Survival Outcome of Sepsis in Recipients of Solid Organ Transplant

AbstractSepsis is a complex disease stemming from a dysregulated immune response toward an infectious agent. In transplantation, sepsis remains one of the leading causes of morbidity and mortality. Solid organ transplant recipients have impaired adaptive immunity due to immunosuppression required to prevent rejection. Immunosuppression has unintended consequences, such as increasing the risk of infections and sepsis. Due to its high morbidity and mortality, early detection of sepsis is paramount to start aggressive treatment. Several biomarkers or combination of biomarkers of sepsis have emerged in the last decade, but they are not dependable for early diagnosis or for outcome prognosis.

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Fatal Donor-Derived Carbapenem-ResistantKlebsiella pneumoniaeInfection in a Combined Kidney-Pancreas Transplantation

Case Reports in Transplantation ◽

10.1155/2016/7920951 ◽

2016 ◽

Vol 2016 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Giovanni Varotti ◽

Ferdinando Dodi ◽

Anna Marchese ◽

Alessia Terulla ◽

Massimo Bertocchi ◽

...

Keyword(s):

Pancreas Transplantation ◽

Organ Procurement ◽

Short Interval ◽

Organ Transplant ◽

Solid Organ Transplant ◽

High Morbidity ◽

Solid Organ ◽

Transplant Recipients ◽

Carbapenem Resistant ◽

Solid Organ Transplant Recipients

Carbapenem-resistantKlebsiella pneumoniae(CR-KP) infections in solid organ transplant recipients are associated with high morbidity and mortality. We report a case of a fatal donor-derived CR-KP infection in a combined kidney-pancreas transplant. Given the short interval of time between donor hospitalization and organ procurement, information concerning the donor CR-KP positivity arrived only 72 hours after transplant. Based on this experience, we believe that knowledge of the donor’s CR-KP status should be mandatory before procurement and, if positive, pancreas donation should be contraindicated.

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Malassezia restricta Pneumonia in Solid Organ Transplant Recipients: First Report of Two Cases

Journal of Fungi ◽

10.3390/jof7121057 ◽

2021 ◽

Vol 7 (12) ◽

pp. 1057

Author(s):

Alessandra Mularoni ◽

Elena Graziano ◽

Alice Annalisa Medaglia ◽

Barbara Buscemi ◽

Taylor Eddens ◽

...

Keyword(s):

Fungal Infections ◽

Solid Organ Transplantation ◽

Organ Transplant ◽

Solid Organ Transplant ◽

High Morbidity ◽

Solid Organ ◽

Transplant Recipients ◽

Solid Organ Transplant Recipients ◽

Emerging Fungal Infections ◽

Malassezia Restricta

Emerging fungal infections are a major challenge in solid organ transplantation (SOT) and are associated with high morbidity and mortality. We report two cases of Malassezia restricta pneumonia in SOT recipients. Infections were diagnosed with molecular analysis and histology. Patients were treated with antifungal therapy and have fully recovered.

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Meta-analysis of CMV-hyperimmune globulin studies for the prevention of CMV infection and disease in solid organ transplant recipients

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-2007-967308 ◽

2007 ◽

Vol 55 (S 1) ◽

Author(s):

N Bonaros ◽

A Kocher ◽

B Mayer ◽

G Laufer

Keyword(s):

Meta Analysis ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Cmv Infection ◽

Organ Transplant Recipients ◽

Hyperimmune Globulin ◽

Solid Organ Transplant Recipients

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A Model for Diagnosis of Pulmonary Infections in Solid-Organ Transplant Recipients

7th IFAC Symposium on Modelling and Control in Biomedical Systems ◽

10.3182/20090812-3-dk-2006.00060 ◽

2009 ◽

Author(s):

Kariv, Galia

Keyword(s):

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Pulmonary Infections ◽

Organ Transplant Recipients ◽

Solid Organ Transplant Recipients

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Faculty Opinions recommendation of Branch duct intraductal papillary mucinous neoplasm of the pancreas in solid organ transplant recipients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1162517.624057 ◽

2009 ◽

Author(s):

Brenda Hoffman

Keyword(s):

Intraductal Papillary Mucinous Neoplasm ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Branch Duct ◽

Organ Transplant Recipients ◽

Mucinous Neoplasm ◽

Solid Organ Transplant Recipients

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Faculty Opinions recommendation of Lipid formulations of amphotericin B significantly improve outcome in solid organ transplant recipients with central nervous system cryptococcosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1168228.734056 ◽

2009 ◽

Author(s):

Tania Sorrell ◽

Sharon Chen

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Amphotericin B ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Improve Outcome ◽

Solid Organ Transplant Recipients ◽

Lipid Formulations

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Faculty Opinions recommendation of A Double-Blind, Randomized Trial of High-Dose vs Standard-Dose Influenza Vaccine in Adult Solid-Organ Transplant Recipients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732320399.793545911 ◽

2018 ◽

Author(s):

Olivier Lortholary

Keyword(s):

Influenza Vaccine ◽

Randomized Trial ◽

Standard Dose ◽

Organ Transplant ◽

Solid Organ Transplant ◽

High Dose ◽

Solid Organ ◽

Transplant Recipients ◽

Double Blind ◽

Solid Organ Transplant Recipients

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Invasive fungal diseases in solid organ transplant recipients: recent progress in diagnosis and treatment

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2011.01361 ◽

2012 ◽

Vol 31 (12) ◽

pp. 1361-1365

Author(s):

Peng LIU ◽

Li ZENG ◽

You-hua ZHU

Keyword(s):

Recent Progress ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Fungal Diseases ◽

Diagnosis And Treatment ◽

Solid Organ ◽

Transplant Recipients ◽

Organ Transplant Recipients ◽

Invasive Fungal Diseases ◽

Solid Organ Transplant Recipients

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Cytomegalovirus in Solid Organ Transplant Recipients: Clinical Updates, Challenges and Future Directions

Current Pharmaceutical Design ◽

10.2174/1381612826666200531152901 ◽

2020 ◽

Vol 26 (28) ◽

pp. 3497-3506

Author(s):

Raymund R. Razonable

Keyword(s):

Organ Transplantation ◽

Solid Organ Transplantation ◽

Organ Transplant ◽

Solid Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Cmv Infection ◽

Future Directions ◽

Prevention And Treatment ◽

Solid Organ Transplant Recipients

Cytomegalovirus is the classic opportunistic infection after solid organ transplantation. This review will discuss updates and future directions in the diagnosis, prevention and treatment of CMV infection in solid organ transplant recipients. Antiviral prophylaxis and pre-emptive therapy are the mainstays of CMV prevention, but they should not be mutually exclusive and each strategy should be considered depending on a specific situation. The lack of a widely applicable viral load threshold for diagnosis and preemptive therapy is emphasized as a major factor that should pave the way for an individualized approach to prevention. Valganciclovir and intravenous ganciclovir remain as drugs of choice for CMV management, and strategies for managing drug-resistant CMV infection are enumerated. There is increasing use of CMV-specific cell-mediated immune assays to stratify the risk of CMV infection after solid organ transplantation, and their potential role in optimizing CMV prevention and treatment efforts is discussed.

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