Elevated Blood Pressure, Pulse Rate and Serum Creatinine in Negro Males Deficient in Glucose-6-Phosphate Dehydrogenase

1970 ◽  
Vol 282 (18) ◽  
pp. 1001-1002 ◽  
Author(s):  
Stephen L. Wiesenfeld ◽  
Nicholas L. Petrakis ◽  
Bruce J. Sams ◽  
Morris F. Collen ◽  
John L. Cutler
1982 ◽  
Vol 63 (s8) ◽  
pp. 403s-405s ◽  
Author(s):  
S. Freestone ◽  
L. E. Ramsay

1. Patients with mild hypertension who habitually smoked cigarettes and consumed caffeine were examined after abstaining from caffeine and cigarettes overnight. Their mean blood pressure (147/89 mmHg) was substantially lower than values recorded in the clinic (164/102 mmHg) and remained so when they continued to abstain (149/94 mmHg at 2 h). 2. Smoking two cigarettes (3.4 mg of nicotine) elevated blood pressure by 10/8 mmHg but for only 15 min. 3. Drinking coffee (200 mg of caffeine) elevated blood pressure by up to 10/7 mmHg between 1 and 2 h. 4. Combined coffee and cigarette smoking caused a sustained rise in blood pressure from 5 to 120 min to levels similar to those measured in the clinic (162/102 mmHg at 2 h). The interaction of coffee and cigarettes on blood pressure, but not on pulse rate, was significant. 5. Caffeine ingestion with or without smoking may be important in the genesis of mild hypertension.


1960 ◽  
Vol XXXIV (III) ◽  
pp. 411-429 ◽  
Author(s):  
Melvin J. Fregly ◽  
Kenneth M. Cook

ABSTRACT The anti-thyroid drugs, thiouracil, propylthiouracil, and methimazole, prevented both development of elevated blood pressure and cardiac hypertrophy usually accompanying kidney encapsulation with latex envelopes. These drugs also reduced elevated blood pressure of rats with hypertension of 13 to 40 weeks' duration prior to drug administration. Addition of desiccated thyroid powder to diet containing an anti-thyroid drug overcame the anti-hypertensive effect of the latter. Withdrawal of thyroid powder only was followed by return of blood pressure to previous low level within 3 weeks. The results suggest that the anti-hypertensive effect of these drugs is related directly to the hypothyroidism produced rather than to extrathyroidal effects of the drugs. Comparison of potencies of the 3 drugs in terms of anti-hypertensive effect, inhibition of growth rate, increase in testicular size, and increase in thyroid size suggests that propylthiouracil and methimazole are equally potent per unit weight of drug. Thiouracil has approximately half the potency of the other two.


Circulation ◽  
1997 ◽  
Vol 96 (4) ◽  
pp. 1082-1088 ◽  
Author(s):  
Catarina I. Kiefe ◽  
O. Dale Williams ◽  
Diane E. Bild ◽  
Cora E. Lewis ◽  
Joan E. Hilner ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document