scholarly journals Evidence and Considerations on Treatment of Small Size Merkel Cell Head and Neck Carcinoma

2020 ◽  
Vol 24 (04) ◽  
pp. e487-e491
Author(s):  
Elena Festa Kotelnikova ◽  
Melissa Laus ◽  
Adelchi Croce
Keyword(s):  
Parotid Gland ◽  
Head And Neck ◽  
Neck Dissection ◽  
Clinical Information ◽  
Head And Neck Carcinoma ◽  
Lower Eyelid ◽  
Lymph Node Biopsy ◽  
Merkel Cell ◽  
Positron Emission ◽  
Excision Margins

Abstract Introduction Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine malignant cancer. It is an epidermal cancer common in the head and neck. Objectives Though there is limited number of cases described in the literature for the treatment difficult to obtain. Our purpose was to present the clinical course and treatment of four patients with MCC. Methods We conducted a retrospective analysis and obtained detailed clinical information for all 4 patients treated for MCC at the ENT Department of the SS Annunziata Hospital in Chieti, Italy, from 2013 through 2015. Results In our study, two patients presented with the tumor in a rare site (lower eyelid). All of the patients underwent surgical treatment: three patients had free excision margins and negative sentinel lymph nodes (SLNs) while 1 patient had free excision margins and positive SLNs. The latter patient underwent ipsilateral neck dissection. In another patient, the fluorodeoxyglucose positron emission topography (FDG PET)/computed tomography (CT) performed 6 months after the surgery has shown high metabolic activity in the left parotid gland, and the patient underwent total parotidectomy and a neck dissection. Conclusion Sentinel lymph node biopsy is a useful technique in small size MCCs of the head and neck. However, the parotid gland should be strictly controlled in patients with lower eyelid tumors.

The potential role of imaging techniques in avoiding neck dissection during salvage surgery after head and neck carcinoma treated with bioradiotherapy

2021 ◽  
Vol 135 (11) ◽  
pp. 970-975
Author(s):  
A Rovira ◽  
J Tornero ◽  
M Taberna ◽  
M Oliva ◽  
R Montal ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Head And Neck ◽  
Neck Dissection ◽  
Salvage Surgery ◽  
Head And Neck Carcinoma ◽  
Emission Tomography ◽  
Positron Emission ◽  
Neck Carcinoma

AbstractObjectiveThis study aimed to evaluate the effectiveness of computed tomography and positron emission tomography-computed tomography prior to salvage surgery after head and neck carcinoma treated with bioradiotherapy and to look at the role of neck dissection in this setting.MethodThis study was a retrospective chart review of a series of consecutive patients with locally advanced head and neck squamous cell carcinoma treated with bioradiotherapy. Radiological and pathological stages were compared to evaluate the accuracy of computed tomography and positron emission tomography-computed tomography in detecting occult neck metastasis in the context of recurrence of primary tumour. In order to assess the impact of neck dissection on survival, Kaplan–Meier survival curves after salvage surgery with and without neck dissection were derived.ResultsA total of 268 patients were identified, of which 22 underwent salvage surgery. The negative predictive value of computed tomography and positron emission tomography-computed tomography was excellent. Neck dissection did not represent an improvement on overall, disease specific and regional recurrence free survival (p = 0.67, p = 0.91 and p = 0.62, respectively) amongst clinically and radiologically negative necks.ConclusionConservative treatment of the neck should be considered when dealing with patients with primary site recurrence or persistent disease after bioradiotherapy without evidence of neck disease.

scholarly journals Parotid gland metastasis in Merkel cell carcinoma of the head and neck: A series of 14 cases

2016 ◽  
Vol 95 (9) ◽  
pp. 398-403 ◽  
Author(s):  
Kristine E. Day ◽  
William R. Carroll ◽  
Eben L. Rosenthal
Keyword(s):  
Lymph Node ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Merkel Cell Carcinoma ◽  
Unknown Primary ◽  
Mortality Data ◽  
Merkel Cell

