Synthesis and X-Ray Crystal Structure of Cynandione B Analogues
The synthesis of analogues of cynandione B, a phenolic acetophenone from Cynanchum taiwanianum, is described. The one-step conversion of benzochromenones to the heptacyclic spiroacetal core of cynandione B using methylmagnesium bromide is investigated and structural requirements for this novel transformation established. X-ray crystal structure analysis has established the relative configuration in these unusual heterocycles.