Tea tree oil: a potential alternative for the management of methicillin-resistant Staphylococcus aureus (MRSA)

2005 ◽  
Vol 10 (1) ◽  
pp. 32-34 ◽  
Author(s):  
Christine F. Carson ◽  
Syndie Messager ◽  
Katherine A. Hammer ◽  
Thomas V. Riley
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Tea Tree Oil ◽  
Methicillin Resistant ◽  
Tea Tree ◽  
Potential Alternative

scholarly journals Iron Sequestrant DIBI, a Potential Alternative for Nares Decolonization of Methicillin-Resistant Staphylococcus aureus, Is Anti-infective and Inhibitory for Mupirocin-Resistant Isolates

2020 ◽  
Vol 64 (3) ◽  
Author(s):  
David S. Allan ◽  
Maria del Carmen Parquet ◽  
Kimberley A. Savage ◽  
Bruce E. Holbein
Keyword(s):  
Staphylococcus Aureus ◽  
Developmental Stage ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Opportunistic Infections ◽  
Major Health ◽  
Methicillin Resistant ◽  
Content Type ◽  
Health Burden ◽  
Potential Alternative ◽  
Infective Agent

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) opportunistic infections are a major health burden. Decolonization of hospitalized patients with mupirocin (MUP) has reduced the incidence of infection but has led to MUP resistance. DIBI is a developmental-stage anti-infective agent that sequesters bacterial iron and bolsters innate host iron-withdrawal defenses. Clinical isolates possessing low, high, or no MUP resistance all had similarly high susceptibilities to DIBI. Intranasal DIBI reduced nares bacterial burdens in mice to the same extent as MUP. No resistance was found after exposure to DIBI.

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