Cigarette Smoking and Neoplasia of the Uterine Cervix: Smoke Constituents in Cervical Mucus

1985 ◽  
Vol 312 (5) ◽  
pp. 315-316 ◽  
Keyword(s):  
Cigarette Smoking ◽  
Uterine Cervix ◽  
Cervical Mucus

scholarly journals Determination of Cytokine Protein Levels in Cervical Mucus Samples from Young Women by a Multiplex Immunoassay Method and Assessment of Correlates

2007 ◽  
Vol 15 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Jay A. Lieberman ◽  
Anna-Barbara Moscicki ◽  
Jan L. Sumerel ◽  
Yifei Ma ◽  
Mark E. Scott
Keyword(s):  
Cigarette Smoking ◽  
Proinflammatory Cytokines ◽  
Female Genital Tract ◽  
Cervical Mucus ◽  
Anatomic Site ◽  
Cross Sectional ◽  
Suspension Array ◽  
Immunoregulatory Cytokines ◽  
Cytokine Levels ◽  
Ifn Γ

ABSTRACT Cytokines in cervical mucus are likely to play important roles in controlling pathogens. The cervical mucosal environment is complex, however, with many endogenous and exogenous factors that may affect cytokine levels. We used a multiplex, suspension-array-based immunoassay method to measure 10 proinflammatory (interleukin-1β [IL-1β], IL-6, and IL-8) and immunoregulatory (gamma interferon [IFN-γ], IL-2, IL-4, IL-5, IL-10, IL-12, and IL-13) cytokines in cervical mucus specimens collected via ophthalmic sponge from 72 healthy, nonpregnant women and correlate their levels with biologic and behavioral covariates in a cross-sectional design. Proinflammatory and immunoregulatory cytokines were readily detected, although proinflammatory cytokines were present at markedly higher levels than were immunoregulatory cytokines. Among the covariates examined, the most striking finding was the significant (P ≤ 0.05) association between depressed levels of the cytokines IFN-γ, IL-1β, IL-6, and IL-10 and cigarette smoking. Also, nonsignificant trends toward lower cytokine levels were found in the settings of incident and persistent human papillomavirus infection. The ready detection of proinflammatory cytokines may be reflective of the female genital tract as an anatomic site that is constantly exposed to immunogenic stimulation. Cigarette smoking appears to downregulate cytokine responses in the cervical mucosa, which may help explain the implicated role of tobacco use as a cofactor for cervical cancer development.

scholarly journals Cigarette smoking and cancer of the uterine cervix

1985 ◽  
Vol 51 (1) ◽  
pp. 139-141 ◽  
Author(s):  
E R Greenberg ◽  
M Vessey ◽  
K McPherson ◽  
D Yeates
Keyword(s):  
Cigarette Smoking ◽  
Uterine Cervix

The effect of cigarette smoking on cell proliferation in normal uterine cervix epithelium

2010 ◽  
Vol 284 (1) ◽  
pp. 119-123 ◽  
Author(s):  
Adriana Bittencourt Campaner ◽  
Aline Estefanes Eras ◽  
Camila Bianca Lecciolle Paganini ◽  
Maria Antonieta L. Galvão
Keyword(s):  
Cell Proliferation ◽  
Cigarette Smoking ◽  
Uterine Cervix

Depressive symptoms and cigarette smoking in twins from the National Longitudinal Study of Adolescent Health.

2008 ◽  
Vol 27 (3, Suppl) ◽  
pp. S207-S215 ◽  
Author(s):  
Jeanne M. McCaffery ◽  
George D. Papandonatos ◽  
Cassandra Stanton ◽  
Elizabeth E. Lloyd-Richardson ◽  
Raymond Niaura
Keyword(s):  
Depressive Symptoms ◽  
Longitudinal Study ◽  
Cigarette Smoking ◽  
Adolescent Health ◽  
National Longitudinal Study
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