Synthesis, Characterization, and DNA Binding Studies of Ruthenium(II) Complexes with 2-Pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione

2008 ◽  
Vol 61 (9) ◽  
pp. 732 ◽  
Author(s):  
Yi-Xian Yuan ◽  
Yi-Can Wang ◽  
Long Jiang ◽  
Feng Gao ◽  
Si-Min Liang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Imidazole Ring ◽  
Spectroscopic Properties ◽  
Spectroscopic Studies ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Base Pairs ◽  
Ancillary Ligands ◽  
Dna Base ◽  
Dna Binding Studies

Three novel asymmetric ruthenium(ii) complexes, [Ru(bpy)2(PAIDH)]2+ 1, [Ru(phen)2(PAIDH)]2+ 2, and [Ru(dmp)2(PAIDH)]2+ 3 (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline, PAIDH = 2-pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione), have been synthesized and characterized. The structure of the deprotonated complex [Ru(dmp)2(PAID)]+ 4 has been determined by single-crystal X-ray diffraction techniques, and the anthraquinone moiety is approximately coplanar with the imidazole ring. The DNA binding properities of complexes 1, 2, and 3 to calf-thymus DNA (CT-DNA) were investigated. Spectroscopic studies and viscosity experiments suggest that the RuII complexes intercalate into DNA base pairs by the extended anthraquinone unit, and the ancillary ligands have significant effects on the spectroscopic properties and DNA binding behaviour of the RuII complexes.

IN VITRO DNA BINDING STUDIES OF SELECTED HETEROCYCLIC COMPOUNDS

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (12) ◽  
pp. 24-26
Author(s):  
C Akhila ◽  
◽  
P Lalitha
Keyword(s):  
Dna Binding ◽  
Heterocyclic Compounds ◽  
Uv Spectroscopy ◽  
Binding Mode ◽  
Spectroscopic Technique ◽  
Binding Studies ◽  
Base Pairs ◽  
Dna Base ◽  
Dna Binding Studies

DNA binding studies of selected heterocyclic compounds belonging to the class of quinolinones, substituted quinolinones and thiones were carried out using ct-DNA. The binding nature of the compounds with DNA analyzed using UV-spectroscopy revealed the compounds to be DNA intercalators demonstrating the binding nature of compounds with DNA base pairs. This study is aimed at establishing a facile UV spectroscopic technique to arrive at the binding mode of DNA to ligands.

Synthesis, Chemical Characterisation, and DNA Binding Studies of Ferrocene-Incorporated Selenoureas

2013 ◽  
Vol 66 (6) ◽  
pp. 626 ◽  
Author(s):  
Raja Azadar Hussain ◽  
Amin Badshah ◽  
Muhammad Nawaz Tahir ◽  
Bhajan Lal ◽  
Inayat Ali Khan
Keyword(s):  
Cyclic Voltammetry ◽  
Dna Binding ◽  
Atomic Absorption Spectrophotometry ◽  
Free Drug ◽  
X Ray Diffraction ◽  
Peak Potential ◽  
Binding Studies ◽  
Vis Spectroscopy ◽  
Dna Binding Studies ◽  
And Diffusion

In this article we have presented the synthesis, chemical characterisation (by NMR and FTIR spectroscopy, atomic absorption spectrophotometry, elemental analysis, and single crystal X-ray diffraction), electrochemistry, and DNA binding studies (with cyclic voltammetry, viscometry, and UV-vis spectroscopy) of six new ferrocene incorporated selenoureas. All the six compounds interact electrostatically with DNA which was evident by a negative shift in the cyclic voltammetry peak potential of the drug–DNA adduct relative to the free drug. The drug–DNA binding constant was calculated by a decrease in peak current after the addition of DNA to the free drug. We have also reported binding site sizes and diffusion coefficients of the synthesised compounds.

Synthesis, Crystal Structure, and DNA-Binding Studies of a Ni(II) Complex with the Tris(N-methylbenzimidazol-2-ylmethyl)amine Ligand

2010 ◽  
Vol 65 (11) ◽  
pp. 1341-1348 ◽  
Author(s):  
Huilu Wu ◽  
Ke Li ◽  
Tao Sun ◽  
Bin Liu ◽  
Fei Jia ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Distorted Octahedral Geometry ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Binding Properties ◽  
Distorted Octahedral ◽  
Elemental Analyses ◽  
Dna Binding Studies ◽  
Dna Binding Properties

A tripod ligand tris(N-methylbenzimidazol-2-ylmethyl)amine (Mentb) and its nickel(II) picrate (pic) complex, with composition [Ni(Mentb)(DMF)(H2O)](pic)2, have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and UV/Vis measurements. Single-crystal X-ray diffraction revealed that the Ni atom is six-coordinated in a distorted octahedral geometry. In addition, the DNA-binding properties of the ligand Mentb and its Ni(II) complex have been investigated by electronic absorption, fluorescence and viscosity measurements. The experimental results suggest that the ligand and its Ni(II) complex bind to DNA via an intercalation binding mode, and their binding affinity to DNA follows the order of complex>ligand.

