After 10 days of chronic mild restraint (CMR), gastric mucosal damage induced by orally administered 40% ethanol was significantly (P less than 0.01) less extensive than that to control mucosae. When the mucosal injury was produced by oral administration of acetylsalicylic acid (250 mg/kg), there was no protection afforded by prior exposure to CMR. Pretreatment with indomethacin (1 mg/kg ip) abolished the protective effects of CMR against ethanol injury. The indomethacin blockade of CMR protection was reversed by the subsequent administration of PGE2 (75 micrograms/kg po). Fundic samples from 10-day CMR rats synthesized three times as much PGE2 (P less than 0.01) and twice as much 6-keto-PGF1alpha (P less than 0.05) as control samples. Thromboxane B2 synthesis by control and CMR samples was not significantly different. The capacity of gastric fundus and antrum to synthesize PGE2 in vitro was higher in samples from CMR rats than from controls. These results suggest that the resistance to gastric injury that develops during chronic stress is mediated by endogenous prostaglandins.

scholarly journals Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Michael Buenor Adinortey ◽  
Charles Ansah ◽  
Benjamin Aboagye ◽  
Justice Kwabena Sarfo ◽  
Orleans Martey ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Plant Extract ◽  
Mucosal Damage ◽  
Negative Control ◽  
Gastric Mucosal Damage ◽  
Control Group ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Sd Rats ◽  
Whole Plant

Dissotis rotundifolia is a plant in the family Melastomataceae. The methanolic extract of the whole plant is reported to be rich in C-glycosylflavones such as vitexin and orientin. Though there are several reports on the ethnomedicinal use of this plant extract in stomach ulcers, experimental-based data is unavailable. The drive for carrying out this research was to obtain data on the possible ameliorative effect of the whole plant extract of Dissotis rotundifolia (DRE) in gastric ulcerations induced by ethanol in Sprague Dawley (SD) rats. SD rats were pretreated with 100, 300, and 500 mg/kg of DRE for 14 days after which an ulcerogen-ethanol was administered. Gross examinations of the stomach lining and histological analysis of gastric lesions were carried out coupled with an assessment of the antioxidant activity of gastric mucosa using MDA, GSH, CAT, and SOD as indicators. The data suggested a significant attenuation in gastric mucosal damage in DRE-pretreated ethanol-induced gastric ulcer reflected in the antioxidant status. There was also a reduction or absence of hemorrhage, edema, and leucocytes infiltration in DRE-treated groups compared to the negative control group. DRE conserved glutathione (GSH) levels, reduced malondialdehyde (MDA) levels, and enhanced catalase (CAT) and superoxide dismutase (SOD) enzyme levels. The present study shows that DRE possess protective effects against ethanol-induced ulcer damage in the stomach of rats, which could be attributed to its antioxidant activity.

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