scholarly journals Cardiac Tuberculosis on 18F-FDG PET Imaging—A Great Masquerader of Cardiac Sarcoidosis

2021 ◽  
Author(s):  
Sumati Sundaraiya ◽  
Abubacker Sulaiman ◽  
Adhithyan Rajendran
Keyword(s):  
Pet Imaging ◽  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Granulomatous Inflammation ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Whole Body ◽  
Left Ventricular Myocardium ◽  
Fdg Uptake ◽  
18F Fdg

AbstractA young gentleman with suspected cardiac sarcoidosis and LV dysfunction whose CMR revealed multifocal subepicardial to mid myocardial linear enhancement in the left ventricular myocardium underwent cardiac 18F-FDG PET imaging. The images revealed patchy regions of increased FDG uptake involving the apical to mid anterolateral, mid to basal anteroseptal/ right ventricular and mildly increased FDG uptake in apical inferior segments of the LV myocardium concordant with CMR findings. Whole body PET CT imaging showed multiple hypermetabolic supra and infra diaphragmatic lymphadenopathy, with no pulmonary lesion identified. Biopsy from the left para aortic lymph node revealed necrotizing granulomatous inflammation consistent with tuberculosis. Based on the histopathological findings of the lymph nodes, diagnosis of cardiac tuberculosis was made, given the similar imaging appearances in both sarcoidosis and TB. This case highlights that cardiac TB although rare, should be included in the differential diagnosis in patients with suspected infiltrative cardiomyopathy, particularly in TB endemic regions.

P1806Diagnosis of isolated cardiac sarcoidosis using FDG-PET/CT on the basis of new guidelines

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H Kawai ◽  
M Sarai ◽  
Y Kato ◽  
H Naruse ◽  
J Ishii ◽  
...  
Keyword(s):  
Predictive Value ◽  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Left Ventricular ◽  
Diagnosis And Treatment ◽  
Fdg Uptake ◽  
Pet Ct ◽  
18F Fdg ◽  
New Guidelines ◽  
Fdg Pet Ct

Abstract Introduction Sarcoidosis is a systemic inflammatory disease which can involve any organs. The reported prevalence of isolated cardiac sarcoidosis (CS) varies widely because of the lack of an agreed definition of isolated CS (iCS). ICS was newly defined in the new guidelines for CS by Japanese Circulation Society. Purpose We aimed to examine the diagnostic accuracy of 18F-FDG PET/CT and the ratio of iCS in the whole CS by reviewing the patients with suspected CS undergoing the whole-body and cardiac FDG PET/CT scans. Methods We retrospectively reviewed 74 consecutive patients undergoing 18F-FDG PET/CT from 2013 to 2018 (mean age 60±14 years, 37 male) without the initiation of corticosteroid. Myocardial FDG uptake in CS was defined as a “focal” or “focal on diffuse” pattern. Systemic sarcoidosis (sCS) and iCS were diagnosed according to guidelines for the diagnosis and treatment of CS by Japanese Circulation Society. In short, iCS was diagnosed clinically when no clinical findings of sarcoidosis in any other organs and FDG uptake in heart were shown in addition to the following three of four criteria: high-grade atrioventricular block or fatal ventricular arrhythmia, structural abnormality, left ventricular contractile dysfunction, and delayed Gadolinium enhancement of myocardium on MRI. Results Of 31 patients with extra-cardiac sarcoidosis, 10 already met the diagnostic criteria of sCS before undergoing 18F-FDG PET/CT and 11 was newly diagnosed as sCS after FDG PET/CT. Of the remaining 43 without extra-cardiac sarcoidosis, 18 had FDG uptake in heart. Of 18 with FDG uptake in heart, iCS was diagnosed in 7, and sCS in 3 with extra-cardiac uptake of FDG as well as myocardium. Finally, 24 and 7 patients met the criteria of sCS and iCS based on the guideline, respectively. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FDG PET/CT for CS including sCS and iCS were 90, 87, 88, 85, and 92%, respectively. Conclusion The ratio of iCS on the basis of new guidelines for diagnosis and treatment of CS was 22% of the whole CS.

The Utility of Whole Body 18F-FDG PET-CT in Diagnosing Isolated Cardiac Sarcoidosis: The Western Australian Cardiac Sarcoid Study

2020 ◽  
Vol 29 (1) ◽  
pp. e1-e6 ◽  
Author(s):  
Lauren Giudicatti ◽  
James Marangou ◽  
David Nolan ◽  
Lawrence Dembo ◽  
Jay Baumwol ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Western Australian

scholarly journals Predictors of pathologic outcome of focal FDG uptake in the parotid gland identified on whole-body FDG PET imaging

2015 ◽  
Vol 39 (6) ◽  
pp. 1073-1079 ◽  
Author(s):  
Marc C. Mabray ◽  
Spencer C. Behr ◽  
David M. Naeger ◽  
Robert R. Flavell ◽  
Christine M. Glastonbury
Keyword(s):  
Parotid Gland ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Whole Body ◽  
Fdg Uptake

scholarly journals Assessment of left ventricular systolic and diastolic function in diabetic rat model using Electrocardiography-gated 18F-FDG PET imaging

