Peptic Ulcer Disease in Patients Under Antiplatelets or Anticoagulants: Analysis of Upper Gastrointestinal Endoscopy Findings

2021 ◽  
Author(s):  
I Mitselos ◽  
M Moutzoukis ◽  
C Lamouri ◽  
N Tsoumani ◽  
A Petrou ◽  
...  
2012 ◽  
Vol 13 (4) ◽  
pp. 180-183
Author(s):  
Ali Kagan Gokakin ◽  
Atilla Kurt ◽  
Gunduz Akgol ◽  
Boran Cihat Karakus ◽  
Mustafa Atabey ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Onyedika Godfrey Okoye ◽  
Oluwole Olayemi Olaomi ◽  
Alexander M.E. Nwofor ◽  
Paul Jibrin ◽  
Cephas Shallangwa Batta ◽  
...  

Background. Peptic ulcer disease (PUD) remains one of the most prevalent gastrointestinal diseases and has been linked to Helicobacter pylori (H. pylori) infection. This condition may be suspected on clinical grounds, but diagnosis is established using upper gastrointestinal endoscopy. Aims. To determine the correlation between the endoscopic and pathological findings among suspected PUD patients who have been referred for diagnostic upper gastrointestinal endoscopy in National Hospital Abuja. Methods. This is a hospital-based prospective study conducted among suspected PUD patients at National Hospital Abuja over a one-year period. Clinical, endoscopic, and histological findings were ascertained and documented. Data obtained were analyzed using SPSS version 21.0. Tests of significance were done using the chi-square test and Student t -test at 95% confidence intervals. Results. One hundred and thirty-two patients were included in the study. The ages ranged from 15 to 87 years, mean age 43.30 ± 11.94 years. Seventy-seven (58.3%) patients had abnormal endoscopic findings, of whom 37 (28.0%) had PUD. Prevalence of H. pylori infection was 42.2% and was found in 81.1% of PUD patients. H. pylori was significantly associated with confirmed PUD ( p < 0.001 ) and abnormal endoscopic findings ( p < 0.001 ). No association was found between normal endoscopic findings and histological findings ( p = 0.924 ). Conclusion. There is a poor correlation between clinical and endoscopic diagnoses of PUD. H. pylori was found to be significantly associated with PUD and abnormal endoscopic findings. Endoscopic facilities should therefore be made available and accessible for proper PUD diagnosis. Empirical treatment of H. pylori in patients with diagnosed PUD is strongly recommended.


2021 ◽  
Author(s):  
Belete Assefa ◽  
Abilo Tadesse ◽  
Zinahebizu Abay ◽  
Alula Abebe ◽  
Tsebaot Tesfaye ◽  
...  

Abstract Background: Dyspepsia is a common complaint in upper gastrointestinal disorders. It is described as predominant epigastric pain lasting for at least one month. Peptic Ulcer Disease (PUD) occurs in 5-15% of patients with dyspepsia. Helicobacter pylori (H.pylori) infection and non-steroidal anti-inflammatory drugs (NSAIDs)/aspirin (ASA) use are widely known risk factors for PUD. This research article aimed to determine the prevalence of PUD and associated factors among dyspeptic patients at the endoscopy unit, University of Gondar hospital, Northwest Ethiopia.Methods: A hospital-based cross-sectional study was conducted at University of Gondar hospital. A sample of 218 adults who presented with the complaint of dyspepsia, and underwent endoscopic evaluation were interviewed from June 1 to November 30, 2020. A consecutive sampling method was used to recruit the study subjects. Relevant clinical history was obtained from patients’ medical records. Upper gastrointestinal endoscopy was used to confirm the presence of peptic ulcer disease. The Data were entered into EpiData version 4.6.0.2 and exported to SPSS version 20 for analysis. Logistic regression analysis was used to identify associated factors with the occurrence of PUD among dyspeptic patients. P-value <0.05 was used to declare a statistically significant association.Results: A total of 218 dyspeptic patients who underwent upper gastrointestinal endoscopic evaluations were included in the study. The PUD was diagnosed in one-third of patients with dyspepsia. Dyspeptic patients with active H. pylori infection (AOR=6.3, 95%CI: 2.96-13.38) and NSAIDs/ASA use (AOR=6.2, 95%CI: 2.93-13.36) were at higher risk of developing PUD.Conclusion: The magnitude of active H. pylori infection among symptomatic PUD patients was high. So then, a “test-and-treat” strategy is advised. Cautious use of NSAIDs/ASA is required as it is readily available over-the-counter.


2021 ◽  
Vol 14 (7) ◽  
pp. e242055
Author(s):  
Raja Samir Khan ◽  
Sardar Momin Shah-Khan ◽  
Justin Kupec

Over-the-counter analgesic medications are widely used amongst American adults and are also available in powder forms. Their adverse effects have been well documented in literature. Gastrocolic fistulas as a complication of peptic ulcer disease from analgesic powder usage have been previously unreported. Here, we report a patient with upper gastrointestinal bleeding and acute anaemia secondary to peptic ulcer complicated by gastrocolic fistula in a patient using analgesic powder.


2015 ◽  
Vol 22 (07) ◽  
pp. 871-875
Author(s):  
Salman Khan ◽  
Tahir Ghaffar ◽  
Ismatullah Khan

The most common single cause of anemia worldwide is Iron deficiency. It resultsfrom other underlying diseases and to look for its cause is very crucial and is of far greaterimportance than restoring the iron stores and hemoglobin levels. Objectives: To determine thefrequency of common upper gastrointestinal endoscopic findings in elderly patients with irondeficiency anemia presenting with dyspepsia. Study Design: Cross sectional descriptive study.Setting: Department of Medicine, Khyber Teaching hospital, Peshawar. Period: March, 2011 toSeptember, 2011. Materials and Methods: 116 patients, all the patients with iron deficiencyanemia presenting with dyspepsia were subjected to upper gastrointestinal endoscopy todetect common findings as gastric erosions, peptic ulcer and gastric carcinoma. StatisticalAnalysis: Data was analyzed with SPSS 10.0. Results: On upper gastrointestinal endoscopy,normal findings were noted 30 (25.86%) patients and abnormal findings were noted in 86(74.14%) patients including 45 (38.79%) patients with gastric erosions, 30 (25.86%) patientswith peptic ulcer and 11 (9.48%) patients were found with gastric malignancy. Conclusions:Upper gastrointestinal lesions are common in elderly patients with iron deficiency anemiapresenting with dyspepsia and must be screened by gastrointestinal endoscopy.


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