Leukaemia inhibitory factor increases αvβ3 integrin expression in cultured mouse blastocysts

2020 ◽  
pp. NULL
Author(s):  
Ali Hosseini ◽  
Nassim Ghorbanmehr ◽  
Mojtaba Rezazadeh Valojerdi ◽  
Mehrdad Bakhtiyari ◽  
Bahar Movaghar
Keyword(s):  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Αvβ3 Integrin ◽  
Integrin Expression

scholarly journals Absence of the αvβ3 Integrin Dictates the Time-Course of Angiogenesis in the Hypoxic Central Nervous System: Accelerated Endothelial Proliferation Correlates with Compensatory Increases in α5β1 Integrin Expression

2010 ◽  
Vol 30 (5) ◽  
pp. 1031-1043 ◽  
Author(s):  
Longxuan Li ◽  
Jennifer V Welser ◽  
Richard Milner
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Time Course ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Brain Endothelial Cells ◽  
Endothelial Proliferation ◽  
Β3 Integrin ◽  
Α5β1 Integrin

Cerebral angiogenesis is an important adaptive response to hypoxia. As the αvβ3 integrin is induced on angiogenic vessels in the ischemic central nervous system (CNS), and the suggested angiogenic role for this integrin in other systems, it is important to determine whether the αvβ3 integrin is an important mediator of cerebral angiogenesis. αvβ3 integrin expression was examined in a model of cerebral hypoxia, in which mice were subject to hypoxia (8% O2) for 0, 4, 7, or 14 days. Immunofluorescence and western blot analysis revealed that in the hypoxic CNS, αvβ3 integrin was strongly induced on angiogenic brain endothelial cells (BEC), along with its ligand vitronectin. In the hypoxia model, β3 integrin-null mice showed no obvious defect in cerebral angiogenesis. However, early in the angiogenic process, BEC in these mice showed an increased mitotic index that correlated closely with increased α5 integrin expression. In vitro experiments confirmed α5 integrin upregulation on β3 integrin-null BEC, which also correlated with increased BEC proliferation on fibronectin. These studies confirm hypoxic induction of αvβ3 integrin on angiogenic vessels, but suggest distinct roles for the BEC integrins αvβ3 and α5β1 in cerebral angiogenesis, with αvβ3 having a nonessential role, and α5β1 promoting BEC proliferation.

Elevated Leukaemia Inhibitory Factor (LIF) Expression in Lesional Psoriatic Skin: Correlation with Interleukin (IL)-8 Expression

2001 ◽  
Vol 28 (3) ◽  
pp. 115-122 ◽  
Author(s):  
Jacek Szepietowski ◽  
Craig Walker ◽  
John A.A. Hunter ◽  
Roderick C. McKenzie
Keyword(s):  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Psoriatic Skin ◽  
Lesional Psoriatic Skin

Up-regulation of leukaemia inhibitory factor and interleukin-6 in transected sciatic nerve and muscle following denervation

1996 ◽  
Vol 6 (2) ◽  
pp. 105-114 ◽  
Author(s):  
J.B. Kurek ◽  
L. Austin ◽  
S.S. Cheema ◽  
P.F. Bartlett ◽  
M. Murphy
Keyword(s):  
Sciatic Nerve ◽  
Interleukin 6 ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor

scholarly journals Leukaemia inhibitory factor enhances tissue factor expression in human monocyte-derived macrophages: a gp130-mediated mechanism

1999 ◽  
Vol 107 (4) ◽  
pp. 747-755 ◽  
Author(s):  
Simcha R. Meisel ◽  
Ilan Shimon ◽  
Thomas S. Edgington ◽  
Shlomo Melmed ◽  
Bojan Cercek ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Human Monocyte ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Tissue Factor Expression ◽  
Factor Expression

D-factor/leukaemia inhibitory factor: Evidence for its role as a mediator in acute and chronic inflammatory disease

Cytokine ◽  
1994 ◽  
Vol 6 (6) ◽  
pp. 589-596 ◽  
Author(s):  
H.Richard Alexander ◽  
Kevin G. Billingsley ◽  
Mark I. Block ◽  
Douglas L. Fraker
Keyword(s):  
Inflammatory Disease ◽  
Chronic Inflammatory Disease ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor

Nitric Oxide Induces Angiogenesis and Upregulates αvβ3 Integrin Expression on Endothelial Cells

2000 ◽  
Vol 60 (3) ◽  
pp. 269-280 ◽  
Author(s):  
Paul C. Lee ◽  
Melina R. Kibbe ◽  
Matthew J. Schuchert ◽  
Donna B. Stolz ◽  
Simon C. Watkins ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Αvβ3 Integrin ◽  
Integrin Expression

scholarly journals R-200. Endometrial interleukin-6 and leukaemia inhibitory factor—regulation by oestradiol, progesterone, and cytokines

1999 ◽  
Vol 14 (Suppl_3) ◽  
pp. 368-368
Author(s):  
T. Strowitzki ◽  
M. von Wolff ◽  
C.J. Thaler ◽  
S. Stieger ◽  
C. Zepf ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor
Sign in / Sign up

Export Citation Format

Share Document