The Role of Liver Transplantation for Liver Metastasis from Colorectal Cancer

2020 ◽  
Vol 04 (01) ◽  
pp. 013-018
Author(s):  
Koji Tomiyama ◽  
M. Katherine Dokus ◽  
Jennie Errigo ◽  
Marie Laryea ◽  
Roberto Hernandez-Alejandro
Keyword(s):  
Colorectal Cancer ◽  
Liver Transplantation ◽  
Liver Metastases ◽  
Surgical Resection ◽  
Liver Volume ◽  
Remnant Liver ◽  
Colorectal Cancer Liver Metastases ◽  
Term Survival ◽  
Long Term Survival

AbstractAs chemotherapy for colorectal cancer becomes effective for extending long-term survival, its liver metastases (colorectal cancer liver metastases [CRCLM]) are considered as the progression that best defines patient survival. Surgical resection is the most effective and only curative treatment for CRCLM. Although advancement in liver surgery to increase resectability of CRCLM has borne fruit, there are still limitations, namely tumor burden, remnant liver volume, and chemotherapy-related liver damage. CRCLM used to be considered a contraindication for liver transplantation (LTx) based on preliminary experience in the early era of LTx. Recent advancement in chemotherapy and surgical resection for CRCLM as well as improved outcome of LTx have attracted interest in revisiting this old dogma of LTx for CRCLM. Preliminary experience from Norway has shown promising results and potential for long-term survival with LTx. In this article, we review the history of LTx for CRCLM, rationale for revisiting the concept, early experience from Norway and discuss the issues around and future perspectives on LTx for CRCLM.

T Cell Infiltrate Predicts Long-Term Survival Following Resection of Colorectal Cancer Liver Metastases

2009 ◽  
Vol 16 (9) ◽  
pp. 2524-2530 ◽  
Author(s):  
Steven C. Katz ◽  
Venu Pillarisetty ◽  
Zubin M. Bamboat ◽  
Jinru Shia ◽  
Cyrus Hedvat ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Liver Metastases ◽  
Cell Infiltrate ◽  
Colorectal Cancer Liver Metastases ◽  
Term Survival ◽  
Long Term Survival

New Trends in the Surgical Treatment of Colorectal Cancer Liver Metastases

1998 ◽  
Vol 84 (3) ◽  
pp. 281-288 ◽  
Author(s):  
Steven A. Curley ◽  
Rosario Vecchio
Keyword(s):  
Colorectal Cancer ◽  
Surgical Treatment ◽  
Liver Resection ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Term Survival ◽  
Long Term Survival ◽  
Cancer Metastases ◽  
Colorectal Cancer Metastases

Colorectal cancer is one of the most common solid tumors affecting people around the world. A significant proportion of patients with colorectal cancer will develop or will present with liver metastases. In some of these patients, the liver is the only site of metastatic disease. Thus, surgical treatment approaches are an appropriate and important treatment option in patients with liver-only colorectal cancer metastases. Resection of colorectal cancer liver metastases can produce long-term survival in selected patients, but the efficacy of liver resection as a solitary treatment is limited by two factors. First, a minority of patients with liver metastases have resectable disease. Second, the majority of patients who undergo successful liver resection for colorectal cancer metastases develop recurrent disease in the liver, extrahepatic sites, or both. In this paper, in addition to the results of liver resection for colorectal cancer metastases, we will review the results of cryoablation, heat ablation, and hepatic arterial chemotherapy using a surgically implanted pump. Each of these surgical treatment modalities can produce long-term survival in a subset of patients with liver-only colorectal cancer metastases, whereas systemic chemotherapy used alone rarely results in long-term survival in these patients. While surgical treatments provide the best chance for long-term survival or, in some cases, the best palliation in patients with colorectal cancer liver metastases, it is clear that further improvements in patient outcome will require multimodality therapy regimens.