Thermal properties and DNA-binding studies of a new kind of acyl hydrazone compounds containing imidazole ring

2014 ◽  
Vol 582 ◽  
pp. 17-24 ◽  
Author(s):  
Jingwen Ren ◽  
Xiangrong Liu ◽  
Zaiwen Yang ◽  
Shunsheng Zhao
Keyword(s):  
Thermal Properties ◽  
Dna Binding ◽  
Imidazole Ring ◽  
Binding Studies ◽  
Acyl Hydrazone ◽  
Dna Binding Studies

The Dichloroplatinum(II) Complex of 5,5,7-Trimethyl-1,4-diazacycloheptane: Preparation, Crystal Structure and Binding to Nucleotides and DNA

1998 ◽  
Vol 51 (11) ◽  
pp. 977 ◽  
Author(s):  
Chih-Lynne Teo ◽  
Ronald R. Fenton ◽  
Peter Turner ◽  
Trevor W. Hambley
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Molecular Mechanics ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Triclinic Space Group ◽  
X Ray ◽  
Dna Binding Studies ◽  
Total Dna ◽  
R Value

The preparation of [Pt(tmdz)Cl2] (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) is described. The crystal structure has been determined by X-ray diffraction methods and refined to an R value of 0·048 (764F). The crystals are triclinic, space group P -1, a 8·023(2), b 10·874(4), c 14·207(3) Å, α 95·34(3), β 94·96(2), γ 94·97(3)°. N.m.r. studies and molecular mechanics methods show that only one diastereomer of the complex—that observed in the crystal structure—is energetically accessible. In total DNA binding studies, [Pt(tmdz)Cl2] binds less effectively and at a lower rate than cisplatin. The complex reacts with dG and d(GpG) to form a variety of isomeric products, as indicated by h.p.l.c. analysis.

Synthesis and spectroscopic studies on complexes of N,N’-bis-(2-pyridinecarboxaldimine)-1,8-diaminonaphthalene (L); DNA binding studies on Cu(II) complex

2009 ◽  
Vol 71 (5) ◽  
pp. 1851-1856 ◽  
Author(s):  
Mohammad Shakir ◽  
Mohammad Azam ◽  
Shama Parveen ◽  
Asad U. Khan ◽  
Farha Firdaus
Keyword(s):  
Dna Binding ◽  
Spectroscopic Studies ◽  
Binding Studies ◽  
Dna Binding Studies

Synthesis and DNA Binding Studies of Platinum (II) Complexes Based on Cyclodextrin

2013 ◽  
Vol 575-576 ◽  
pp. 280-286 ◽  
Author(s):  
Si Ping Tang ◽  
Yong Lan Feng ◽  
Zhi Feng Xu ◽  
De Ping Wang
Keyword(s):  
Dna Binding ◽  
Gel Electrophoresis ◽  
Platinum Complex ◽  
Spectroscopic Studies ◽  
Agarose Gel ◽  
Agarose Gel Electrophoresis ◽  
Binding Studies ◽  
Intercalative Mode ◽  
Dna Binding Studies ◽  
The Difference

Mono-modified β-cyclodextrins ligands, L1 (6-mono-(N-aminoethyl) amino-β-cyclodextrin) and L2 (6-mono-(N-(pyridin-2-yl) ethylamino)-β-cyclodextrin), and their platinum (II) complexes, 1 ([Pt (L1)Cl2]·8H2O) and 2 ([Pt (L2)Cl2]·4H2O), were successfully synthesized. As revealed by UV-Vis and CD spectroscopic studies, both complexes mainly adopt a non-intercalative mode with DNA. The interaction between platinum complex 1 and DNA was obviously observed in agarose Gel Electrophoresis. Meanwhile, two ligands L1, L2 and platinum complex 2 have no obvious interaction with DNA. The difference interaction between complexes 1, 2 and DNA should be ascribed to their different structures.

Synthesis, spectroscopic, powder X-ray diffraction and DNA binding studies on copper(II) complexes of 4,4′-diaminodiphenyl sulfone

2012 ◽  
Vol 9 (4) ◽  
pp. 441-448 ◽  
Author(s):  
L. Jaideva Singh ◽  
R. K. Hemakumar Singh ◽  
R. Chitra
Keyword(s):  
Dna Binding ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
X Ray ◽  
Diaminodiphenyl Sulfone ◽  
Dna Binding Studies
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