Leptin and soluble leptin receptor levels in patients with the polycystic ovary syndrome: influence of metabolic and endocrine parameters

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
S Hahn ◽  
U Haselhorst ◽  
A Schütz ◽  
S Tan ◽  
BL Herrmann ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Leptin Receptor ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Soluble Leptin Receptor ◽  
Endocrine Parameters

scholarly journals Decreased soluble leptin receptor levels in women with polycystic ovary syndrome

2006 ◽  
Vol 154 (2) ◽  
pp. 287-294 ◽  
Author(s):  
Susanne Hahn ◽  
Uwe Haselhorst ◽  
Beate Quadbeck ◽  
Susanne Tan ◽  
Rainer Kimmig ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Body Fat ◽  
Leptin Receptor ◽  
Polycystic Ovary ◽  
Biologically Active ◽  
Leptin Resistance ◽  
Ovary Syndrome ◽  
Soluble Leptin Receptor ◽  
Endocrine Parameters

Objective: Polycystic ovary syndrome (PCOS) is associated with insulin resistance and a high incidence of obesity. Leptin, the product of the ob gene, is involved in the regulation of energy balance and obesity and circulates in both free and bound forms. The soluble leptin receptor (sOB-R) is the most important leptin-binding protein, thus influencing the biologically active free leptin level. Design: We assessed the correlation of metabolic and endocrine parameters with leptin and sOB-R levels in 122 PCOS women (aged 27 ± 5.7 years) and 81 healthy controls (aged 25 ± 4.0 years). Methods: Leptin and sOB-R levels were measured using ELISA kits. In addition, anthropometric variables, body fat and endocrine parameters were evaluated and a glucose tolerance test performed to assess indices of insulin resistance and glucose metabolism. Results: In PCOS patients, no correlation was found between leptin or sOB-R and parameters of hyper-androgenism. However, as expected, body mass index (BMI), body fat, waist circumference and indices of insulin resistance were significantly correlated with leptin in PCOS subjects and controls. In a subgroup analysis of lean, overweight and obese PCOS patients, significant differences were found in leptin (29.7 ± 20.7 vs 45.4 ± 25.0 vs 67.7 ± 28.8 ng/ml, P < 0.0001) and sOB-R (8.0 ± 3.4 vs 6.4 ± 2.5 vs 5.7 ± 2.3 ng/ml, P < 0.05). Compared with BMI-matched controls, lean PCOS patients had lower sOB-R levels (8.0 ± 3.4 vs 12.7 ± 4.7 ng/ml, P < 0.0001) and higher free leptin indices (4.5 ± 3.9 vs 2.8 ± 2.2, P = 0.0285). Conclusion: Taking into account that low sOB-R levels supposedly compensate diminished leptin action, PCOS per se might cause leptin resistance.

LEPRgene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women

2017 ◽  
Vol 14 (4) ◽  
pp. 299-307 ◽  
Author(s):  
Xiaoyu Tu ◽  
Chuanning Yu ◽  
Minzhi Gao ◽  
Yu Zhang ◽  
Zhaofeng Zhang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Leptin Receptor ◽  
Chinese Women ◽  
Polycystic Ovary ◽  
Han Chinese ◽  
Ovary Syndrome ◽  
Soluble Leptin Receptor

Effects of Metformin Treatment on Soluble Leptin Receptor Levels in Women with Polycystic Ovary Syndrome

2019 ◽  
Vol 39 (4) ◽  
pp. 609-614 ◽  
Author(s):  
Ru-biao Liu ◽  
Yi Liu ◽  
Li-qun Lv ◽  
Wei Xiao ◽  
Cheng Gong ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Leptin Receptor ◽  
Polycystic Ovary ◽  
Metformin Treatment ◽  
Ovary Syndrome ◽  
Soluble Leptin Receptor

Associations of Leptin Receptor and Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis

2019 ◽  
Vol 75 (1) ◽  
pp. 1-8
Author(s):  
Jialang Liang ◽  
Jiarong Lan ◽  
Min Li ◽  
Fang Wang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Leptin Receptor ◽  
Genetic Model ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Peroxisome Proliferator ◽  
Ovary Syndrome ◽  
Peroxisome Proliferator Activated Receptor ◽  
Subgroup Analyses ◽  
The Relationship

Background: Previous studies on associations of leptin receptor (LEPR) and peroxisome proliferator-activated receptor gamma (PPARG) polymorphisms with polycystic ovary syndrome (PCOS) yielded conflicting results. Objectives: In this meta-analysis, we aimed to better analyze the relationship between LEPR/PPARG polymorphisms and PCOS in a larger pooled population. Methods: We performed a systematic search of PubMed, Web of Science, Embase and CNKI. We calculated pooled ORs and 95% CIs to estimate associations between LEPR/PPARG polymorphisms and PCOS. Results: Totally, 33 eligible studies were included. A significant association with susceptibility to PCOS was observed for LEPR rs1137101 polymorphism under recessive genetic model (p = 0.002, OR 1.88, 95% CI 1.26–2.78, I2 = 42%) and for PPARG rs1801282 polymorphism under dominant (p = 0.007, OR 1.20, 95% CI 1.05–1.36, I2 = 49%), overdominant (p = 0.02, OR 0.85, 95% CI 0.74–0.97, I2 = 48%), and allele (p = 0.006, OR 1.18, 95% CI 1.05–1.33, I2 = 47%) genetic models in overall population. Further subgroup analyses by ethnicity revealed that LEPR rs1137101 and PPARG rs3856806 polymorphisms were both significantly associated with susceptibility to PCOS in Asians. No any positive results were detected in overall and subgroup analyses. Conclusions: Our meta-analysis suggested that LEPR rs1137101, PPARG rs1801282, and rs3856806 polymorphisms were all significantly associated with individual susceptibility to PCOS in certain populations.

scholarly journals Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Nasser M. Rizk ◽  
Elham Sharif
Keyword(s):  
Insulin Resistance ◽  
Leptin Receptor ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Compensatory Mechanism ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Soluble Leptin Receptor ◽  
Median Level ◽  
Male Sex

Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens.Methods. A cross-sectional study included 78 female students aged 17–25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed.Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98–48.04) and decreased sOB-R in ng/ml 11.47 (7.59–16.44) compared to lean PCOS 16.97 (10.60–45.55) for leptin and 16.62 (11.61–17.96) for sOB-R withpvalues 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected.Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

Sign in / Sign up

Export Citation Format

Share Document