Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations

1993 ◽  
Vol 329 (13) ◽  
pp. 909-914 ◽  
Author(s):  
Michael J. Thirman ◽  
Heidi J. Gill ◽  
Robert C. Burnett ◽  
David Mbangkollo ◽  
Norah R. McCabe ◽  
...  
Keyword(s):  
Chromosomal Translocations ◽  
Mll Gene ◽  
Myeloid Leukemias ◽  
Acute Myeloid

scholarly journals Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts

Blood ◽  
2007 ◽  
Vol 110 (3) ◽  
pp. 799-805 ◽  
Author(s):  
Luke F. Peterson ◽  
Anita Boyapati ◽  
Eun-Young Ahn ◽  
Joseph R. Biggs ◽  
Akiko Joo Okumura ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Fusion Proteins ◽  
Myeloid Leukemia ◽  
Chromosomal Translocation ◽  
Chromosome 8 ◽  
Chromosome 21 ◽  
Chromosomal Translocations ◽  
Runx1 Gene ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Abstract Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.

Expression pattern of the septin gene family in acute myeloid leukemias with and without MLL-SEPT fusion genes

2010 ◽  
Vol 34 (5) ◽  
pp. 615-621 ◽  
Author(s):  
Joana Santos ◽  
Nuno Cerveira ◽  
Susana Bizarro ◽  
Franclim R. Ribeiro ◽  
Cecília Correia ◽  
...  
Keyword(s):  
Gene Family ◽  
Expression Pattern ◽  
Fusion Genes ◽  
Myeloid Leukemias ◽  
Acute Myeloid

The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0

2010 ◽  
Vol 91 (2) ◽  
pp. 303-309 ◽  
Author(s):  
Ritsuro Suzuki ◽  
Shigeki Ohtake ◽  
Jin Takeuchi ◽  
Masami Nagai ◽  
Yoshihisa Kodera ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Unrelated clonal chromosome abnormalities in myelodysplastic syndromes and acute myeloid leukemias

2002 ◽  
Vol 132 (2) ◽  
pp. 156-158 ◽  
Author(s):  
Jin-Yeong Han ◽  
Kyeong-Hee Kim ◽  
Hyuk-Chan Kwon ◽  
Jae-Seok Kim ◽  
Hyo-Jin Kim ◽  
...  
Keyword(s):  
Myelodysplastic Syndromes ◽  
Chromosome Abnormalities ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Acute Myeloid Leukemias

2007 ◽  
pp. 767-775
Author(s):  
Iris T. Chan ◽  
D. Gary Gilliland
Keyword(s):  
Myeloid Leukemias ◽  
Acute Myeloid

scholarly journals CLL dedifferentiation to clonally related myeloid cells

2020 ◽  
Vol 4 (24) ◽  
pp. 6169-6174
Author(s):  
Qianze Dong ◽  
Yan Xiu ◽  
Aaron Bossler ◽  
Sergei Syrbu ◽  
Hongming Wang ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Progenitor Cells ◽  
Myeloid Cells ◽  
Lymphocytic Leukemia ◽  
Key Points ◽  
Myeloid Leukemias ◽  
Acute Myeloid

Key Points Common progenitor cells exist in clonally related concomitant chronic lymphocytic leukemia and acute myeloid leukemias. CLL cells dedifferentiated to clonally related myeloid cells posttransplantation.

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