Book Review Apoptosis and Cancer Therapy: From Cutting-Edge Science to Novel Therapeutic Concepts Edited by Klaus-Michael Debatin and Simone Fulda. 1129 pp., in two volumes, illustrated. Weinheim, Germany, Wiley-VCH, 2006. $565. 3-527-31237-4

2006 ◽  
Vol 355 (25) ◽  
pp. 2711-2712
Author(s):  
Alex Philchenkov
Keyword(s):  
Cancer Therapy ◽  
Cutting Edge ◽  
Therapeutic Concepts ◽  
Novel Therapeutic

Humanized tumor mice–a new cutting-edge model to study immune responses in advanced cancer therapy

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
A Krömer ◽  
G Brockhoff ◽  
A Wege
Keyword(s):  
Cancer Therapy ◽  
Immune Responses ◽  
Advanced Cancer ◽  
Cutting Edge

scholarly journals The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

Biology ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 485
Author(s):  
Lorenzo Cuollo ◽  
Fabrizio Antonangeli ◽  
Angela Santoni ◽  
Alessandra Soriani
Keyword(s):  
Cancer Therapy ◽  
Molecular Mechanisms ◽  
Therapeutic Strategies ◽  
Senescent Cell ◽  
Pharmacological Intervention ◽  
Tissue Microenvironment ◽  
Age Related ◽  
Secretory Phenotype ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP), which entails the copious secretion of proinflammatory signals in the tissue microenvironment and contributes to age-related conditions, including, paradoxically, cancer. Novel therapeutic strategies aim at eliminating senescent cells with the use of senolytics or abolishing the SASP without killing the senescent cell with the use of the so-called “senomorphics”. In addition, recent works demonstrate the possibility of modifying the composition of the secretome by genetic or pharmacological intervention. The purpose is not to renounce the potent immunostimulatory nature of SASP, but rather learning to modulate it for combating cancer and other age-related diseases. This review describes the main molecular mechanisms regulating the SASP and reports the evidence of the feasibility of abrogating or modulating the SASP, discussing the possible implications of both strategies.

Bispecific antibodies in colorectal cancer therapy: recent insights and emerging concepts

Immunotherapy ◽  
2021 ◽  
Author(s):  
Farideh Ghalamfarsa ◽  
Seyyed Hossein Khatami ◽  
Omid Vakili ◽  
Mortaza Taheri-Anganeh ◽  
Amir Tajbakhsh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Therapy ◽  
Large Family ◽  
Bispecific Antibodies ◽  
Health Concern ◽  
Vast Array ◽  
Tumor Associated Antigen ◽  
Therapeutic Procedures ◽  
Life Threatening ◽  
Novel Therapeutic

Colorectal cancer (CRC) is identified as a life-threatening malignancy. Despite several efforts and proceedings available for CRC therapy, it is still a health concern. Among a vast array of novel therapeutic procedures, employing bispecific antibodies (BsAbs) is currently considered to be a promising approach for cancer therapy. BsAbs, as a large family of molecules designed to realize two distinct epitopes or antigens, can be beneficial microgadgets to target the tumor-associated antigen pairs. On the other hand, applying the immune system's capabilities to attack malignant cells has been proven as a tremendous development in cancer therapeutic projects. The current study has attempted to overview some of the approved BsAbs in CRC therapy and those under clinical trials. For this purpose, reputable scientific search engines and databases, such as PubMed, ScienceDirect, Google Scholar, Scopus, etc., were explored using the keywords ‘bispecific antibodies’, ‘colorectal cancer’, ‘immunotherapy’ and ‘tumor markers’.

Book Review: DNA Repair in Cancer Therapy

2004 ◽  
Vol 90 (3) ◽  
pp. 365-365
Keyword(s):  
Dna Repair ◽  
Cancer Therapy

A strategy using mesoporous polymer nanospheres as nanocarriers of Bcl-2 siRNA towards breast cancer therapy

2019 ◽  
Vol 7 (3) ◽  
pp. 477-487 ◽  
Author(s):  
Xin Wu ◽  
Yawen Zheng ◽  
Dan Yang ◽  
Taijun Chen ◽  
Bo Feng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Breast Cancer Therapy ◽  
Mesoporous Polymer ◽  
Polymer Nanospheres ◽  
Novel Therapeutic

Synthesis and functionalization of a novel therapeutic nanoplatform available for cancer therapy.

Book Review: Camptothecins in Cancer Therapy

2005 ◽  
Vol 91 (5) ◽  
pp. 445-445
Keyword(s):  
Cancer Therapy
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