High Dose Supplementation of RRR-α-Tocopherol Decreases Cellular Hemostasis but Accelerates Plasmatic Coagulation in Type 2 Diabetes Mellitus

1999 ◽  
Vol 31 (12) ◽  
pp. 665-671 ◽  
Author(s):  
P. Ferber ◽  
K. Moll ◽  
T. Koschinsky ◽  
P. Rösen ◽  
F. Susanto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
High Dose ◽  
Plasmatic Coagulation

scholarly journals Protective Effects of Catechins Isolate From GMB4 Clone Green Tea Against EPC In Type 2 Diabetes Mellitus

Jurnal NERS ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. 247
Author(s):  
Yuly Peristiowati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Green Tea ◽  
Serum Levels ◽  
Control Group ◽  
High Dose ◽  
Protective Effects ◽  
Diabetes Mellitus Group

Introduction : This study aimed to evaluate the role of catechins isolates from GMB4 clone green to in the dynamics of endothelial progenitor cells (EPC) in type 2 diabetes mellitus (DM). Methods: 25 Wistar rats, were divided into 5 groups, including control group, type 2 diabetes mellitus group, treated daily administration of extracts of catechins isolate from GMB4 clones green tea at 20; 40; and 60 mg /kgBB doses for 6 weeks. EPCs analysis was performed by flow cytometry,levels of NO was performed using a spectrophotometer, serum levels of SDF-1a was performed with ELISA technique. Analysis of the expression of SDF-1 and CXCR-4 was performed using immunohistochemistry techniques. Results : The CD34+ and CD133+ count is lower in the DM group compared to the control group (P < 0.05). Of the three doses of catechins, only the highest dose were able to significantly increase CD34+ count compared to rats in the diabetes mellitus group (P < 0.05), Serum NO level is significantly higher in the DM the control group (P < 0.05). All three doses of catechins were able to significantly increase the expression of SDF-1a and CXCR4 in the aorta compared to the DM group or the control group (P < 0.05). Discussion :  It can be concluded that high dose cathecin isolate from GMB-4 clone green tea (60 mg/kgBB) may trigger the proliferation and maturation of EPCs in rats with type 2 DM in environment with high level of NO, involving the interacton between SDF-1a and CXCR4 in the aorta. 

scholarly journals A Case Report: An Overweight Patient with High Dose Insulin Usage

2021 ◽  
Vol 5 (4) ◽  
pp. 180-181
Author(s):  
Burcin Meryem Atak ◽  
◽  
Mustafa Ramiz Tel ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Aspart ◽  
Severe Hypoglycemia ◽  
Diabetes Mellitus Patient ◽  
Insulin Degludec ◽  
High Dose ◽  
Glucose Levels

Abstract: Insulin is vital for patients with type 1 diabetes and useful for certain patients with type 2 diabetes [1]. In this article we aim to explain a case wrongly using high dosage insulin. A 68-year-old female patient with known 10 years of type 2 diabetes mellitus and hypertension came to our outpatient clinic because her blood glucose levels were high at home. She was using perindopril 10 mg, metformin and insulin. Since the patient did not want to make multiple injections her previous doctor has changed her therapy from glargine u300 1x50 units and insulin aspart 3x30 units to a mixed insulin; insulin degludec + insulin aspart, as 2x 40 units per day. However, the patient did not understand the change of treatment and made the combination of insulin glargine u300 1x50 units and insulin degludec + insulin aspart two times a day as 30 units. She was using this therapy more than two months. Diabetes and complications of diabetes is a challenging healthcare problem. Especially patients’ education is as important as the drug therapy [2, 3]. Among serious side-effects of insulin therapy are overdose, resulting in severe hypoglycemia, causing seizures, coma and even death [1]. Patients must be well educated about the risks of using high doses of insulin. Keywords: High dose insulin, Obesity, Type 2 diabetes mellitus, Patient education, Hypoglycemia, Insulin overdose

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