Surgical microwave ablation of otherwise non-resectable colorectal cancer liver metastases: Expanding opportunities for long term survival

2021 ◽  
Vol 36 ◽  
pp. 61-64
Author(s):  
Kendall R. McEachron ◽  
Jacob S. Ankeny ◽  
Alexandria Robbins ◽  
Ariella M. Altman ◽  
Schelomo Marmor ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Microwave Ablation ◽  
Colorectal Cancer Liver Metastases ◽  
Term Survival ◽  
Long Term Survival

scholarly journals O-0030 Long Term Survival Data from EORTC Study 40983: Perioperative Chemotherapy for Resectable Liver Metastases from Colorectal Cancer

2012 ◽  
Vol 23 ◽  
pp. iv18
Author(s):  
Bernard Nordlinger ◽  
Halfdan Sorbye ◽  
Bengt Glimelius ◽  
Graeme John Poston ◽  
Peter M. Schlag ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Survival Data ◽  
Perioperative Chemotherapy ◽  
Term Survival ◽  
Long Term Survival

scholarly journals A Case of Two Resections for Metachronous Liver Metastases of Gastric Cancer: A Case Report and Review of the Literature

2018 ◽  
Vol 1 (1) ◽  
pp. 01-06
Author(s):  
Ishibashi Yusuke ◽  
Tsujimoto Hironori ◽  
Yamamoto Junji ◽  
Ueno Hideki
Keyword(s):  
Gastric Cancer ◽  
Liver Metastases ◽  
Surgical Resection ◽  
Vena Cava ◽  
Term Survival ◽  
Case Presentation ◽  
Long Term Survival ◽  
Solitary Metastases ◽  
Selection Of

Background: The clinical significance of surgical resection for liver metastases of gastric cancer remains controversial. Herein, we report a case of twice resections for metachronous liver metastases of gastric cancer in combination with perioperative chemotherapy, which resulted in long-term survival. Case Presentation: The patient was a 66-year-old man who underwent laparoscopic total gastrectomy for gastric cancer (Stage IB) in March 2012, and subsequently underwent right hemi-hepatectomy with partial resection of the vena cava and diaphragm for solitary metastases in segments 7-8 in April 2013. In September 2013, abdominal computed tomography detected a liver metastasis in segment 4. We administered systematic chemotherapy with S-1 plus cis-diamminedichloroplatinum (CDDP). Because the tumor decreased in size after five courses, and curative resection of the tumor was considered possible, hepatic resection of S4+1 was performed in June 2014. The patient has been followed for 26 months, and, after the last hepatectomy, had no evidence of recurrence.Conclusion: We experienced a case of long-term survival after twice resections for liver metastases from gastric cancer. Surgical resection for liver metastases of gastric cancer, even repeat hepatectomy, may be an effective treatment after careful selection of the optimal candidate.

Liver Transplantation for Cholangiocarcinoma

2012 ◽  
Vol 08 (03) ◽  
pp. 173
Author(s):  
Armin Thelen ◽  
Christoph Benckert ◽  
Sven Jonas ◽  
◽  
◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Long Term Results ◽  
Treatment Modalities ◽  
Neoadjuvant Radiochemotherapy ◽  
Organ Shortage ◽  
Remnant Liver ◽  
Term Survival ◽  
Treatment Protocols ◽  
Long Term Survival

The treatment of intra- and extrahepatic cholangiocarcinomas remains a medical challenge. Due to the poor efficacy of conventional chemotherapy, surgical treatment modalities represent the only chance of attaining long-term survival and cure. The introduction of new procedures, in particular extended liver resections – which were enabled by increasing surgical expertise and the implementation of multimodal treatment protocols – led to an increasing number of curatively treated patients and significant improvements in long-term results after curative resection. However, numerous patients are not suitable for radical resection because of local tumour growth, intrahepatic metastases, infiltration of main vascular and biliary structures or insufficient remnant liver function. In unresectable tumours, liver transplantation is a curative treatment option for many patients and represents the only chance to achieve long-term survival and cure. Yet, cholangiocarcinomas are not currently a standard indication for liver transplantation, because of the organ shortage and the resulting necessity to allocate available organs to patients with the best prognosis. In recent years, the results of liver transplantation for the different types of cholangiocarcinoma have improved following the application of new treatment protocols. The most promising long-term results were achieved in hilar cholangiocarcinoma by using neoadjuvant radiochemotherapy prior to transplantation. Long-term survival rates were not inferior to those seen in patients receiving a transplantation for benign liver diseases or early-stage hepatocellular carcinoma. The improved long-term outcomes of transplantation for intra- and extrahepatic cholangiocarcinomas have led to a renewed interest for liver transplantation as a treatment for these tumour entities.

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