2017 ◽  
Vol 2 (5) ◽  
pp. 193
Author(s):  
Eissler Christoph ◽  
Nobuyuki Hayakawa ◽  
Paula-Anahi Arias-Loza ◽  
Hiroshi Wakabayashi ◽  
Rudolf Werner ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Pet Imaging ◽  
Rat Model ◽  
Fdg Pet ◽  
Left Ventricular ◽  
Diabetic Rat ◽  
18F Fdg ◽  
Systolic And Diastolic Function ◽  
Diabetic Rat Model

scholarly journals Beyond lymph nodes: 18F-FDG PET/CT in detection of unusual sites of extranodal lymphoma

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Amal Ibrahim Ahmed Othman ◽  
Merhan Nasr ◽  
Moustafa Abdel-Kawi
Keyword(s):  
Fdg Pet ◽  
Whole Body ◽  
Normal Morphology ◽  
Fdg Uptake ◽  
Contrast Enhanced ◽  
Pet Ct ◽  
Disease Staging ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Histopathological Type

Abstract Background The purpose of this study was to compare between contrast-enhanced computer tomography (CE CT) and 18F-FDG PET/CT in the detection of extranodal involvement in lymphoma and to correlate between SUVmax of the extranodal lesion and the hottest LN. One hundred patients with pathologically proven lymphoma underwent whole body 18F-FDG PET/CT and CECT scans. Images were compared regarding the ability of detection of extranodal lymphomatous sites. Kappa agreement was applied to find the degree of agreement between both modalities. Pearson’s correlation was used for correlating SUVmax of the extranodal lesions and hottest LN. The degree of FDG uptake was correlated with histopathological type. Results There was a poor agreement between PET/CT and CECT in the detection of extranodal sites (k = 0.32). There was a significant positive moderate correlation between SUVmax of the extranodal lesions and hottest LN (r = 0.45). PET/CT study resulted in up staging of 10% and down staging of 5% of cases. Conclusion In lymphoma staging, FDG PET/CT enables more detection of extranodal involved sites that show normal morphology at CECT. It differentiates lymphomatous infiltration from benign causes of increased FDG uptake with subsequent proper disease staging.

scholarly journals The prognostic role of PET myocardial perfusion imaging in patients with cardiac sarcoidosis: a systematic review

2021 ◽  
Vol 22 (Supplement_3) ◽  
Author(s):  
AI Ahmed ◽  
A Tsehay ◽  
Y Han ◽  
T Alnabelsi ◽  
T Agrawal ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Cardiac Sarcoidosis ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Unknown Etiology ◽  
Composite Outcome ◽  
Prognostic Role ◽  
Fdg Uptake ◽  
Abnormal Metabolism

Abstract Funding Acknowledgements Type of funding sources: None. Background Sarcoidosis is a multi-systemic inflammatory disease of unknown etiology. Cardiac Sarcoidosis (CS) has been reported in as much as 25% of patients with systemic involvement. 18Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) has a high diagnostic sensitivity/specificity in the diagnosis of CS. Purpose The aim of this review is to summarize evidence on the prognostic role of FDG PET. Methods Studies were identified by searching MEDLINE from inception to October 2020. Medical Subject Headings (MeSH) terms for sarcoidosis; cardiac and FDG PET imaging were used. Studies of any design assessing the prognostic role of FDG PET in patients with either suspected or confirmed cardiac sarcoidosis imaging done at baseline were included. Abnormal PET was defined as abnormal metabolism (presence of focal or focal-on-diffuse uptake of FDG) OR abnormal metabolism and a perfusion defect. Studies reporting any outcome measure were included. Pooled risk ratio for the composite outcome of MACE was done. Results A total of 6 studies were selected for final inclusion (515 patients, 53.4% women, 19.8% racial minorities.) Studies were institution based, retrospective in design and enrolled consecutive patients. All were observational in nature and published in English. All studies used a qualitative assessment of PET scans (abnormal FDG uptake with or without abnormal perfusion). Two studies assessed quantitative metrics (summed stress score in segments with abnormal FDG uptake, standardized uptake value and cardiac metabolic activity.) All studies reported Major Adverse Cardiovascular Events (MACE) as a composite outcome. After a mean follow up ranging from 1.4 to 4.1 years, there were a total of 105 MACE. All studies included death (either all-cause death or sudden cardiac death) and ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation) as a component of MACE. Four of the six studies adjusted for several characteristics in their analysis. All four studies used Left Ventricular Ejection Fraction (LVEF). However, other adjustment variables were not consistent across studies. Five studies found a positive prognostic association with the primary outcome, two of which assessing right ventricular uptake. Conclusion Although available evidence indicates FDG PET can be used in the risk stratification of patients with CS, our findings show further studies are needed to quantify the effect in this patient group.

scholarly journals The physiological uptake pattern of 18F-FDG in the left ventricular myocardium of patients without heart disease

2014 ◽  
Vol 61 (1.2) ◽  
pp. 53-58 ◽  
Author(s):  
Hayato Nose ◽  
Hideki Otsuka ◽  
Yoichi Otomi ◽  
Kaori Terazawa ◽  
Shoichiro Takao ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Physiological Uptake ◽  
Uptake Pattern ◽  
18F Fdg
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