Merkel cell carcinoma (MCC) is a rare cutaneous cancer of neuroendocrine cell origin that occurs frequently on the head and neck. With a high incidence of local recurrence and regional and distant metastasis, it carries a poor prognosis. We performed a retrospective study to determine the prognostic implications of parotid gland metastasis in MCC of the head and neck. Our study population was made up of 14 patients—13 men and 1 woman, aged 62 to 87 years (mean: 75.9)—who underwent a parotidectomy for the diagnosis of MCC over a period of 10 years and 9 months. Ten patients had a primary skin lesion of the head and neck and 4 presented with a parotid mass and an unknown primary. In all, 13 of the 14 patients were found to have parotid involvement—either a direct extension of MCC into the gland or a positive intraparotid lymph node; some patients had both. All patients underwent tumor excision, and 10 underwent neck dissection. Eleven patients received adjuvant radiotherapy; none received adjuvant chemotherapy. Of the 10 patients who underwent a neck dissection, 6 were found to have a cervical lymph node metastasis on pathologic examination. Follow-up ranged from 1.3 to 39.2 months (mean: 12.4). Three patients were lost to follow-up shortly after surgery, although some information was available on 2 of them. At the final follow-up, mortality data were available on 12 patients; of these, 11 had died. The lone survivor was the patient without a parotid metastasis. Among those known to have died, survival ranged from 1.6 to 49.2 months (mean: 16.0). We conclude that parotid metastasis in patients with MCC of the head and neck is associated with a dismal survival rate that is even worse than the poor survival associated with cervical node involvement.

scholarly journals Reliability of Sentinel Lymph Node Biopsy for Regional Staging of Head and Neck Merkel Cell Carcinoma

2005 ◽  
Vol 131 (7) ◽  
pp. 610 ◽  
Author(s):  
Cecelia E. Schmalbach ◽  
Lori Lowe ◽  
Theodoros N. Teknos ◽  
Timothy M. Johnson ◽  
Carol R. Bradford
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Merkel Cell Carcinoma ◽  
Lymph Node Biopsy ◽  
Merkel Cell ◽  
Node Biopsy

Role of neck dissection in metastatic squamous cell carcinoma to the parotid gland

2016 ◽  
Vol 130 (S4) ◽  
pp. S54-S59 ◽  
Author(s):  
S W Park ◽  
T Eade ◽  
L Pang ◽  
A Wignall ◽  
D Veivers
Keyword(s):  
Squamous Cell Carcinoma ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Consecutive Series ◽  
Radiological Evidence ◽  
Neck Disease ◽  
Positron Emission ◽  
Metastatic Squamous Cell Carcinoma

AbstractObjective:To investigate the rate of occult neck disease in patients with metastatic squamous cell carcinoma to the parotid gland following parotidectomy and neck dissection.Methods:A consecutive series of patients treated between 2000 and 2014 for metastatic squamous cell carcinoma to the parotid were analysed. Patients were included if they had no clinical or radiological evidence of neck disease. Pathology of parotidectomy and neck dissection specimens was reviewed. Other variables analysed included patient immune status, surgery type, complications, use of positron emission tomography scanning and treatment with radiotherapy.Results:Sixty-five patients had no clinical or radiological evidence of neck disease initially. Forty-six patients (70.8 per cent) underwent neck dissection. Occult neck disease was only found in 8 of the 46 patients (17.3 per cent). Occult neck disease was found more often in those with immunocompromise (5.7 vs 38.5 per cent, p = 0.003). Patients who were immunocompromised had a significantly worse disease-specific survival rate at five years (0 vs 92 per cent, p = 0.0001).Conclusion:Occult neck disease was seen in 17.3 per cent of patients and immunosuppression was a significant predictor for this.

Surgical management of lymphangiomas in adults

1996 ◽  
Vol 110 (6) ◽  
pp. 586-589 ◽  
Author(s):  
A. J. Curran ◽  
N. Malik ◽  
D. McShane ◽  
C. V. I. Timon
Keyword(s):  
Parotid Gland ◽  
Facial Nerve ◽  
Head And Neck ◽  
Neck Dissection ◽  
Surgical Management ◽  
Neck Region ◽  
Selective Neck Dissection ◽  
Older Population ◽  
Head And Neck Region ◽  
Congenital Tumours

AbstractLymphangiomas are uncommon benign congenital tumours. Most occur in the head and neck region and the vast majority present before the age of two. This paper describes the presentation and management of four cases presenting after puberty and involving the parotid gland. The cases are unusual in that all were intimately associated with the facial nerve and in an older population. The value of selective neck dissection and facial nerve exposure as an approach to these lesions is discussed.

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