Role of ultrasound for Down syndrome screening in advanced maternal age

2001 ◽  
Vol 185 (5) ◽  
pp. 1028-1031 ◽  
Author(s):  
James F.X. Egan ◽  
Lillian Malakh ◽  
Garry W. Turner ◽  
Glenn Markenson ◽  
Joseph R. Wax ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Down Syndrome Screening

448 Cost analysis of down syndrome screening in the advanced maternal age population

2001 ◽  
Vol 185 (6) ◽  
pp. S205
Author(s):  
Janice Hartnett ◽  
Adam Borgida ◽  
Peter Benn ◽  
Michael Barsoom ◽  
Michael Deroche ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cost Analysis ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Down Syndrome Screening

Cost analysis of Down syndrome screening in advanced maternal age

2003 ◽  
Vol 13 (2) ◽  
pp. 80-84 ◽  
Author(s):  
J. Hartnett ◽  
A. F. Borgida ◽  
P. A. Benn ◽  
D. M. Feldman ◽  
M. E. DeRoche ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cost Analysis ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Down Syndrome Screening

The quadruple test for Down syndrome screening in pregnant women of advanced maternal age

2011 ◽  
Vol 285 (3) ◽  
pp. 629-633 ◽  
Author(s):  
Ji Young Kwon ◽  
In Yang Park ◽  
Seong-min Kwon ◽  
Chan Joo Kim ◽  
Jong Chul Shin
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Down Syndrome Screening

Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age

2014 ◽  
Vol 26 (8) ◽  
pp. 1072 ◽  
Author(s):  
Leanne Pacella-Ince ◽  
Deirdre L. Zander-Fox ◽  
Michelle Lane
Keyword(s):  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Protein Function ◽  
Maternal Age ◽  
Cumulus Cells ◽  
Advanced Maternal Age ◽  
Oocyte Quality ◽  
Carbamoyl Phosphate ◽  
Protein Activity

Women with reduced ovarian reserve or advanced maternal age have an altered metabolic follicular microenvironment. As sirtuin 5 (SIRT5) senses cellular metabolic state and post-translationally alters protein function, its activity may directly impact on oocyte viability and pregnancy outcome. Therefore, we investigated the role of SIRT5 in relation to ovarian reserve and maternal age. Women (n = 47) undergoing routine IVF treatment were recruited and allocated to one of three cohorts based on ovarian reserve and maternal age. Surplus follicular fluid, granulosa and cumulus cells were collected. SIRT5 mRNA, protein and protein activity was confirmed in granulosa and cumulus cells via qPCR, immunohistochemistry, western blotting and desuccinylation activity. The presence of carbamoyl phosphate synthase I (CPS1), a target of SIRT5, was investigated by immunohistochemistry and follicular-fluid ammonium concentrations determined via microfluorometry. Women with reduced ovarian reserve or advanced maternal age had decreased SIRT5 mRNA, protein and desuccinylation activity in granulosa and cumulus cells resulting in an accumulation of follicular-fluid ammonium, presumably via alterations in activity of a SIRT5 target, CPS1, which was present in granulosa and cumulus cells. This suggests a role for SIRT5 in influencing oocyte quality and IVF outcomes.

Nuchal thickness, urine β-core fragment level, and maternal age for Down syndrome screening

1999 ◽  
Vol 180 (2) ◽  
pp. 491-495 ◽  
Author(s):  
R.O. Bahado-Singh ◽  
A.U. Oz ◽  
D. Flores ◽  
D. Cermik ◽  
E. Acuna ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Maternal Age ◽  
Core Fragment ◽  
Down Syndrome Screening

The role of advanced maternal age and newborn sex in pregnancy outcome

2013 ◽  
Vol 3 (4) ◽  
pp. 159-164 ◽  
Author(s):  
Alessandro Favilli ◽  
Silvia Pericoli ◽  
Gian Carlo Di Renzo ◽  
Sandro Gerli
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
In Pregnancy

New estimates of down syndrome risks at chorionic villus sampling, amniocentesis, and livebirth in women of advanced maternal age from a uniquely defined population

1995 ◽  
Vol 15 (5) ◽  
pp. 455-465 ◽  
Author(s):  
Jane L. Halliday ◽  
Lyndsey F. Watson ◽  
Judith Lumley ◽  
David M. Danks ◽  
Leslie J. Sheffield
Keyword(s):  
Down Syndrome ◽  
Maternal Age ◽  
Chorionic Villus ◽  
Advanced Maternal Age ◽  
Chorionic Villus Sampling
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