Pregnancy and advanced maternal age – the role of regular exercise on maternal and infant health variables

2019 ◽  
Vol 22 ◽  
pp. S42
Author(s):  
L. Haakstad
Keyword(s):  
Maternal Age ◽  
Infant Health ◽  
Advanced Maternal Age ◽  
Regular Exercise ◽  
Maternal And Infant Health

Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age

2014 ◽  
Vol 26 (8) ◽  
pp. 1072 ◽  
Author(s):  
Leanne Pacella-Ince ◽  
Deirdre L. Zander-Fox ◽  
Michelle Lane
Keyword(s):  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Protein Function ◽  
Maternal Age ◽  
Cumulus Cells ◽  
Advanced Maternal Age ◽  
Oocyte Quality ◽  
Carbamoyl Phosphate ◽  
Protein Activity

Women with reduced ovarian reserve or advanced maternal age have an altered metabolic follicular microenvironment. As sirtuin 5 (SIRT5) senses cellular metabolic state and post-translationally alters protein function, its activity may directly impact on oocyte viability and pregnancy outcome. Therefore, we investigated the role of SIRT5 in relation to ovarian reserve and maternal age. Women (n = 47) undergoing routine IVF treatment were recruited and allocated to one of three cohorts based on ovarian reserve and maternal age. Surplus follicular fluid, granulosa and cumulus cells were collected. SIRT5 mRNA, protein and protein activity was confirmed in granulosa and cumulus cells via qPCR, immunohistochemistry, western blotting and desuccinylation activity. The presence of carbamoyl phosphate synthase I (CPS1), a target of SIRT5, was investigated by immunohistochemistry and follicular-fluid ammonium concentrations determined via microfluorometry. Women with reduced ovarian reserve or advanced maternal age had decreased SIRT5 mRNA, protein and desuccinylation activity in granulosa and cumulus cells resulting in an accumulation of follicular-fluid ammonium, presumably via alterations in activity of a SIRT5 target, CPS1, which was present in granulosa and cumulus cells. This suggests a role for SIRT5 in influencing oocyte quality and IVF outcomes.

The role of advanced maternal age and newborn sex in pregnancy outcome

2013 ◽  
Vol 3 (4) ◽  
pp. 159-164 ◽  
Author(s):  
Alessandro Favilli ◽  
Silvia Pericoli ◽  
Gian Carlo Di Renzo ◽  
Sandro Gerli
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
In Pregnancy

scholarly journals The Role of Oxytocin and the Effect of Stress During Childbirth: Neurobiological Basics and Implications for Mother and Child

2021 ◽  
Vol 12 ◽  
Author(s):  
Michael H. Walter ◽  
Harald Abele ◽  
Claudia F. Plappert
Keyword(s):  
Animal Studies ◽  
Infant Health ◽  
Negative Effects ◽  
Positive Effects ◽  
Current State ◽  
Maternal And Infant Health ◽  
Maternal Brain ◽  
Mother And Child ◽  
Controlling Processes

The neuropeptide oxytocin acts as a hormone and a neuromodulator, influencing a multitude of human social behaviors, including reproduction. During childbirth and the postpartum period, it plays a key role in regulating and controlling processes that ensure a safe birth and the health of mother and child. Especially the onset of labor, the progress of labor and initial breastfeeding are mediated by oxytocin. In the maternal brain it controls the initiation of the mother–infant bond and the mother’s emotional responses towards her child. In this review we summarize the current state of knowledge about the role of oxytocin during the different aspects and mechanisms of human childbirth, combining research from human and animal studies. Physiological and psychological stress during childbirth and lactation can have negative effects on the progress of labor, breastfeeding and bonding. We discuss how maternity caregivers can support the positive effects of oxytocin and minimize the effects of stress. Furthermore, we highlight aspects of the basic neurobiological principles and connections where further research is needed to improve our understanding of the regulation and the effects of oxytocin to support maternal and infant health.

scholarly journals How Education can help Solve Huge Perinatal Problems in Africa

2013 ◽  
Vol 7 (3) ◽  
pp. 292-295
Author(s):  
José M Carrera
Keyword(s):  
Reproductive Health ◽  
Health Professionals ◽  
Obstet Gynecol ◽  
Infant Health ◽  
Technical Training ◽  
Perinatal Medicine ◽  
The Poor ◽  
The People ◽  
Maternal And Infant Health

ABSTRACT We begin this article stating the dramatic situation of perinatal medicine in Africa. Then we revise the problems derived from the poor education of the population regarding reproductive health, the limited number of maternal and infant health professionals and their lack of technical training. We especially focus on the problems of standardizing the use of ultrasound in obstetrics and perinatal medicine. Finally, we insist on the role of education for professionals and for the people in general, as a tool to improve perinatal results. How to cite this article Carrera JM. How Education can help Solve Huge Perinatal Problems in Africa. Donald School J Ultrasound Obstet Gynecol 2013;7(3):292-295.

scholarly journals SUNNY SIDE UP? THE ROLE OF VITAMIN D IN FOLLICULAR DEVELOPMENT IN WOMEN OF ADVANCED MATERNAL AGE UNDERGOING INTRAUTERINE INSEMINATION

2020 ◽  
Vol 114 (3) ◽  
pp. e451
Author(s):  
Christy Oso ◽  
Nepheli Raptis ◽  
Emma Radley ◽  
Hanna Mandell ◽  
Lauren Grimm ◽  
...  
Keyword(s):  
Vitamin D ◽  
Maternal Age ◽  
Intrauterine Insemination ◽  
Follicular Development ◽  
Advanced Maternal Age
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