Thermodynamic driving forces for shape changes and diffusion in nonhydrostatically stressed solids

1973 ◽  
Vol 44 (12) ◽  
pp. 5245-5253 ◽  
Author(s):  
F. V. Nolfi
Development ◽  
1993 ◽  
Vol 118 (3) ◽  
pp. 1013-1023 ◽  
Author(s):  
D. A. Clausi ◽  
G. W. Brodland

Current theories about the forces that drive neurulation shape changes are evaluated using computer simulations. Custom, three-dimensional, finite element-based computer software is used. The software draws on current engineering concepts and makes it possible to construct a ‘virtual’ embryo with any user-specified mechanical properties. To test a specific hypothesis about the forces that drive neurulation, the whole virtual embryo or any selected part of it is ascribed with the force generators specified in the hypothesis. The shape changes that are produced by these forces are then observed and compared with experimental data. The simulations demonstrate that, when uniform, isotropic circumferential microfilament bundle (CMB) constriction and cephalocaudal (axial) elongation act together on a circular virtual neural plate, it becomes keyhole shaped. When these forces act on a spherical (amphibian) embryo, dorsal surface flattening occurs. Simulations of transverse sections further show that CMB constriction, acting with or without axial elongation, can produce numerous salient transverse features of neurulation. These features include the sequential formation of distinct neural ridges, narrowing and thickening of the neural plate, skewing just medial to the ridges, ‘hinge’ formation and neural tube closure. No region-specific ‘programs’ or non-mechanical cell-cell communications are used. The increase in complexity results entirely from mechanical interactions. The transverse simulations show how changes to the driving forces would affect the patterns of shape change produced. Hypotheses regarding force generation by microtubules, intercellular adhesions and forces extrinsic to the neural plate are also evaluated. The simulations show that these force-generating mechanisms do not, by themselves, produce shape changes that are consistent with normal development. The simulations support the concept of cooperation of forces and suggest that neurulation is robust because redundant force generating mechanisms exist.


2007 ◽  
Vol 264 ◽  
pp. 133-140
Author(s):  
Leonid Klinger ◽  
Eugen Rabkin

We considered a polycrystalline cylindrical nanowire with bamboo microstructure strained uniaxially by an external load. Our molecular dynamic computer simulations demonstrated that grain boundary grooving plays an important role in determining the morphological stability of nanowires. Also, an exceptionally high yield stress of nanowires emphasizes the importance of diffusion in their plastic deformation under applied load. We formulated a phenomenological diffusion-based model describing morphological stability and diffusion-controlled deformation behaviour of polycrystalline nanowires. The kinetics of the shape changes was calculated numerically.


2015 ◽  
Vol 6 (3) ◽  
pp. 1-20 ◽  
Author(s):  
Faouzi Kamoun ◽  
Sami Miniaoui

This paper aims to acquire underlying knowledge about the dynamics of RFID adoption and diffusion and explore the drivers that shape the RFID diffusion pathway. The paper uses a case study methodology to conduct and present the research and its findings. The paper presents an RFID adoption/diffusion model that can guide enterprises to transition from standalone RFID deployments towards new RFID systems that are deeply integrated with business processes. The diffusion process follows a three-stage model with isomorphic feedback mechanisms. The first stage is an isolated/sensing phase, the second stage is an absorptive phase, while the last stage is an integrative phase. The proposed model suggests that a combination of endogenous and exogenous factors constitute the driving forces behind each phase of the diffusion pathway. Our research reveals that some congruence between organizational and individual aims is plausible during the adoption phase and that RFID adoption can be initiated through organizational free-will as opposed to coercive pressures from influencing organizations.


1976 ◽  
Vol 32 ◽  
pp. 109-116 ◽  
Author(s):  
S. Vauclair

This paper gives the first results of a work in progress, in collaboration with G. Michaud and G. Vauclair. It is a first attempt to compute the effects of meridional circulation and turbulence on diffusion processes in stellar envelopes. Computations have been made for a 2 Mʘstar, which lies in the Am - δ Scuti region of the HR diagram.Let us recall that in Am stars diffusion cannot occur between the two outer convection zones, contrary to what was assumed by Watson (1970, 1971) and Smith (1971), since they are linked by overshooting (Latour, 1972; Toomre et al., 1975). But diffusion may occur at the bottom of the second convection zone. According to Vauclair et al. (1974), the second convection zone, due to He II ionization, disappears after a time equal to the helium diffusion time, and then diffusion may happen at the bottom of the first convection zone, so that the arguments by Watson and Smith are preserved.


Author(s):  
P. R. Okamoto ◽  
N.Q. Lam ◽  
R. L. Lyles

During irradiation of thin foils in a high voltage electron microscope (HVEM) defect gradients will be set up between the foil surfaces and interior. In alloys defect gradients provide additional driving forces for solute diffusion since any preferential binding and/or exchange between solute atoms and mobile defects will couple a net flux of solute atoms to the defect fluxes. Thus, during irradiation large nonequilibrium compositional gradients can be produced near the foil surfaces in initially homogeneous alloys. A system of coupled reaction-rate and diffusion equations describing the build up of mobile defects and solute redistribution in thin foils and in a semi-infinite medium under charged-particle irradiation has been formulated. Spatially uniform and nonuniform damage production rates have been used to model solute segregation under electron and ion irradiation conditions.An example calculation showing the time evolution of the solute concentration in a 2000 Å thick foil during electron irradiation is shown in Fig. 1.


2013 ◽  
Vol 18 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Robert J. Barth

Abstract Scientific findings have indicated that psychological and social factors are the driving forces behind most chronic benign pain presentations, especially in a claim context, and are relevant to at least three of the AMA Guides publications: AMA Guides to Evaluation of Disease and Injury Causation, AMA Guides to Work Ability and Return to Work, and AMA Guides to the Evaluation of Permanent Impairment. The author reviews and summarizes studies that have identified the dominant role of financial, psychological, and other non–general medicine factors in patients who report low back pain. For example, one meta-analysis found that compensation results in an increase in pain perception and a reduction in the ability to benefit from medical and psychological treatment. Other studies have found a correlation between the level of compensation and health outcomes (greater compensation is associated with worse outcomes), and legal systems that discourage compensation for pain produce better health outcomes. One study found that, among persons with carpal tunnel syndrome, claimants had worse outcomes than nonclaimants despite receiving more treatment; another examined the problematic relationship between complex regional pain syndrome (CRPS) and compensation and found that cases of CRPS are dominated by legal claims, a disparity that highlights the dominant role of compensation. Workers’ compensation claimants are almost never evaluated for personality disorders or mental illness. The article concludes with recommendations that evaluators can consider in individual cases.


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