Synthesis, Chemical Characterisation, and DNA Binding Studies of Ferrocene-Incorporated Selenoureas

2013 ◽  
Vol 66 (6) ◽  
pp. 626 ◽  
Author(s):  
Raja Azadar Hussain ◽  
Amin Badshah ◽  
Muhammad Nawaz Tahir ◽  
Bhajan Lal ◽  
Inayat Ali Khan
Keyword(s):  
Cyclic Voltammetry ◽  
Dna Binding ◽  
Atomic Absorption Spectrophotometry ◽  
Free Drug ◽  
X Ray Diffraction ◽  
Peak Potential ◽  
Binding Studies ◽  
Vis Spectroscopy ◽  
Dna Binding Studies ◽  
And Diffusion

In this article we have presented the synthesis, chemical characterisation (by NMR and FTIR spectroscopy, atomic absorption spectrophotometry, elemental analysis, and single crystal X-ray diffraction), electrochemistry, and DNA binding studies (with cyclic voltammetry, viscometry, and UV-vis spectroscopy) of six new ferrocene incorporated selenoureas. All the six compounds interact electrostatically with DNA which was evident by a negative shift in the cyclic voltammetry peak potential of the drug–DNA adduct relative to the free drug. The drug–DNA binding constant was calculated by a decrease in peak current after the addition of DNA to the free drug. We have also reported binding site sizes and diffusion coefficients of the synthesised compounds.

Synthesis, Crystal Structure, and DNA-Binding Studies of a Ni(II) Complex with the Tris(N-methylbenzimidazol-2-ylmethyl)amine Ligand

2010 ◽  
Vol 65 (11) ◽  
pp. 1341-1348 ◽  
Author(s):  
Huilu Wu ◽  
Ke Li ◽  
Tao Sun ◽  
Bin Liu ◽  
Fei Jia ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Distorted Octahedral Geometry ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Binding Properties ◽  
Distorted Octahedral ◽  
Elemental Analyses ◽  
Dna Binding Studies ◽  
Dna Binding Properties

A tripod ligand tris(N-methylbenzimidazol-2-ylmethyl)amine (Mentb) and its nickel(II) picrate (pic) complex, with composition [Ni(Mentb)(DMF)(H2O)](pic)2, have been synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, and UV/Vis measurements. Single-crystal X-ray diffraction revealed that the Ni atom is six-coordinated in a distorted octahedral geometry. In addition, the DNA-binding properties of the ligand Mentb and its Ni(II) complex have been investigated by electronic absorption, fluorescence and viscosity measurements. The experimental results suggest that the ligand and its Ni(II) complex bind to DNA via an intercalation binding mode, and their binding affinity to DNA follows the order of complex>ligand.

The Dichloroplatinum(II) Complex of 5,5,7-Trimethyl-1,4-diazacycloheptane: Preparation, Crystal Structure and Binding to Nucleotides and DNA

1998 ◽  
Vol 51 (11) ◽  
pp. 977 ◽  
Author(s):  
Chih-Lynne Teo ◽  
Ronald R. Fenton ◽  
Peter Turner ◽  
Trevor W. Hambley
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Molecular Mechanics ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Triclinic Space Group ◽  
X Ray ◽  
Dna Binding Studies ◽  
Total Dna ◽  
R Value

The preparation of [Pt(tmdz)Cl2] (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) is described. The crystal structure has been determined by X-ray diffraction methods and refined to an R value of 0·048 (764F). The crystals are triclinic, space group P -1, a 8·023(2), b 10·874(4), c 14·207(3) Å, α 95·34(3), β 94·96(2), γ 94·97(3)°. N.m.r. studies and molecular mechanics methods show that only one diastereomer of the complex—that observed in the crystal structure—is energetically accessible. In total DNA binding studies, [Pt(tmdz)Cl2] binds less effectively and at a lower rate than cisplatin. The complex reacts with dG and d(GpG) to form a variety of isomeric products, as indicated by h.p.l.c. analysis.

Synthesis, spectroscopic, powder X-ray diffraction and DNA binding studies on copper(II) complexes of 4,4′-diaminodiphenyl sulfone

2012 ◽  
Vol 9 (4) ◽  
pp. 441-448 ◽  
Author(s):  
L. Jaideva Singh ◽  
R. K. Hemakumar Singh ◽  
R. Chitra
Keyword(s):  
Dna Binding ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
X Ray ◽  
Diaminodiphenyl Sulfone ◽  
Dna Binding Studies

Synthesis, Characterization, and DNA Binding Studies of Ruthenium(II) Complexes with 2-Pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione

