Chronic Invasive Fungal Rhinosinusitis: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Nrusheel Kattar ◽  
Basit Jawad ◽  
Muhib Haidari ◽  
Ryan Winters
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Fungal Rhinosinusitis ◽  
Invasive Fungal Rhinosinusitis ◽  
Chronic Invasive

scholarly journals Allergen Immunotherapy in an HIV+ Patient with Allergic Fungal Rhinosinusitis

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Ian A. Myles ◽  
Satyen Gada
Keyword(s):  
Allergen Immunotherapy ◽  
Severe Infection ◽  
Invasive Fungal Disease ◽  
Fungal Disease ◽  
Fungal Sinusitis ◽  
Opportunistic Pathogens ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Invasive Fungal Rhinosinusitis ◽  
Chronic Invasive

Patients with HIV/AIDS can present with multiple types of fungal rhinosinusitis, fungal balls, granulomatous invasive fungal rhinosinusitis, acute or chronic invasive fungal rhinosinusitis, or allergic fungal rhinosinusitis (AFRS). Given the variable spectrum of immune status and susceptibility to severe infection from opportunistic pathogens it is extremely important that clinicians distinguish aggressive fungal invasive fungal disease from the much milder forms such as AFRS. Here we describe a patient with HIV and AFRS to both remind providers of the importance of ruling out invasive fungal disease and outline the other unique features of fungal sinusitis treatment in the HIV-positive population. Additionally we discuss the evidence for and against use of allergen immunotherapy (AIT) for fungal disease in general, as well as the evidence for AIT in the HIV population.

Chronic Invasive Fungal Rhinosinusitis: Two New Cases and Review of the Literature

2004 ◽  
Vol 18 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Xavier Dufour ◽  
Catherine Kauffmann-Lacroix ◽  
France Roblot ◽  
Jean Michel Goujon ◽  
Jean Philippe Breux ◽  
...  
Keyword(s):  
Review Of The Literature ◽  
Fungal Rhinosinusitis ◽  
Invasive Fungal Rhinosinusitis ◽  
Chronic Invasive

Fungal diseases of the ear, nose, and throat

2017 ◽  
Author(s):  
Arunaloke Chakrabarti
Keyword(s):  
Invasive Disease ◽  
Sinus Disease ◽  
Laryngeal Diseases ◽  
Non Invasive ◽  
Fungal Rhinosinusitis ◽  
Acute Invasive Fungal Rhinosinusitis ◽  
Invasive Infections ◽  
Invasive Fungal Rhinosinusitis ◽  
Chronic Invasive ◽  
Nose And Throat

Fungal infection of the ear (otomycosis), nose (fungal rhinosinusitis), and throat (oropharyngeal candidiasis) are common diseases. Fungal laryngeal diseases and invasive otomycosis & acute fungal rhinosinusitis are much less common and occur in immunosuppressed hosts, including those with diabetes. Aspergillus and Candida spp. are the commonest causes of otomycosis, whilst Aspergillus spp. predominate in sinus disease, with members of the Mucorales also causing serious invasive infections. Management of the non-invasive conditions can be difficult, and otomycosis and rhinosinusitis often become chronic. Invasive disease usually requires surgical intervention along with appropriate antifungal therapy. Acute invasive fungal rhinosinusitis has a mortality of approximately 50%.

scholarly journals Acute versus Chronic Invasive Fungal Rhinosinusitis: A Case-Control Study

2012 ◽  
Vol 5 ◽  
pp. IDRT.S9818 ◽  
Author(s):  
Patorn Piromchai ◽  
Sanguansak Thanaviratananich
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Immunocompromised Patients ◽  
Fungal Rhinosinusitis ◽  
Sinus Wall ◽  
Significant Difference ◽  
Mucosal Necrosis ◽  
Control Study ◽  
Invasive Fungal Rhinosinusitis ◽  
Chronic Invasive

