scholarly journals Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

2009 ◽  
Vol 106 (9) ◽  
pp. 3390-3395 ◽  
Author(s):  
B. Kruger ◽  
S. Krick ◽  
N. Dhillon ◽  
S. M. Lerner ◽  
S. Ames ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Reperfusion Injury ◽  
Human Kidney ◽  
Ischemia And Reperfusion ◽  
Toll Like Receptor ◽  
Ischemia And Reperfusion Injury ◽  
Toll Like Receptor 4

scholarly journals Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

2020 ◽  
Vol 9 (1) ◽  
pp. 253 ◽  
Author(s):  
Gertrude J. Nieuwenhuijs-Moeke ◽  
Søren E. Pischke ◽  
Stefan P. Berger ◽  
Jan Stephan F. Sanders ◽  
Robert A. Pol ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Reperfusion Injury ◽  
Interstitial Fibrosis ◽  
Molecular Pathways ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Tubular Atrophy ◽  
Chronic Graft Dysfunction ◽  
Injury And Repair

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.

The Role of Toll-like Receptor (TLR) 2 and 9 in Renal Ischemia and Reperfusion Injury

Urology ◽  
2013 ◽  
Vol 81 (6) ◽  
pp. 1379.e15-1379.e20 ◽  
Author(s):  
Xingzhi Li ◽  
Zhizhong Yun ◽  
Zhaohui Tan ◽  
Sanxiang Li ◽  
Dong Wang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Renal Ischemia ◽  
Ischemia And Reperfusion ◽  
Toll Like Receptor ◽  
Ischemia And Reperfusion Injury
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