Single and multiple prenatal glucocorticoid exposures improve preterm newborn lamb cardiovascular and renal function similarly

2003 ◽  
Vol 188 (2) ◽  
pp. 444-453 ◽  
Author(s):  
Lynne M. Smith ◽  
M.Gore Ervin ◽  
Norihisa Wada ◽  
Machiko Ikegami ◽  
Alan H. Jobe
Keyword(s):  
Renal Function ◽  
Preterm Newborn ◽  
Newborn Lamb

scholarly journals 64 Drugs, Therapeutic Interventions, Diseases and Renal Function in Preterm Newborn Infants. A Multicenter Study

2005 ◽  
Vol 58 (2) ◽  
pp. 365-365
Author(s):  
L Cataldi ◽  
V Fanos ◽  
D Benini ◽  
F Riccobene ◽  
B De Mitri ◽  
...  
Keyword(s):  
Renal Function ◽  
Multicenter Study ◽  
Newborn Infants ◽  
Therapeutic Interventions ◽  
Preterm Newborn

Indomethacin and patent ductus arteriosus: effects on renal function in preterm lambs

1988 ◽  
Vol 254 (1) ◽  
pp. F38-F44
Author(s):  
C. A. Gleason ◽  
R. I. Clyman ◽  
M. A. Heymann ◽  
F. Mauray ◽  
R. Leake ◽  
...  
Keyword(s):  
Renal Function ◽  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Urine Volume ◽  
Preterm Newborn ◽  
Apparent Lack ◽  
Group 3 ◽  
Group 2 ◽  
Patent Ductus ◽  
Indomethacin Treatment

To examine the independent effects of a patent ductus arteriosus and of indomethacin therapy on the renal function of the preterm newborn, we created a preterm lamb model in which ductus diameter could be regulated. We studied 24 preterm newborn lambs. Eight lambs (group 1) had their ductus closed at delivery and received no indomethacin. Eight lambs (group 2) had their ductus closed and then received indomethacin (0.3 mg/kg) at 5.5 h; eight lambs (group 3) had their ductus kept open and then received indomethacin at 5.5 h. Hemodynamic and renal function measurements were made at 5 h (pretreatment) and at 12.5 h. In group 2 lambs there was a significant reduction in inulin clearance (GFR) and osmolal clearance after indomethacin. In contrast, lambs with an open ductus (group 3), when compared with lambs with a closed ductus (groups 1 and 2) at 5 h, already had significantly decreased blood pressure, GFR, urine volume, and osmolal clearance. Following indomethacin treatment, group 3 lambs showed no further decrease in renal function. We suggest that in preterm lambs with patent ductus, the apparent lack of renal dysfunction following indomethacin treatment reflects underlying diminished renal function.

Aquaporin-2 Excretion and Renal Function during the 1st Week of Life in Preterm Newborn Infants

2006 ◽  
Vol 104 (4) ◽  
pp. p121-p125 ◽  
Author(s):  
S. Iacobelli ◽  
F. Addabbo ◽  
F. Bonsante ◽  
G. Procino ◽  
G. Tamma ◽  
...  
Keyword(s):  
Renal Function ◽  
Newborn Infants ◽  
Preterm Newborn ◽  
Aquaporin 2

scholarly journals Changes in Renal Function and Blood Volume in the Newborn Lamb Delivered by Cesarean Section

1994 ◽  
Vol 36 (4) ◽  
pp. 506-513 ◽  
Author(s):  
Karen J Gibson ◽  
Eugenie R Lumbers
Keyword(s):  
Renal Function ◽  
Cesarean Section ◽  
Blood Volume ◽  
Newborn Lamb

scholarly journals Short-term Antenatal Glucocorticoid Exposure Alters Preterm Newborn Lamb Renal Responses to Intravascular Volume Expansion. • 823

1997 ◽  
Vol 41 ◽  
pp. 140-140
Author(s):  
Lynne M. Berry ◽  
Gore Ervin ◽  
Celso Rebello ◽  
Norihisa Wada ◽  
Machiko Ikegami ◽  
...  
Keyword(s):  
Volume Expansion ◽  
Preterm Newborn ◽  
Intravascular Volume ◽  
Short Term ◽  
Newborn Lamb ◽  
Renal Responses

