Design of experiment of redispersible spray dried powder of fatty acid-nanostructured lipid carriers using a 23 full factorial design

2021 ◽  
Author(s):  
N. M. Noor ◽  
N. A. Anuar ◽  
Z. I. Abd-Rasid ◽  
N. Mohtar ◽  
R. Hasham
Keyword(s):  
Fatty Acid ◽  
Factorial Design ◽  
Design Of Experiment ◽  
Full Factorial Design ◽  
Nanostructured Lipid Carriers ◽  
Full Factorial ◽  
Spray Dried

Heat Treatment Map of Al2Ca-added AlSi11MnMg Pressure-Cast Alloy Plotted by Full Factorial Design of Experiment and Analysis of Variance

2019 ◽  
Vol 61 (7-8) ◽  
pp. 511-516
Author(s):  
Gil-Yong Yeom ◽  
G. Eisaabadi B. ◽  
Shae K. Kim ◽  
Soong-Keun Hyun ◽  
Kyeong Suk Sim ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Factorial Design ◽  
Analysis Of Variance ◽  
Design Of Experiment ◽  
Cast Alloy ◽  
Full Factorial Design ◽  
Full Factorial

scholarly journals Facile preparation of sago starch esters using full factorial design of experiment

2012 ◽  
Vol 64 (8) ◽  
pp. 590-597 ◽  
Author(s):  
Felycia Edi Soetaredjo ◽  
Suryadi Ismadji ◽  
Lien Huong Huynh ◽  
Novy S. Kasim ◽  
Ngoc Yen Tran-Thi ◽  
...  
Keyword(s):  
Factorial Design ◽  
Design Of Experiment ◽  
Full Factorial Design ◽  
Sago Starch ◽  
Facile Preparation ◽  
Full Factorial

Interaction Relationship Analysis of Surface Roughness on Aluminium Etched Wafer Using RIE

2014 ◽  
Vol 487 ◽  
pp. 214-217
Author(s):  
Zaliman Sauli ◽  
Vithyacharan Retnasamy ◽  
Aaron Koay Terr Yeow ◽  
Ng Wei Wei
Keyword(s):  
Surface Roughness ◽  
Factorial Design ◽  
Design Of Experiment ◽  
Reactive Ion Etching ◽  
Full Factorial Design ◽  
Strong Interactions ◽  
Rf Power ◽  
Ion Etching ◽  
Relationship Analysis ◽  
Full Factorial

This paper presents the interaction relationships between Tetrafluoromethane (CF4) gas, Oxygen (O2) gas, and RF power in response to the surface roughness of an Aluminium deposited wafer after being etched using Reactive Ion Etching (RIE). The investigation was done using the three factors full factorial design of experiment (DOE). Analysis was done qualitatively by plotting the main interaction plots. The results suggest that strong interactions are present between CF4 and RF power, CF4 and O2, and also O2 and RF power due to the intersection of the graphs. This implies that all three factors have interaction between each other towards the surface roughness on the deposited Aluminium after RIE.

scholarly journals Formulation and In Vitro Characterization of Raloxifene Nanostructured Lipid Carriers For Oral Delivery With Full Factorial Design-Based Studies Using Quality By Design (QbD) Approach

2020 ◽  
Vol 11 (4) ◽  
pp. 6417-6427
Author(s):  
Chintamani Panda ◽  
Sachinkumar Prabhubhai Chauhan ◽  
Krishnan Balamurugan
Keyword(s):  
Particle Size ◽  
Factorial Design ◽  
Dissolution Rate ◽  
Surfactant Concentration ◽  
Quality By Design ◽  
Full Factorial Design ◽  
Nanostructured Lipid Carriers ◽  
Solid Lipid ◽  
Lipid Ratio ◽  
Full Factorial

The main aim of the present study is to improve the dissolution rate of Raloxifene Hydrochloride by formulating nanostructured lipid carriers (NLC) using Quality by Design (QbD) approach. The formulations of NLC-RH were prepared by the ultrasonication method using stearic acid as solid lipid, medium-chain triglyceride as the liquid lipid and polysorbate 80 as the surface-active agent. Two most critical quality attributes (CQAs) for NLC-RH were particle size and entrapment efficiency. The other attributes of medium influence identified includes dissolution rate, zeta potential and particle size didtribution. The Critical Material Attributes (CMAs) identified were solid lipid/liquid lipid ratio and surfactant concentration. The time required for ultrasonication was selected as a Critical Process Parameter (CPP). The 23 full factorial design was used to evaluate the relationship between the CMAs and CPPs variable. Based on the experiments, the composition of the optimal formulation is achieved with solid lipid/liquid lipid ratio of 7:3 and 7 % of surfactant concentration with 15 min of ultrasonication time. The optimized formulation of NLC-RH was found to be with a mean particle size of 146 nm with narrow particle size distributions. From the above results, it is concluded that a promising Raloxifene HCl loaded NLC could give a novel and potential therapy for osteoporosis.

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