Identification of multiple HSP60 epitopes in JIA and other autoimmune diseases: A promising avenue for antigen-specific immunotherapy

Extracellular vesicles (EVs) are important players in autoimmune diseases, both in disease pathogenesis and as potential treatments. EVs can transport autoimmune triggers throughout the body, facilitating the process of antigen presentation. Understanding the link between cellular stress and EV biogenesis and intercellular trafficking will advance our understanding of autoimmune diseases. In addition, EVs can also be effective treatments for autoimmune diseases. The diversity of cell types that produce EVs leads to a wide range of molecules to be present in EVs, and thus EVs have a wide range of physiological effects. EVs derived from dendritic cells or mesenchymal stem cells have been shown to reduce inflammation. Since many autoimmune treatments are focused only on symptom management, EVs present a promising avenue for potential treatments. This review looks at the different roles EVs can play in autoimmune diseases, from disease pathology to diagnosis and treatment. We also overview various methodologies in isolating or generating EVs and look to the future for possible applications of EVs in autoimmune diseases.

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Major histocompatibility binding peptides: an experimental approach towards specific immunotherapy of autoimmune diseases

Autoimmunity: Experimental Aspects ◽

10.1007/978-3-642-78779-9_21 ◽

1994 ◽

pp. 259-273

Author(s):

Marca H. M. Wauben ◽

Willem van Eden

Keyword(s):

Autoimmune Diseases ◽

Experimental Approach ◽

Specific Immunotherapy ◽

Major Histocompatibility ◽

Binding Peptides

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Sa.37. Control of Autoimmune Diseases By Epitope Specific Immunotherapy

Clinical Immunology ◽

10.1016/j.clim.2006.04.269 ◽

2006 ◽

Vol 119 ◽

pp. S118

Author(s):

Rosario Billetta ◽

Mayuko Omori ◽

Allan Kaspar ◽

Negar Ghahramani ◽

Daniel Brigham ◽

...

Keyword(s):

Autoimmune Diseases ◽

Specific Immunotherapy

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Laryngeal Manifestations of Autoimmune Diseases

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2020_persp-19-00168 ◽

2020 ◽

Vol 5 (2) ◽

pp. 439-456

Author(s):

Jenny L. Pierce

Keyword(s):

Autoimmune Disease ◽

Autoimmune Diseases ◽

Patient Outcomes ◽

Correct Diagnosis ◽

Upper Airway ◽

Clinical Implications ◽

Laryngeal Function ◽

The Past ◽

Referral Practices ◽

Timely Referral

Purpose This review article provides an overview of autoimmune diseases and their effects on voice and laryngeal function. Method A literature review was conducted in PubMed. Combinations of the following keywords were used: “autoimmune disease and upper airway,” “larynx,” “cough,” “voice,” “dysphonia,” and “dyspnea.” Precedence was given to articles published in the past 10 years due to recent advances in this area and to review articles. Ultimately, 115 articles were included for review. Results Approximately 81 autoimmune diseases exist, with 18 of those highlighted in the literature as having laryngeal involvement. The general and laryngeal manifestations of these 18 are discussed in detail, in addition to the clinical implications for a laryngeal expert. Conclusions Voice, breathing, and cough symptoms may be an indication of underlying autoimmune disease. However, these symptoms are often similar to those in the general population. Appropriate differential diagnosis and timely referral practices maximize patient outcomes. Guidelines are provided to facilitate correct diagnosis when an autoimmune disease is suspected.

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