Water resource management and optimum use of all available water resources are ways for the adaptation of climate change and drought conditions.Weather modification, commonly known as cloud seeding, is the application of scientific technology that can enhance a cloud's ability to produce precipitation. Cloud seeding projects have being performed in Iran since 1999, as one of the most important strategies to increase water supplies. However, determining the time and place of cloud seeding operation are the basic necessities to achieve the best possible results. This paper explains innovative and scientific methods of feasibility study of Tehran province (semi-arid area) and Hormozgan province (arid area) by meteorological stations data, upper air data, satellite imagery (TRMM), weather radars products, topographic and vegetation maps. Factor analysis and World Meteorological Organization classification methods of PEP were applied to determine proper seeding time. Eventually, cloud seeding susceptible areas were classified as levels and altitudes. In Tehran province, the results showed that the northwest, west and central catchments are capable for cloud seeding operation in December, January, February and March at an altitude of 2500-3000 meters. Suitable months of cloud seeding operation in the north and northwest of the catchment of Hormozgan province were January, February and March, in order of priority.