Effects of combined Actinobacillus pleuropneumoniae challenge and change in environmental temperature on production, plasma insulin-like growth factor I (IGF-I), and cortisol parameters in growing pigs

2003 ◽  
Vol 54 (10) ◽  
pp. 1057 ◽  
Author(s):  
C. A. Kerr ◽  
G. J. Eamens ◽  
J. Briegel ◽  
P. A. Sheehy ◽  
L. R. Giles ◽  
...  
Keyword(s):  
Growth Factor ◽  
Temperature Stress ◽  
Feed Intake ◽  
Plasma Insulin ◽  
Environmental Temperature ◽  
Actinobacillus Pleuropneumoniae ◽  
Growing Pigs ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I

There is limited information on the combined effects of stress factors on physiological and endocrinological parameters in growing pigs. This study measured the effects of pleuropneumonia and changes in environmental temperature singularly and in combination. Forty entire male pigs (liveweight 33 ± 5 kg) were allocated to 1 of 4 treatments: control (22�C room temperature), Actinobacillus pleuropneumoniae challenge (Day�1), temperature stress (15�C for 8 h on Days 0, 1, and 2, and 30�C for 24 h on Day 6), or combined A.�pleuropneumoniae challenge and temperature stress. Control pigs had an average daily gain of 1.15 ± 0.12 kg/day and an average daily feed intake of 2.29 ± 0.06 kg/day over 8 days. Challenge with A. pleuropneumoniae caused a reduction (P < 0.001) in feed intake, weight gain, and plasma insulin-like growth factor I (IGF-I) concentration and an increase (P < 0.001) in plasma cortisol concentration. There was no significant effect of the temperature stress on circulating cortisol and IGF-I concentrations or liveweight gain. Thus, the treatment effects did not appear to be additive and the effects of the A. pleuropneumoniae challenge were more profound than changes in ambient air temperature.

scholarly journals Origin of Plasma Insulin-Like Growth Factor-I (IGF-I) During Estrus in Goats

2003 ◽  
Vol 49 (3) ◽  
pp. 253-258 ◽  
Author(s):  
Sumie NONAKA ◽  
Tsutomu HASHIZUME ◽  
Mami HORIUCHI ◽  
Utako MIKAMI ◽  
Takeshi OSAWA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasma Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Growth hormone increases insulin-like growth factor-I (IGF-I) and decreases IGF-II in plasma of growing pigs

1990 ◽  
Vol 124 (2) ◽  
pp. 269-275 ◽  
Author(s):  
P. C. Owens ◽  
R. J. Johnson ◽  
R. G. Campbell ◽  
F. J. Ballard
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Growing Pigs ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Igf Binding ◽  
Growth Factor I ◽  
Igf Binding Protein ◽  
Expected Increase

ABSTRACT Insulin-like growth factor-I (IGF-I) and IGF-II have been measured in plasma obtained from male and female pigs of two strains during daily administration of pituitary-derived porcine GH (pGH; 100 μg/kg) from 60 to 90 kg body weight. Each plasma sample was first chromatographed to separate the IGF from binding proteins in order to obtain reliable measurements. IGF-I concentrations showed no differences between strains, but were higher in untreated males (497 ± 43 (s.e.m.) μg/l) than females (299±15 μg/l). GH-treated animals had two-fold higher concentrations of IGF-I. IGF-II concentrations were not significantly different between sexes or strains, but were decreased in pigs treated with pGH (299 ± 28 μg/l) compared with controls (431 ± 32 μg/l). Binding protein concentrations, measured as interference in the IGF-I and IGF-II assays, were not different between sexes or strains, but were increased in pGH-treated animals. Taken together, these results indicate that in addition to the expected increase in IGF-I concentrations, exogenous administration of pGH to pigs leads to an increase in IGF-binding protein and a depression in IGF-II concentrations. Journal of Endocrinology (1990) 124, 269–275

Insulin-like growth factor I inhibits degradation and improves retention of protein in hindlimb muscle of lambs