2008 ◽  
Vol 61 (9) ◽  
pp. 732 ◽  
Author(s):  
Yi-Xian Yuan ◽  
Yi-Can Wang ◽  
Long Jiang ◽  
Feng Gao ◽  
Si-Min Liang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Imidazole Ring ◽  
Spectroscopic Properties ◽  
Spectroscopic Studies ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Base Pairs ◽  
Ancillary Ligands ◽  
Dna Base ◽  
Dna Binding Studies

Three novel asymmetric ruthenium(ii) complexes, [Ru(bpy)2(PAIDH)]2+ 1, [Ru(phen)2(PAIDH)]2+ 2, and [Ru(dmp)2(PAIDH)]2+ 3 (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline, PAIDH = 2-pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione), have been synthesized and characterized. The structure of the deprotonated complex [Ru(dmp)2(PAID)]+ 4 has been determined by single-crystal X-ray diffraction techniques, and the anthraquinone moiety is approximately coplanar with the imidazole ring. The DNA binding properities of complexes 1, 2, and 3 to calf-thymus DNA (CT-DNA) were investigated. Spectroscopic studies and viscosity experiments suggest that the RuII complexes intercalate into DNA base pairs by the extended anthraquinone unit, and the ancillary ligands have significant effects on the spectroscopic properties and DNA binding behaviour of the RuII complexes.

Characterization and DNA binding studies of unexplored imidazolidines by electronic absorption spectroscopy and cyclic voltammetry

2013 ◽  
Vol 120 ◽  
pp. 90-97 ◽  
Author(s):  
Afzal Shah ◽  
Erum Nosheen ◽  
Shamsa Munir ◽  
Amin Badshah ◽  
Rumana Qureshi ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Dna Binding ◽  
Absorption Spectroscopy ◽  
Electronic Absorption ◽  
Electronic Absorption Spectroscopy ◽  
Binding Studies ◽  
Dna Binding Studies

Towards understanding the mechanism of action of mithramycin and its analogues: dimerization and DNA binding studies

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
S Weidenbach ◽  
C Hou ◽  
JM Chen ◽  
OV Tsodikov ◽  
J Rohr
Keyword(s):  
Dna Binding ◽  
Mechanism Of Action ◽  
Binding Studies ◽  
Dna Binding Studies

Metal Based Pharmacological Active Agents: Structural, Electrochemical, DNA Binding Studies and Antibacterial Properties

2015 ◽  
Vol 9 (4) ◽  
pp. 210-218 ◽  
Author(s):  
Harun Muslu ◽  
Derya Kılıcaslan ◽  
Mustafa Cesme ◽  
Aysegul Golcu ◽  
Sibel Ozkan
Keyword(s):  
Dna Binding ◽  
Antibacterial Properties ◽  
Binding Studies ◽  
Dna Binding Studies

BSA and DNA Binding Studies of Aspergillus foetidus Mediated Biosynthesized CdS Nanoparticles

2016 ◽  
Vol 12 (6) ◽  
pp. 781-788 ◽  
Author(s):  
Tina Nasrin ◽  
Ratan Sadhukhan ◽  
Tapan Kumar Das
Keyword(s):  
Dna Binding ◽  
Cds Nanoparticles ◽  
Binding Studies ◽  
Aspergillus Foetidus ◽  
Dna Binding Studies

Arene ruthenium, rhodium and iridium complexes containing benzamide derivative ligands: Study of interesting bonding modes, antibacterial, antioxidant and DNA binding studies

2021 ◽  
Vol 937 ◽  
pp. 121731
Author(s):  
Lathewdeipor Shadap ◽  
Nipanshu Agarwal ◽  
Vivek Chetry ◽  
Krishna Mohan Poluri ◽  
Werner Kaminsky ◽  
...  
Keyword(s):  
Dna Binding ◽  
Iridium Complexes ◽  
Binding Studies ◽  
Dna Binding Studies

DNA-binding studies and antioxidant activities of two-, three- and four-coordinate silver(i) complexes containing bis(2-benzimidazolyl)aniline derivatives

2014 ◽  
Vol 38 (8) ◽  
pp. 3688-3698 ◽  
Author(s):  
Huilu Wu ◽  
Yanhui Zhang ◽  
Chengyong Chen ◽  
Jiawen Zhang ◽  
Yuchen Bai ◽  
...  
Keyword(s):  
Dna Binding ◽  
Hydroxyl Radical ◽  
Superoxide Radical ◽  
Antioxidant Activities ◽  
Binding Studies ◽  
Aniline Derivatives ◽  
Novel Structure ◽  
Dna Binding Studies

Three novel structure Ag(i) complexes have been synthesized and characterized. The three ligands and Ag(i) complexes bind to DNA in an intercalation mode. The Ag(i) complexes have stronger ability of antioxidation for hydroxyl radical and superoxide radical.

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