Michael Addition of Indoles to Enones Catalyzed by a Cationic Iron Salt
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AbstractIndoles are one of the most valuable nucleophiles in Michael additions catalyzed by a proper Lewis acid. In this paper, we found that a cationic iron salt is effective to carry out the Michael addition of indoles. β-Mono- and disubstituted enones reacted smoothly with indoles under our conditions. The cationic iron catalyst is very active, and the maximum TON was up to 425. Moreover, cationic iron-catalyzed conditions enabled a chemoselective Michael addition of a substrate possessing both enone and α,β-unsaturated ester moieties.
1986 ◽
Vol 51
(2)
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pp. 279-280
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2016 ◽
Vol 81
(8)
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pp. 871-881
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2017 ◽
Vol 41
(3)
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pp. 168-171
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