The cardiovascular effects of isoproterenol in the preterm newborn lamb

1984 ◽  
Vol 12 (1) ◽  
pp. 33-35 ◽  
Author(s):  
ROBERT K. CRONE
Keyword(s):  
Cardiovascular Effects ◽  
Preterm Newborn ◽  
Newborn Lamb

scholarly journals Repetitive Antenatal Glucocorticoid Exposure Matures Preterm Newborn Lamb Renal Responses to Phenylephrine-induced Increases in Blood Pressure 250

1998 ◽  
Vol 43 ◽  
pp. 45-45
Author(s):  
Lynne M Berry ◽  
Norihisa Wada ◽  
M Gore Ervin ◽  
Machiko Ikegami ◽  
Alan H Jobe
Keyword(s):  
Blood Pressure ◽  
Preterm Newborn ◽  
Newborn Lamb ◽  
Renal Responses

scholarly journals Lung ultrasound accurately detects pneumothorax in a preterm newborn lamb model

2016 ◽  
Vol 52 (6) ◽  
pp. 643-648 ◽  
Author(s):  
Douglas A Blank ◽  
Stuart B Hooper ◽  
Corinna Binder-Heschl ◽  
Martin Kluckow ◽  
Andrew W Gill ◽  
...  
Keyword(s):  
Lung Ultrasound ◽  
Preterm Newborn ◽  
Newborn Lamb

Antenatal glucocorticoids alter premature newborn lamb neuroendocrine and endocrine responses to hypoxia

2000 ◽  
Vol 279 (3) ◽  
pp. R830-R838 ◽  
Author(s):  
M. Gore Ervin ◽  
James F. Padbury ◽  
Daniel H. Polk ◽  
Machiko Ikegami ◽  
Lynne M. Berry ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Plasma Cortisol ◽  
Left Ventricular ◽  
Preterm Newborn ◽  
Ang Ii ◽  
Ventricular Contractility ◽  
Adaptive Responses ◽  
Newborn Lamb ◽  
The Face ◽  
Postnatal Adaptation

Glucocorticoids are administered for preterm labor to improve postnatal adaptation. We assessed the effect of antenatal betamethasone (Beta) treatment on preterm newborn lamb neuroendocrine [catecholamine, arginine vasopressin (AVP)] and endocrine [triiodothyronine (T3), ANG II, and atrial natriuretic factor (ANF)] adaptive responses following delivery and a hypoxic challenge. Beta treatment included direct fetal injection at 0.2 (F0.2; n = 8) or 0.5 (F0.5; n = 7) mg/kg estimated fetal body weight or maternal injection with 0.2 ( n = 8) or 0.5 mg/kg (M0.5; n = 8). Control animals received fetal and maternal intramuscular injections of saline ( n = 8). After 24 h, lambs were delivered by cesarean section, surfactant treated, and ventilated for 4 h. Relative to the control lambs, 3 h after delivery, there was a marked suppression of plasma cortisol, epinephrine, norepinephrine, and ANG II levels and elevated plasma T3 and ANF levels, systolic blood pressure, and left ventricular contractility (dP/d t; F0.5 and M0.5) values in F0.5 and both maternal Beta-treated groups. However, Beta treatment augmented the cardiac output, cortisol, norepinephrine, AVP, and ANF responses to 20 min of hypoxia (Po 2 = 25–30 mmHg). We concluded that short-term (24 h) antenatal glucocorticoid exposure 1) alters preterm newborn postnatal blood pressure regulation in the face of marked depression of plasma cortisol, catecholamine, and ANG II levels and 2) augments the postnatal neuroendocrine and endocrine responses to a hypoxic challenge.

1248: Impact of Surgical Treatment of Renal Carcinoma on Renal Function and Blood Pressure: A Race- and Age-Dependent Association

2007 ◽  
Vol 177 (4S) ◽  
pp. 411-412
Author(s):  
Javier Miller ◽  
Angela Smith ◽  
Kris Gunn ◽  
Erik Kouba ◽  
Eric M. Wallen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Surgical Treatment ◽  
Renal Carcinoma ◽  
Age Dependent
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