Morinda citrifolia L. (Noni) is an annual plant, distributed in the tropical parts of the world. Chemical constituents such as flavonoids, alkaloids, terpenoids, sterols, and minerals have been isolated from this plant. The pharmacological properties, based on scientific research, claimed as antibacterial, antiulcerogenic, anti-inflammatory, antioxidant, and especially for antimelanogenesis therapy. Iridoid, a flavonoid compound, is the main component found in the Noni leaves extract. Screening of Noni leaves extract possessed flavonoid and steroid content with the concentration of 2.82% and 0.14%, respectively. Therefore, the Noni leaves extract was potential used for sunscreen, based on antimelanogenesis activity.