4-Aminochroman-3-ols-Cyclic Analogues of 1-Amino-3-aryloxypropan-2-ols, the Potent β-Adrenergic Blocking Agents

1979 ◽  
Vol 32 (3) ◽  
pp. 619 ◽  
Author(s):  
BV Lap ◽  
LR Williams ◽  
CH Lim ◽  
AJ Jones
Keyword(s):  
Iterative Refinement ◽  
Trans Isomers ◽  
Blocking Agents ◽  
Cis And Trans Isomers ◽  
Stereospecific Reactions ◽  
Cis And Trans ◽  
Adrenergic Blocking ◽  
Adrenergic Blocking Agents

cis- and trans-4-Aminochroman-3-ols have been prepared and their configurations have been established by stereospecific reactions. The configurations of the cis and trans isomers of both 4-amino-chroman-3-ols and 3-aminochroman-4-ols were confirmed by analysis and iterative refinement of the 270-MHz proton N.M.R. spectra.

Cyclic analogues of β-adrenergic blocking agents cis- and trans-3-Amino-6-bromochroman-4-ols

1976 ◽  
Vol 29 (8) ◽  
pp. 1791 ◽  
Author(s):  
BV Lap ◽  
LR Williams
Keyword(s):  
Sodium Borohydride ◽  
Coupling Constants ◽  
Blocking Agents ◽  
Rate Of Hydrolysis ◽  
Cis And Trans ◽  
Adrenergic Blocking ◽  
Hydrolysis Of ◽  
Adrenergic Blocking Agents

N-(6-Bromo-4-oxochroman-3-yl)acetamide (4; R = Ac) can be reduced by sodium borohydride to the cis-N-(6-bromo-4-hydroxychroman-3-yl)acetamide (6) and this can be hydrolysed to give the cis-3-amino-6-bromochroman-4-ol (7) or converted into the corresponding trans-3-amino-6-bromo- chroman-4-ol (12) by chlorination with inversion followed by hydrolysis of the chloride (8) to the alcohol with retention of configuration. The assignment of configuration of the 3,4-substituted chromans is based on the value of the coupling constants between the H3 proton and the methylene protons on C2 and is supported by an observed difference in the rate of hydrolysis of the two N-(6-bromo-4-chlorochroman-3-yl)acetamides.

ChemInform Abstract: CYCLIC ANALOGUES OF β-ADRENERGIC BLOCKING AGENTS CIS- AND TRANS-3-AMINO-6-BROMOCHROMAN-4-OLS

1976 ◽  
Vol 7 (51) ◽  
pp. no-no
Author(s):  
BUI VINH LAP BUI VINH LAP ◽  
L. R. WILLIAMS
Keyword(s):  
Blocking Agents ◽  
Cis And Trans ◽  
Adrenergic Blocking ◽  
Adrenergic Blocking Agents

scholarly journals The Metabolism of 14C-Labeled cis and trans Isomers of Octadecenoic and Octadecadienoic Acids

1964 ◽  
Vol 239 (8) ◽  
pp. 2482-2488
Author(s):  
Katsuto Ono ◽  
Donald S. Fredrickson
Keyword(s):  
Trans Isomers ◽  
Cis And Trans Isomers ◽  
Cis And Trans ◽  
Octadecadienoic Acids

Cis and trans isomers of 1-(5-bromothiophen-2-yl)-3-(10-chloroanthracen-9-yl)prop-2-en-1-one: Synthesis and characterization

2021 ◽  
Vol 1236 ◽  
pp. 130228
Author(s):  
P. Naresh ◽  
B. Pramodh ◽  
S. Naveen ◽  
S. Ganguly ◽  
J. Panda ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Trans Isomers ◽  
Cis And Trans Isomers ◽  
Cis And Trans

scholarly journals Identification of Anthocyanin Compounds in Butterfly Pea Flowers (Clitoria ternatea L.) by Ultra Performance Liquid Chromatography/Ultraviolet Coupled to Mass Spectrometry

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4539
Author(s):  
Nguyen Minh Thuy ◽  
Vo Minh ◽  
Tran Ben ◽  
My Tuyen Thi Nguyen ◽  
Ho Ha ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Ultra Performance Liquid Chromatography ◽  
Negative Ion ◽  
Trans Isomers ◽  
Clitoria Ternatea ◽  
Flower Extract ◽  
Cis And Trans Isomers ◽  
Butterfly Pea ◽  
Cis And Trans

Butterfly pea flower have great sensory attraction, but they have not yet been used widely in Vietnam. Extracts of butterfly pea flowers can be used conveniently as a natural blue colorant for food products. In this study, the identification of anthocyanin compounds in butterfly pea flowers was performed by UPLC coupled with a UV and Mass spectrometer instrument. Positive and negative ion electrospray MS/MS chromatograms and spectra of the anthocyanin compounds were determined. By analyzing the chromatograms and spectra for each ion, five anthocyanins were identified in the butterfly pea flower extract; these were delphinidin-3-(6”‐p-coumaroyl)-rutinoside, cyanidin 3-(6”-p-coumaroyl)-rutinoside, delphinidin-3-(p-coumaroyl) glucose in both cis- and trans- isomers, cyanidin-3-(p-coumaroyl-glucoside) and delphinidin-3-pyranoside. Additionally, based on their intensity, it was determined that cyanidin-3-(p-coumaroyl-glucoside) was the most abundant anthocyanin, followed by cyanidin 3-(6”-p-coumaroyl)-rutinoside, delphinidin-3-(p-coumaroyl-glucoside), delphinidin-3-(6”-p-coumaroyl)-rutinoside and delphinidin-3-pyranoside. In this study, cyanidin derivatives were discovered in butterfly pea flower extract, where these compounds had not been detected in previous studies.

Unveiling the coexistence of cis- and trans-isomers in the hydrolysis of ZrO2: A coupled DFT and high-resolution photoelectron spectroscopy study

2020 ◽  
Vol 153 (24) ◽  
pp. 244308
Author(s):  
Ali Abou Taka ◽  
Mark C. Babin ◽  
Xianghai Sheng ◽  
Jessalyn A. DeVine ◽  
Daniel M. Neumark ◽  
...  
Keyword(s):  
High Resolution ◽  
Photoelectron Spectroscopy ◽  
Spectroscopy Study ◽  
Trans Isomers ◽  
Cis And Trans Isomers ◽  
Cis And Trans ◽  
Hydrolysis Of

Beta-adrenergic Blocking Agents and Dental Vasoconstrictors

2010 ◽  
Vol 54 (4) ◽  
pp. 687-696 ◽  
Author(s):  
Elliot V. Hersh ◽  
Helen Giannakopoulos
Keyword(s):  
Beta Adrenergic ◽  
Blocking Agents ◽  
Adrenergic Blocking ◽  
Beta Adrenergic Blocking Agents ◽  
Adrenergic Blocking Agents
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