scholarly journals Vitamin D Status in Children with Idiopathic Dilated Cardiomyopathy

2021 ◽  
Vol 11 (01) ◽  
pp. e120-e124
Author(s):  
Duaa M. Raafat ◽  
Osama M. EL-Asheer ◽  
Amal A. Mahmoud ◽  
Manal M. Darwish ◽  
Naglaa S. Osman
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Dilated Cardiomyopathy ◽  
Smooth Muscles ◽  
Left Ventricular ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Vitamin D Receptors ◽  
Left Ventricular Dimensions ◽  
And Function ◽  
Ventricular Dimensions

AbstractDilated cardiomyopathy (DCM) is the third leading cause of heart failure in pediatrics. The exact etiology of DCM is unknown in more than half of the cases. Vitamin D receptors are represented in cardiac muscles, endothelium, and smooth muscles of blood vessels suggesting that vitamin D could have a vital cardioprotective function. This study aimed to assess serum level of vitamin D in children with idiopathic DCM and to correlate the serum level of vitamin D with the left ventricular dimensions and function. This study is a descriptive cross-sectional single-center study, includes 44 children of both sexes, diagnosed as idiopathic DCM. Serum level of vitamin D was assessed and correlated with the left ventricular dimensions and function. Mean age of studied children was 6.08 ± 4.4 years. Vitamin D deficiency was found in 90.9% of children with idiopathic DCM with a mean level 13.48 ng/mL. There was a negative correlation between vitamin D level and fraction shortening and left ventricular end-diastolic diameter in children with DCM. Vitamin D level is not only significantly low in children with idiopathic DCM but it is also significantly correlated with the degree of left ventricular dysfunction.

Measurement of left ventricular dimensions and function in patients with dilated cardiomyopathy

2001 ◽  
Vol 13 (3) ◽  
pp. 367-371 ◽  
Author(s):  
Oliver Strohm ◽  
Jeanette Schulz-Menger ◽  
Bernhard Pilz ◽  
Karl-Josef Osterziel ◽  
Rainer Dietz ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Left Ventricular ◽  
Left Ventricular Dimensions ◽  
And Function ◽  
Ventricular Dimensions

Changes in human Golgi apparatus reflect new left ventricular dimensions and function in dilated cardiomyopathy patients

2016 ◽  
Vol 19 (2) ◽  
pp. 280-282 ◽  
Author(s):  
Estefanía Tarazón ◽  
Esther Roselló‐Lletí ◽  
Ana Ortega ◽  
Carolina Gil‐Cayuela ◽  
José Ramón González‐Juanatey ◽  
...  
Keyword(s):  
Golgi Apparatus ◽  
Dilated Cardiomyopathy ◽  
New Left ◽  
Left Ventricular ◽  
Left Ventricular Dimensions ◽  
And Function ◽  
Ventricular Dimensions

Left ventricular dimensions and function

2015 ◽  
pp. 7-20
Author(s):  
Helen Rimington ◽  
John B. Chambers
Keyword(s):  
Left Ventricular ◽  
Left Ventricular Dimensions ◽  
And Function ◽  
Ventricular Dimensions

Normal left ventricular dimensions and function: interstudy reproducibility of measurements with cine MR imaging.

Radiology ◽  
1990 ◽  
Vol 174 (3) ◽  
pp. 763-768 ◽  
Author(s):  
R C Semelka ◽  
E Tomei ◽  
S Wagner ◽  
J Mayo ◽  
C Kondo ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Left Ventricular ◽  
Cine Mr ◽  
Normal Left Ventricular ◽  
Left Ventricular Dimensions ◽  
And Function ◽  
Ventricular Dimensions

Abstract 4952: Differential Expression in the Determinants of Extracellular Matrix Remodeling in Pediatric and Adult Dilated Cardiomyopathy

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Tain-Yen Hsia ◽  
Jeremy M Ringewald ◽  
Robert E Stroud ◽  
Michael C Graves ◽  
Scott M Bradley ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Dilated Cardiomyopathy ◽  
Cell Lineage ◽  
Left Ventricular ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Matrix Remodeling ◽  
Adult Age ◽  
Membrane Type ◽  
And Function ◽  
Aggressive Clinical Course

Ventricular phenotype of idiopathic dilated cardiomyopathy (DCM) can appear similar in pediatric and adult patients, but a more aggressive clinical course often occurs with pediatric DCM. A structural underpinning of DCM is extracellular matrix changes, which are determined by a balance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs). This study tests the hypothesis that different MMP/TIMP profiles occur in pediatric and adult DCM patients. Left ventricular samples were taken from pediatric (age 12±4 yr; n=5) and adult (age 63±3 yr; n=11) patients during heart transplantation for DCM. Myocardial levels were quantified for all MMP classes: gelatinases (MMP-2, -9), collagenases (MMP-8, -13), lysins (MMP-7), membrane-type (MT1-MMP), and for all 4 known TIMPs. Patients with structural or ischemic etiologies of DCM were excluded. Compared to adults, MMP-8 levels increased by over 350% (Figure ), and MMP-7 and MT1-MMP levels (75±9% and 76±9%, respectively; p<0.05) were lower in pediatric patients. In contrast, pediatric TIMP-1 levels were reduced by over 50% (Figure). Pediatric DCM patients manifest a robust increase in MMP-8, which degrades all components of the extracellular matrix, and a decrease in TIMP-1, which inhibits MMP-8. This heightened MMP-8/TIMP-1 ratio would favor aggressive matrix remodeling in pediatric DCM. Since MMP-8 is primarily expressed by macrophage cell lineage, a unique proteolytic program may exist in pediatric DCM. These distinct differences in determinants of myocardial matrix structure and function likely contribute to the more progressive nature of DCM in children.

Automated, on-line quantification of left ventricular dimensions and function by echocardiography with backscatter imaging and lateral gain compensation

1992 ◽  
Vol 70 (13) ◽  
pp. 1200-1205 ◽  
Author(s):  
Julio E. Pérez ◽  
Steve C. Klein ◽  
David M. Prater ◽  
Carolyn E. Fraser ◽  
Hiram Cardona ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Left Ventricular Dimensions ◽  
On Line ◽  
Gain Compensation ◽  
And Function ◽  
Ventricular Dimensions
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