Introduction Invasive fungal rhinosinusitis is a challenging condition that can be found mostly in immunocompromised patients. Failure to diagnose and treat this entity promptly usually results in rapid progression and death. The purpose of this study was to determine clinical presentation, complication and morbidity in patients with acute versus chronic invasive fungal rhinosinusitis. Setting and design Case-control study at Srinagarind Hospital, Khon Kaen University between January 1998 and May 2008. Methods The patient's data with the diagnosis of invasive fungal rhinosinusitis was included. Demographic data, underlying diseases, presenting symptoms, histologic sinonasal tissue evaluations, sinonasal tissue cultures, CT scan findings, surgical interventions, morbidity, and mortality were collected. Results Sixty-five patients were diagnosed as invasive fungal rhinosinusitis between January 1998 and May 2008. The data of six patients were unable to obtain. Fifty-nine patients were included in this study. Patients with immunocompromised status have significant greater risk for acute than chronic IFS, OR = 6.5 ( P = 0.004). Patients with mucosal necrosis have the significant higher risk for acute IFS, OR = 5.5 ( P = 0.01). There was no significant difference in orbital complications proportion between acute and chronic invasive fungal rhinosinusitis, OR = 2.42 ( P = 0.15). Sinus wall erosion have found significantly in chronic IFS group, OR = 0.24 ( P = 0.02). The average hospital stayed was 30.58 ± 26.43 days with no difference between groups ( P = 0.50). Fourteen patients in acute IFS group were dead (31.11%) while all patients in chronic IFS group were survived. Conclusions Invasive fungal rhinosinusitis continues to present a challenge to the otolaryngologist. Acute IFS was found most commonly in immunocompromised patients. The most consistent finding of acute IFS was mucosal necrosis and black crust/debris. The CT finding of sinus wall erosion may help in diagnosis of chronic IFS.

Fungal Rhinosinusitis: A Radiological Review with Intraoperative Correlation

2017 ◽  
Vol 68 (2) ◽  
pp. 178-186 ◽  
Author(s):  
Elaine Ni Mhurchu ◽  
Javier Ospina ◽  
Arif S. Janjua ◽  
Jason R. Shewchuk ◽  
Alexandra T. Vertinsky
Keyword(s):  
Invasive Disease ◽  
Clinical Severity ◽  
Fungal Colonization ◽  
Tissue Destruction ◽  
Tissue Invasion ◽  
Fungal Rhinosinusitis ◽  
Clinical Presentations ◽  
Invasive Fungal Rhinosinusitis ◽  
Chronic Invasive ◽  
Histopathological Evidence

The interaction between fungi and the sinonasal tract results in a range of clinical presentations with a broad spectrum of clinical severity. The most commonly accepted classification system divides fungal rhinosinusitis into invasive and noninvasive subtypes based on histopathological evidence of tissue invasion by fungi. Invasive fungal rhinosinusitis is subdivided into acute invasive and chronic invasive categories. The chronic invasive category includes a subcategory of chronic granulomatous disease. Noninvasive fungal disease includes localized fungal colonization, fungal ball, and allergic fungal rhinosinusitis. Noninvasive disease is simply fungal material (or the products of the inflammatory reaction of the sinus mucosa) that fills the sinuses but does not invade tissue. Bone loss is related to expansion of the sinus(es). Invasive disease causes tissue destruction, such that it expands past the bony confines of the sinuses. It can rapidly spread, causing acute necrosis. Alternatively, there may be slow tissue invasion characterized by symptoms confused with normal sinusitis, but destruction of normal nasal and paranasal structures.

scholarly journals Entities of Chronic and Granulomatous Invasive Fungal Rhinosinusitis: Separate or Not?

2018 ◽  
Vol 5 (10) ◽  
Author(s):  
Ling-Hong Zhou ◽  
Xuan Wang ◽  
Rui-Ying Wang ◽  
Hua-Zhen Zhao ◽  
Ying-Kui Jiang ◽  
...  
Keyword(s):  
Treatment Options ◽  
Tertiary Hospital ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Fungal Rhinosinusitis ◽  
Significant Difference ◽  
Clinical Considerations ◽  
Invasive Fungal Rhinosinusitis ◽  
Chronic Invasive

Abstract Background Chronic and granulomatous invasive fungal rhinosinusitis are important causes of blindness and craniocerebral complications. However, the classification of these 2 diseases remains controversial. Methods We retrospectively analyzed patients with chronic and granulomatous invasive fungal rhinosinusitus in a Chinese tertiary hospital from 2009 to 2017, with a focus on classification and comparisons. Results Among 55 patients enrolled in our study, 11 (11/55, 20%) had granulomatous invasive fungal rhinosinusitis (GIFRS) and 44 (44/55, 80%) had chronic invasive fungal rhinosinusitis (CIFRS). Aspergillus fumigatus and Dematiaceous hyphomycetes were identified in 2 patients with GIFRS. Compared with granulomatous type, CIFRS was more frequently encountered in immunocompromised patients (P = .022), and the time from onset to diagnosis was much shorter (P = .001). Proptosis and orbital apex syndrome showed no significant difference between granulomatous and CIFRS in our study. The treatment options and prognosis of both diseases also showed no significant difference. Conclusions Despite the consensus on histopathology, the classification of the chronic and granulomatous types may need further evaluation in clinical considerations.

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