1996 ◽  
Vol 271 (6) ◽  
pp. E973-E982 ◽  
Author(s):  
V. H. Oddy ◽  
P. C. Owens
Keyword(s):  
Growth Factor ◽  
Glucose Uptake ◽  
Femoral Artery ◽  
Feed Intake ◽  
Femoral Vein ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Hindlimb Muscle ◽  
Left Femoral Artery ◽  
Igf I

We infused recombinant human insulin-like growth factor I (IGF-I) for 4 h at 12.3 micrograms.h-1.kg live weight-1 directly into the left femoral artery and measured the rates of synthesis, degradation, and gain of protein by the treated and contralateral limbs of well-fed (n = 8), feed-restricted (n = 10), and fasted (n = 9) castrated male lambs. Reducing feed intake decreased net protein gain of hindlimb muscle, reduced hindlimb glucose uptake, and lowered arterial plasma concentrations of IGF-I, insulin, glucose, phenylalanine, tyrosine, and isoleucine. The effect of nutrition on IGF-binding proteins (IGFBP) was generally small; IGFBP-2 was more abundant in fasted lambs. Infusion of IGF-I into the left femoral artery increased plasma levels of IGF-I 2- to 4-fold in the left femoral vein and by 1.5- to 3-fold in the artery and right femoral vein. In the treated limb, IGF-I reduced protein degradation, increased protein gain, and increased glucose uptake without altering blood flow or oxygen uptake, regardless of feed intake. Systemically, IGF-I reduced plasma insulin, phenylalanine, tyrosine, isoleucine, and leucine in all nutrition groups. Plasma IGFBP-3 was increased by 4 h of IGF-I treatment in fasted but not in fed lambs. In fed but not fasted lambs, IGF-I increased blood glucose concentration. Effects of IGF-I on protein metabolism in the contralateral limb were affected by nutrition, generally more so in fasted than in unrestricted fed lambs.

Feed restriction in young bulls alters the onset of puberty in relationship with plasma insulin-like growth factor-I (IGF-I) and IGF-binding proteins☆

2000 ◽  
Vol 18 (2) ◽  
pp. 165-176 ◽  
Author(s):  
R Renaville ◽  
C Van Eenaeme ◽  
B.H Breier ◽  
L Vleurick ◽  
C Bertozzi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasma Insulin ◽  
Binding Proteins ◽  
Feed Restriction ◽  
Insulin Like Growth Factor ◽  
Igf Binding Proteins ◽  
Factor I ◽  
Igf I ◽  
Igf Binding ◽  
Growth Factor I

Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs

1988 ◽  
Vol 118 (1) ◽  
pp. 105-108 ◽  
Author(s):  
J. Eugen Eigenmann ◽  
Adel Amador ◽  
Donald F. Patterson
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Growth Factor ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
The Mean ◽  
Growth Factor I

Abstract. Plasma insulin-like growth factor I concentrations from proportionate, chondrodystrophic and giant breeds were evaluated and compared with body size. IGF-I plasma concentrations were 91.2 ± 10.9 μg/l in Keeshounds (proportionate dog), 122.6 ± 25.4 μg/l in Bassethounds (chondrodystrophic dog) and 280 ± 22.8 μg/l in German Shepherds (proportionate dog). The highest IGF-I level (389.6 ± 24.2 μg/l) was found in the New Foundland, a giant breed (mean ± sem). The mean body weight was 11.8 ±0.4 kg in Keeshounds, 15.4 ± 1.4 kg in Bassethounds, 32 ± 1.5 kg in German Shepherds, and 45.6 ± 1.7 kg in New Foundlands (mean ± sem). Body weight and plasma IGF-I concentration were significantly correlated (y (IGF-I) = −7.43 + 8.7 × (body weight); P < 0.0001.

scholarly journals Studies on the analysis of endocrinologic and metabolic factors controlling the concentration of plasma insulin-like growth factor-I (IGF-I) in maternal rats

1996 ◽  
Vol 72 (3) ◽  
pp. 573-586
Author(s):  
Hiroo SOHDA ◽  
Satoshi NAKAGO ◽  
Toru FUNAKOSHI ◽  
Matsuto MOCHIZUKI ◽  
Hajime MORIKAWA
Keyword(s):  
Growth Factor ◽  
Plasma Insulin ◽  
Insulin Like Growth Factor ◽  
Metabolic Factors ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I
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