scholarly journals Estrogen receptor ESR1 controls cell migration by repressing chemokine receptor CXCR4 in the zebrafish posterior lateral line system

2010 ◽  
Vol 107 (14) ◽  
pp. 6358-6363 ◽  
Author(s):  
L. Gamba ◽  
N. Cubedo ◽  
A. Ghysen ◽  
G. Lutfalla ◽  
C. Dambly-Chaudiere
Keyword(s):  
Estrogen Receptor ◽  
Cell Migration ◽  
Lateral Line ◽  
Chemokine Receptor ◽  
Lateral Line System ◽  
Line System ◽  
Chemokine Receptor Cxcr4 ◽  
Posterior Lateral Line

scholarly journals Histone Demethylase PHF8 Is Required for the Development of the Zebrafish Inner Ear and Posterior Lateral Line

2020 ◽  
Vol 8 ◽  
Author(s):  
Jing He ◽  
Zhiwei Zheng ◽  
Xianyang Luo ◽  
Yongjun Hong ◽  
Wenling Su ◽  
...  
Keyword(s):  
Cell Migration ◽  
Inner Ear ◽  
Lateral Line ◽  
Target Genes ◽  
Histone Demethylase ◽  
Otic Vesicle ◽  
Lateral Line System ◽  
Potential Candidate ◽  
Line System ◽  
Posterior Lateral Line

Histone demethylase PHF8 is crucial for multiple developmental processes, and hence, the awareness of its function in developing auditory organs needs to be increased. Using in situ hybridization (ISH) labeling, the mRNA expression of PHF8 in the zebrafish lateral line system and otic vesicle was monitored. The knockdown of PHF8 by morpholino significantly disrupted the development of the posterior lateral line system, which impacted cell migration and decreased the number of lateral line neuromasts. The knockdown of PHF8 also resulted in severe malformation of the semicircular canal and otoliths in terms of size, quantity, and position during the inner ear development. The loss of function of PHF8 also induced a defective differentiation in sensory hair cells in both lateral line neuromasts and the inner ear. ISH analysis of embryos that lacked PHF8 showed alterations in the expression of many target genes of several signaling pathways concerning cell migration and deposition, including the Wnt and FGF pathways. In summary, the current findings established PHF8 as a novel epigenetic element in developing auditory organs, rendering it a potential candidate for hearing loss therapy.

scholarly journals Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Akihiro Urasaki ◽  
Seiya Morishita ◽  
Kosuke Naka ◽  
Minato Uozumi ◽  
Kouki Abe ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lateral Line ◽  
Lateral Line System ◽  
Collective Cell Migration ◽  
Line System ◽  
Posterior Lateral Line

scholarly journals Development of the posterior lateral line system in Thunnus thynnus, the atlantic blue-fin tuna, and in its close relative Sarda sarda

2010 ◽  
Vol 54 (8-9) ◽  
pp. 1317-1322 ◽  
Author(s):  
Alain Ghysen ◽  
Kevin Schuster ◽  
Denis Coves ◽  
Fernando de la Gandara ◽  
Nikos Papandroulakis ◽  
...  
Keyword(s):  
Lateral Line ◽  
Close Relative ◽  
Lateral Line System ◽  
Thunnus Thynnus ◽  
Line System ◽  
Posterior Lateral Line ◽  
Sarda Sarda

Electroreceptors and Direction Specific Arrangement in the Lateral Line System of Salamanders?

1981 ◽  
Vol 36 (5-6) ◽  
pp. 493-496 ◽  
Author(s):  
Bernd Fritzsch
Keyword(s):  
Lateral Line ◽  
Fiber Bundles ◽  
Sensory Cells ◽  
Lateral Line System ◽  
Line System ◽  
Lateral Line Organ ◽  
Posterior Lateral Line ◽  
Afferent Fibers ◽  
Lateral Line Afferents ◽  
Line Organ

Abstract The arrangement of the lateral line afferents of salamanders as revealed by transganglionic staining with horse­ radish peroxidase is described. Each lateral line organ is supplied by two fibers only. In the medulla these two afferent fibers run in separate fiber bundles. It is suggested, that only those fibers contacting lateral line sensory cells with the same polarity form together one bundle. Bundles formed by anterior or posterior lateral line afferents are also clearly separated. Beside the lateral line organs smaller pit organs are described. These organs are supplied by one afferent only which reveals an arrangement in the medulla different from that of the lateral line afferents. Based on anatomical facts, these small pit organs are considered to be electroreceptors. Centrifugally projecting neurons, most probably efferents, are described in the medulla.

scholarly journals Molecular basis of cell migration in the fish lateral line: Role of the chemokine receptor CXCR4 and of its ligand, SDF1

2002 ◽  
Vol 99 (25) ◽  
pp. 16297-16302 ◽  
Author(s):  
N. B. David ◽  
D. Sapede ◽  
L. Saint-Etienne ◽  
C. Thisse ◽  
B. Thisse ◽  
...  
Keyword(s):  
Cell Migration ◽  
Lateral Line ◽  
Chemokine Receptor ◽  
Molecular Basis ◽  
Chemokine Receptor Cxcr4

scholarly journals Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions

2021 ◽  
Vol 8 ◽  
Author(s):  
Ramona Dries ◽  
Annemarie Lange ◽  
Sebastian Heiny ◽  
Katja I. Berghaus ◽  
Martin Bastmeyer ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Lateral Line ◽  
System Development ◽  
Lateral Line System ◽  
Collective Cell Migration ◽  
Fgf Receptor ◽  
Line System ◽  
Posterior Lateral Line ◽  
Neural Cell Adhesion ◽  
Reduce Cell Proliferation

The posterior lateral line system (pLLS) of aquatic animals comprises small clustered mechanosensory organs along the side of the animal. They develop from proneuromasts, which are deposited from a migratory primordium on its way to the tip of the tail. We here show, that the Neural Cell Adhesion Molecule Ncam1b is an integral part of the pathways initiating and regulating the development of the pLLS in zebrafish. We find that morpholino-knockdowns of ncam1b (i) reduce cell proliferation within the primordium, (ii) reduce the expression of Fgf target gene erm, (iii) severely affect proneuromast formation, and (iv) affect primordium migration. Ncam1b directly interacts with Fgf receptor Fgfr1a, and a knockdown of fgfr1a causes similar phenotypic changes as observed in ncam1b-morphants. We conclude that Ncam1b is involved in activating proliferation by triggering the expression of erm. In addition, we demonstrate that Ncam1b is required for the expression of chemokine receptor Cxcr7b, which is crucial for directed primordial migration. Finally, we show that the knockdown of ncam1b destabilizes proneuromasts, suggesting a further function of Ncam1b in strengthening the cohesion of proneuromast cells.

scholarly journals Origin and Early Development of the Posterior Lateral Line System of Zebrafish

2010 ◽  
Vol 30 (24) ◽  
pp. 8234-8244 ◽  
Author(s):  
A. F. Sarrazin ◽  
V. A. Nunez ◽  
D. Sapede ◽  
V. Tassin ◽  
C. Dambly-Chaudiere ◽  
...  
Keyword(s):  
Early Development ◽  
Lateral Line ◽  
Lateral Line System ◽  
Line System ◽  
Posterior Lateral Line
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