Based on the relation between regional land use structure and sustainable utilization for land resources, we analyze the land use structure in Xuzhou City by entropy theory and GM(1,1) model in this paper. The results shows that Xuzhou information entropy is increasing year by year, the land use structure in Xuzhou city develops gradually from order to a relatively disorder state, the equilibrium degree is increasing and dominance degree is decreasing year by year. That shows that the land use structure in Xuzhou City is evolving to equilibrium state. So the shortage of land resources in Xuzhou city will become more and more prominent, and adjust strategy of regional development urgent needed.