Higher concentration of matrix-metalloproteinase 1 (interstitial collagenase) in H. pylori-compared to NSAID-induced gastric ulcers

2000 ◽  
Vol 38 (11) ◽  
pp. 887-891 ◽  
Author(s):  
M Menges ◽  
C C Chan ◽  
M Zeitz ◽  
A Stallmach
Keyword(s):  
Matrix Metalloproteinase ◽  
Gastric Ulcers ◽  
Matrix Metalloproteinase 1 ◽  
H Pylori ◽  
Interstitial Collagenase

scholarly journals Expressions of MMPs and TIMP-1 in Gastric Ulcers May DifferentiateH. pylori-Infected from NSAID-Related Ulcers

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Hsiu-Chi Cheng ◽  
Hsiao-Bai Yang ◽  
Wei-Lun Chang ◽  
Wei-Ying Chen ◽  
Yi-Chun Yeh ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Epithelial Cells ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Immunohistochemical Staining ◽  
Gastric Ulcers ◽  
Matrix Metalloproteinase 1 ◽  
Two Factors ◽  
H Pylori

Background. Two major causes of gastric ulcers areHelicobacter pylori(H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) use.Aims. This study aimed to determine if there were different expressions of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) betweenH. pylori-infected and NSAID-related ulcers.Methods. The 126 gastric ulcer patients (H. pyloriinfectedn=46; NSAID relatedn=30; combined with two factorsn=50) provided ulcer and nonulcer tissues for assessment of MMP-3, -7, and -9 and TIMP-1 expression by immunohistochemical staining.Results. Gastric ulcer tissues had significantly higher MMP-3, -7, and -9 and TIMP-1 expressions than nonulcer tissues (P<0.05).H. pylori-infected gastric ulcers had even higher MMP-7, MMP-9, and TIMP-1 expressions in epithelial cells than NSAID-related gastric ulcers (P<0.05). In patients with the two combined factors, gastric ulcers expressed similar proportions of antral ulcers and MMP-7 and MMP-9 intensities to NSAID-related gastric ulcers, but lower MMP-9 and TIMP-1 thanH. pylori-infected gastric ulcers (P<0.05).Conclusions. H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers. In patients with the two combined factors, ulcer location and MMP-7 and MMP-9 intensities are similar to NSAID use.

scholarly journals An Autocrine/Paracrine Role of Human Decidual Relaxin. I. Interstitial Collagenase (Matrix Metalloproteinase-1) and Tissue Plasminogen Activator1

1997 ◽  
Vol 56 (4) ◽  
pp. 800-811 ◽  
Author(s):  
Xuejin Qin ◽  
Jermelina Garibay-Tupas ◽  
Pong Kian Chua ◽  
Leinani Cachola ◽  
Gillian D. Bryant-Greenwood
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 1 ◽  
Tissue Plasminogen ◽  
Interstitial Collagenase

scholarly journals Expression of Interstitial Collagenase (Matrix Metalloproteinase-1) in Gastric Cancers

1997 ◽  
Vol 88 (4) ◽  
pp. 401-406 ◽  
Author(s):  
Yoshihiko Sakurai ◽  
Yoshihide Otani ◽  
Kaori Kameyama ◽  
Yasuhiro Hosoda ◽  
Isao Okazaki ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Gastric Cancers ◽  
Matrix Metalloproteinase 1 ◽  
Interstitial Collagenase

Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions

1997 ◽  
Vol 68 (2) ◽  
pp. 246-251 ◽  
Author(s):  
Isabelle Kokorine ◽  
Michelle Nisolle ◽  
Jacques Donnez ◽  
Yves Eeckhout ◽  
Pierre J. Courtoy ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 1 ◽  
Interstitial Collagenase
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